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Member, St. Jude Faculty
Director, High-Throughput Analytical Chemistry Facility
Chemical Biology & Therapeutics
Bing Yan, PhD
Chemical Biology & Therapeutics
MS 1000, Room E9064
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: bing.yan@stjude.org
Phone: (901) 595-2797
FAX: (901) 595-5715
PhD – Columbia University, New York, New York (1990)
Postdoc – Cambridge University
Postdoc – University of Texas Medical School at Houston
2010-2011
Jiao PF, Zhou HY, Otto M, Mu QX, Li LW, Su GX, Zhang Y, Butch E, Snyder S, Jiang GB, Yan B.* Leading Neuroblastoma Cells to Die by Multiple Premeditated Attacks from a Multifunctionalized Nanoconstruct. J Am Chem Soc 2011 (in press).
Li LW, Zhang Q, Liu AF, Li XE, Zhou HY, Liu Y, Yan B.* Proteome Interrogation Using Nanoprobes to Identify Targets of a Cancer-killing Molecule. J Am Chem Soc 2011 (in press).
Zhou HY, Jiao PF, Yang L, Li X, Yan B.* Enhancing Cell Recognition by Scrutinizing Cell Surfaces with a Nanoparticle Array. J Am Chem Soc 133(4):680-682, 2011.
Gao N, Zhang Q, Mu Q, Bai Y, Li L, Zhou H, Butch ER, Powell TB, Snyder SE, Jiang G, Yan B.*Steering Carbon Nanotubes to Scavenger Receptor Recognition by Nanotube Surface Chemistry Modification Partially Alleviates NFκB Activation and Reduces Its Immunotoxicity. ACS Nano 2011 (in press).
Zhou QF, Dergunov SA, Zhang Y, Li X, Mu QX, Zhang Q, Jiang GB, Pinkhassik F, Yan B.* Safety profile and cellular uptake of biotemplated nanocapsules with nanometer-thin walls. Nanoscale 2011 (in press).
Yan B. Impacts of Nanotechnology on Medicinal Chemistry and Drug Discovery. Current Medicinal Chemistry 2011 (in press).
Wu L, Yan B.* Discovery of Small Molecules that Target Autophagy for Cancer Treatment. Current Medicinal Chemistry 2011 (in press).
Li X, Zhou HY, Yang L, Du GQ, Pai-Panandiker A, Huang XF, Yan B.* Enhancement of Cell Recognition in vitro by Dual-Ligand Cancer Targeting Gold Naoparticles. Biomaterials 232:2540-2545, 2011.
Liu YY, Su GX, Zhang B, Jiang GB, Yan B.* Nanoparticle-Based Strategies for Detection and Remediation of Environmental Pollutants. Analyst 136(5):872-877, 2011. (Designated by Royal Society of Chemistry as one of the top five most-read articles from the online version of Analyst in the first month of publication; Selected by Royal Society of Chemistry blog/Journal of Materials Chemistry Blog as key reviews in “Materials for sensing and detection”).
Jiao P, Zhou H, Chen L, Yan B.* Cancer-Targeting Multifunctionalized Gold Nanoparticles in Imaging and Therapy. Current Medicinal Chemistry 2011 (in press).
Zhang RN, Bai YH, Zhang B, Chen LX, Yan B*. The Potential Health Risk of Titania Nanoparticles. Journal of Hazardous Materials 2011 (in press).
Tu Y, Yan B*. High-Throughput Fractionation of Natural Products for Drug Discovery. Chapter in Methods in Molecular Biology Book Series titled “High Throughput Phenotyping in Plants: Methods and Protocols”, 2011 (in press).
Mu QX, Zhang Y, Liu AJ, Liang NN, Liu YY, Mu Y, Su GX and Yan B*. Chapter 20. Safety Concerns for Nanomaterials in Nanomedicinal Applications. In Book Cancer Nanotechnology: Principles and Applications in Radiation Oncology by Taylor & Francis Group, 2011 (in press).
Yu C, Zhang J, Chen L*, Li J, Liu P, Wang W, Yan B*. “Off-On” Based Fluorescent Chemosensor for Cu2+ in Aqueous Media and Living Cells. Talanta 85(3):1627-1633, 2011.
Liu YJ, Zhang B, Yan B*. Enabling Anticancer Therapeutics by Nanoparticle Carriers: The Delivery of Paclitaxel. Int J Mol Sci 12(7):4395-4413, 2011.
Tekobo S, Richter AG, Dergunov SA, Pingali SV, Urban VS, Yan B, Pinkhassik E. Synthesis, Characterization, and Controlled Aggregation of Biotemplated Organic Nanodisks. J Nanoparticle Research Web Publication Date: May 11, 2011.
Yan B, Editorial: Nano-Combinatorial Chemistry and Associated Technologies, Combinatorial Chemistry & High Throughput Screening 14(3):146, 2011.
