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Finding Cures. Saving Children.
Bing Yan, PhD
Member, St. Jude Faculty
Director, High-Throughput Analytical Chemistry Facility
Departments
Chemical Biology & Therapeutics
Contact Information
Bing Yan, PhD
Chemical Biology & Therapeutics
MS 1000, Room E9064
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: bing.yan@stjude.org
Phone: (901) 595-2797
FAX: (901) 595-5715
Education
PhD – Columbia University, New York, New York (1990)
Postdoc – Cambridge University
Postdoc – University of Texas Medical School at Houston
Research Interests
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Develop nanoparticle library approach for cancer diagnostics and therapeutics research
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Discover small molecule anti-cancer agents
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Develop high-throughput analytical methods and approaches for drug discovery
Selected Publications
Milacic V, Jiao PF, Zhang B, Yan B*, Dou QP.* Novel 8-Hydroxylquinoline Analogs Induce Copper-Dependent Proteasome Inhibition and Cell Death in Human Breat Cancer Cells. International Journal of Oncology 2009 (in press).
Zhang B, Yan B.*Analytical Strategies for Characterizing Nanoparticle's Surface Chemistry. Analytical and Bioanalytical Chemistry. Web Publication Date: Aug 1, 2009.
Luo M*, Yan B.*A Simple Synthesis of Octaphenylcyclotetra(Siloxane). Tetrahedron Letters 50(37), 5208-5209, 2009.
Mu QX, Du GQ, Chen TS, Zhang B, Yan B.* Suppression of Human Bone Mophorgenetic Protein (BMP) Signaling by Carboxylated Single-Walled Carbon Nanotubes. ACS Nano 3(5), 1139-1144, 2009.
Zhang B, Xing YH, Zhou HY, Li ZW, Mu QX, Yan B.* Functionalized Carbon Nanotubes Specifically Bind to Chymotrypsin Catalytic Site and Regulate its Enzymatic Function. Nano Letters 9(6), 2280-2284, 2009.
Zhang Q, Feng W, Zhou HY, Yan B.* Advances in Preclinical Small Molecules for the Treatment of Non-Small Cell Lung Cancer. Expert Opinion on Therapeutic Patents 19(6), 731-751, 2009.
Qu G, Bai Y, Zhang Y, Jia Q, Zhang W, Yan B*. The effect of multiwalled carbon nanotube agglomeration on their accumulation in and damage to organs in mice. Carbon, 47, 2060-2069, 2009.
Mu Q, Li Z, Li X, Mishra SR, Zhang B, Si Z, Yang L, Jiang W, Yan B*. Characterization of Protein Clusters of Diverse Magnetic Nanoparticles and Their Dynamic Interactions with Human Cells. J Phys Chem C 113 (14), 5390–5395, 2009.
Ma XF, Shi RR, Zhang B, Yan B.* Kinetics of Resin-Supported Mitsunobu Esterification and Etherification Reactions. J Comb Chem 11 (3) 438-445, 2009.
Du FF, Zhou HY, Chen LX, Zhang B, Yan B.* Structure Elucidation of Nanoparticle-Bound Organic Molecules by 1H NMR. Trends in Anal Chem 28(1), 88-95, 2009.
Zhou HY, Du FF, Li X, Zhang B, Li W, Yan B.* Characterization of Organic Molecules Attached to Gold Nanoparticle Surface Using High Resolution Magic Angle Spinning 1H NMR. J Phys Chem C, 112 (49) 19360-19366, 2008.
Yu YM, Zhang Q, Mu QX, Zhang B, Yan B.* Exploring the Immunotoxicity of Carbon Nanotubes. Nanoscale Research Letters 3, 271-277, 2008.
Lemoff A, Yan B.* Dual Detection Approach to a More Accurate Measure of Relative Purity in High-Throughput Characterization of Compound Collections. J Comb Chem 10(5), 746-751, 2008.
Qi M, Zhou H, Ma X, Zhang B, Jefferies C, Yan B.* Feasibility of a Self-Calibrated LC/MS/UV Method to Determine the Absolute Amount of Compounds in Their Storage and Screening Lifecycle. J Comb Chem 10 (2), 162-165, 2008.
Zhou H, Mu Q, Gao N, Liu A, Xing Y, Gao S, Zhang Q, Qu G, Chen Y, Liu G, Zhang B, Yan B*. A Nano-Combinatorial Library Strategy for the Discovery of Nanotubes with Reduced Protein-Binding, Cytotoxicity, and Immune Response. Nano Lett 8(3), 859-865, 2008.
Zhou H, Wu S, Zhai S, Liu A, Sun Y, Li R, Zhang Y, Ekins S, Swaan PW, Fang B, Zhang B, Yan B*. Design, Synthesis, Cytoselective Toxicity, Structure-Activity Relationships, and Pharmacophore of Thiazolidinone Derivatives Targeting Drug-Resistant Lung Cancer Cells. J Med Chem 51, 1242-1251, 2008.
Mu Q, Liu W, Xing Y, Zhou H, Li Z, Zhang Y, Ji L, Wang F, Si Z, Zhang B, Yan B*. Protein Binding by Functionalized Multiwalled Carbon Nanotubes Is Governed by the Surface Chemistry of Both Parties and the Nanotube Diameter. J Phys Chem C 112(9), 3300-3307, 2008.
Zhang B, Li X, Yan B*. Advances in HPLC detector-towards universal detection. Anal Bioanal Chem 390(1), 299-301, 2008.
Zhou H, Liu A, Li X, Ma X, Feng W, Zhang W, Yan B*. Microwave-Assisted Fluorous Synthesis of 2-Aryl-Substituted 4-Thiazolidinone and 4-Thiazinanone Libraries. J Comb Chem 10(2), 303-312, 2008.
Yu Z, Wang F, Milacic V, Li X, Cui QC, Zhang B, Yan B*, Dou QP.* Evaluation of copper-dependent proteasome-inhibitory And apoptosis-inducing activities of novel Pyrrolidine dithiocarbamate analogues. Int J Mol Med 20: 919-925, 2007.
Xu P, Qiu JH, Zhang YN, Chen J, Wang PG, Yan B, Song J, Xi Ri M, Deng ZX, Ma CQ. Efficient whole-cell biocatalytic synthesis of N-acetyl-D-neuraminic acid. Adv Syn Cat 349(10), 1614-1618, 2007.
Chen D, Cui QC, Yang H, Barrea RA, Sarkar FH, Sheng S, Yan B, Reddy GPV, Dou QP. Cliquinol, a Therapeutic Agent for Alzheimer’s Disease, Has Proteasome-inhibitory, Apoptosis-inducing and Anti-tumor Activities in Human Prostate Cancer Cells and Xenografts. Cancer Res 67(4):1636-44, 2007.
Zhai S, Liu W, Yan B.* Recent patents on treatment of severe acute respiratory syndrome (SARS). Recent Patents on Anti-Infective Drug Discovery 2(1), 1-10, 2007.
Chen L, Choo J, Yan B. The microfabricated electrokinetic pump: a potential promising drug delivery technique. Expert Opin Drug Deliv 4(2):119-129, 2007.
Yan B*, Shi R, Zhang B, Kshirsagar T. A Kinetic Study of Product Cleavage Reactions from the Solid Phase by a Biocompatible and Removable Cleaving Reagent, HCl. J Combi Chem 9(4), 684-689, 2007.
Yan B*, Zhao J, Leopold K, Zhang B, Jiang G. The Structure Dependent Response of Chemiluminescence Nitrogen Detector (CLND) for Organic Compounds with Adjacent Nitrogen Atoms Connected by a Single Bond. Anal Chem 79 (2) 718-726, 2007.
Landis-Piwowar KR, Milacic V, Chen D, Yang H, Zhao ZY, Chan TH, Yan B, Dou QP. Discovering novel anticancer drugs and chemo-sensitizers by using the proteasome as a potential target. Drug Resistance Update 9, 263-273, 2006.
Cheng X, Yan B, Gao L, Tang H, Fan Y, Anderson SN, Affleck R, Burns D. Compound transfer efficiency from polystyrene surfaces-application to microarrayed compound screening. J Biomolecular Screening 10(4), 293-303, 2005.
Irving M, Krueger CA, Wade JV, Hodges JC, Leopold K, Chan C, Shaqair S, Shornikov A, Stock M, Collins N, Yan B*. High-Throughput Purification of Combinatorial Libraries II: Automated Separation of Single Diastereomers from a 1920-Member 4-Amidopyrrolidinone Library. J Combi Chem 6, 478-486, 2004.
Yan B*, Collins N, Wheatley J, Irving M, Leopold K, Chan C, Shornikov A, Fang L, Lee A, Stock M, Zhao J. High-Throughput Purification of Combinatorial Libraries I: A High-Throughput Purification System Using an Accelerated Retention Window Approach. J Combi Chem 6, 255-261, 2004.
Last update: August 2009