Liu Y, Yan B*. Characterizing the Surface Chemistry of Nanoparticles: An Analogy to Solid-Phase Synthesis Samples. Combinatorial Chemistry & High Throughput Screening 14(3):191-197, 2011.
Gasser M, Rothen-Rutishauser B, Krug HF, Gehr P, Nelle M, Yan B, Wick P. The Adsorption of Biomolecules to Multi-Walled Carbon Nanotubes is Influenced by Both Pulmonary Surfactant Lipids and Surface Chemistry. Journal of Nanobiotechnology 2011.
Wang GQ, Chen ZP, Wang WH, Yan B, Chen LX. Chemical Redox-Regulated Mesoporous Silica-Coated Gold Nanorods for Colorimetric Probing of Hg2+ and S2-. Analyst 136(1):174-178, 2011.
Wang F, Zhai SM, Liu XJ, Li LW, Wu S, Dou QP*, Yan B*. A Novel Dithiocarbamate Analogue with Potentially Decreased ALDH Inhibition has Copper-Dependent Proteasome-Inhibitory and Apoptosis¨CInducing Activity in Human Breast Cancer Cells. Cancer Letters 300(1):87-95, 2011.
Bai YH, Zhang Y, Zhang JP, Mu QX, Zhang WD, Butch ER, Snyder SE, Yan B.* Repeated Carbon Nanotube Administrations in Male Mice Cause Reversible Testis Damage without Affecting Fertility. Nature Nanotechnology 5(9):683-689, 2010. (Highlighted by Nature China, RSC Chemistry World, Nanowerk, Institute of Nanotechnology, Meridian Institute, and Softpedia.)
Yan B, Zhang B. Book: Analytical Methods in Combinatorial Chemistry, Second Edition, CRC Press, Taylor & Francis Group. ISBN: 978-0-8493-1860-3. Publication date: August 9, 2010.
Zhang Y, Bai Y, Yan B.* Functionalized Carbon Nanotubes for Potential Medicinal Applicatons. Drug Discovery Today 15(11-12):428-435, 2010.
Li LW, Mu QX, Zhang B, Yan B.* Analytical Strategies for Detecting Nanoparticle-Protein Interactions. Analyst 135(7):1519-1530, 2010. (Designated by Royal Society of Chemistry as one of the most-read articles from the online version of Analyst for the first month of publication).
Zhou HY, Li X, Lemoff A, Zhang B, Yan B.* Structural Confirmation and Quantification of Individual Ligands from the Surface of Multi-Functionalized Gold Nanoparticles. Analyst 135(6):1210-1213, 2010.
Mu QX, Yang L, Davis JC, Vankayala R, Hwang KC, Zhao JC, Yan B.* Biocompatibility of Polymer Grafted Core/Shell Iron/Carbon Nanoparticles. Biomaterials 31(19):5083-5090, 2010.
Tu Y, Jeffries C, Ruan H, Nelson C, Smithson D, Shelat AA, Brown KM, Li X-C, Hester JP, Smillie T, Khan IA, Walker L, Guy K*, Yan B.* An Automated High-Throughput System to Fractionate Natural Products for Drug Discovery. J Nat Prod 73(4):751-754, 2010. (Rated as the most read research article by ACS in the first four months of publication).
Su GX, Yan B.* Nano-Combinatorial Chemistry Strategy for Nanotechnology Research. J Comb Chem 12(2):215-221, 2010.
Zhang Q, Zhou HY, Zhai SM, Yan B.* Natural Product–Inspired Synthesis of Thiazolidine and Thiazolidinone Compounds and Their Anticancer Activities. Curr Pham Design 16(16):1826-1842, 2010.
Wang F, Jiao PF, Qi MH, Frezza M, Dou QP*, Yan B.* Turning Tumor-Promoting Copper into an Anti-Cancer Weapon via High-Throughput chemistry. Curr Med Chem 17(25):2685-2698, 2010.
Zhai SM, Yang L, Cui QZC, Sun Y, Dou QP*, Yan B.* Tumor Cellular Proteasome Inhibition and Growth Suppression by 8-Hydroxylquinoline and Clioquinol Requires Their Capabilities to Bind Copper and Transport Copper into Cells. J Biological Inorganic Chemistry 15(2):259-269, 2010.
Zhou HY, Zhang W, Yan B.* Use Cyclohexylisocyanide and Methyl 2-Isocyanoacetate as Convertible Isocyanides for Microwave-Assisted Fluorous Synthesis of 1,4-Benzodiazepine-2,5-Dione Library. J Comb Chem 12(1):206-214, 2010.
Zhang B, Yan B.* Analytical Strategies for Characterizing Nanoparticles Surface Chemistry. Anal Bioanal Chem, 396(3):973-982, 2010.
Last update: November 2011
