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Member, St. Jude Faculty
Endowed Chair of Biostatistics
Director, Biostatistics Shared Resource for the St. Jude Cancer Center
Executive Director, Operations and Biostatistics Center, Pediatric Brain Tumor Consortium
Biostatistics
James Boyett, PhD
Biostatistics
MS 768
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: james.boyett@stjude.org
Phone: (901) 595-4986
FAX: (901) 595-8843
BEE - Georgia Tech (1966)
MA - University of Alabama, Huntsville (1970)
MS - Michigan State University (1971)
PhD - Michigan State University (1974)
Mikkelsen TS, Sparreboom A, Cheng C, Zhou Y, Boyett JM, Raimondi SC, Panetta JC, Bowman WP, Sandlund JT, Pui CH, Relling MV, Evans WE. Shortening Infusion Time for High-Dose Methotrexate Alters Antileukemic Effects: A Randomized Prospective Clinical Trial. Journal of Clinical Oncology May 1: 29(13):1771-8, 2011. Epub 2011 Mar 28.
Gururangan S, Chi SN, Young Poussaint T, Onar-Thomas A, Gilbertson RJ, Vajapeyam S, Friedman HS, Packer RJ, Rood BN, Boyett JM, Kun LE. Lack of Efficacy of Bevacizumab Plus Irinotecan in Children with Recurrent Malignant Glioma and Diffuse Brainstem Glioma: A Pediatric Brain Tumor Consortium Study. Journal of Clinical Oncology, Jun 20:28(18):3069-75, 2010. Epub 2010 May 17. PMCID: PMC2903337
Prabhu SP, Ng S, Vajapeyam S, Kieran MW, Pollack IF, Geyer R, Haas-Kogan D, Boyett JM, Kun L, Poussaint TY. DTI Assessment of the Brainstem White Matter Tracts in Pediatric BSG Before and After Therapy: A Report from the Pediatric Brain Tumor Consortium. Childs Nerv Syst Jan;27(1):11-8, 2011. Epub 2010 Nov 4.
Warren KE, Goldman S, Pollack IF, Fangusaro J, Schaiquevich P, Stewart CF, Wallace D, Blaney SM, Parker R, Macdonald T, Jakacki R, Boyett JM, Kun LE. Phase I Trial of Lenalidomide in Pediatric Patients with Recurrent, Refractory, or Progessive Primary CNS Tumors: Pediatric Brain Tumor Consortium Study PBTC-018. Journal of Clinical Oncology Jan 20:29(3):324-9, 2011. Epub 2010 Dec 13. PMCID: PMC3056466
Zukotynski KA, Fahey FH, Kocak M, Alavi A, Wong TZ, Treves ST, Shulkin BL, Haas-Kogan DA, Geyer JR, Vajapeyam S, Boyett JM, Kun LE, Poussaint TY. Evaluation of 18F-FDG PET and MRI Associations in Pediatric Diffuse Intrinsic Brain Stem Glioma: A Report from the Pediatric Brain Tumor Consortium. J Nucl Med Feb 52(2):188-95, 2011. Epub 2011 Jan 13.
Pollack IF, Stewart CF, Kocak M, Poussaint TY, Broniscer A, Banerjee A, Douglas JG, Kun LE, Boyett JM, Geyer JR. A Phase II Study of Gefitinib and Irradiation in Children with Newly Diagnosed Brainstem Gliomas: A Report from the Pedatric Brain Tumor Consortium. Neuro Oncol Mar 13(3):290-7, 2011. Epub 2011 Feb 3. PMCID: PMC3064605
Poussaint TY, Kocak M, Vajapeyam S, Packer RI, Robertson RL, Geyer R, Haas-Kogan D, Pollack IF, Vezina G, Zimmerman R, Cha S, Patay Z, Boyett JM, Kun LE. MRI as a Central Component of Clinical Trials Analysis in Brainstem Glioma: A Report from the Pediatric Brain Tumor Consortium (PBTC). Neuro Oncol Apr 13(4):417-27, 2011. Epub 2011 Feb. 4. PMCID: PMC3064695
Haas-Kogan DA, Banerjee A, Poussaint TY, Kocak M, Prados MD, Geyer JR, Fouladi M, Broniscer A, Minturn JE, Pollack IF, Packer RJ, Boyett JM, Kun LE. Phase II Trial of Tipifarnib and Radiation in Children with Newly Diagnosed Diffuse Intrinsic Pontine Gliomas. Neuro Oncol Mar; 13(3):298-306, 2011. PMCID: PMC3064607
Zhao W, Boyett JM, Kocak M, Ellison D, Wu Y. Maximum Likelihood Estimation of Reviewers’ Acumen in Central Review Setting: Categorical Data. Theor Biol Med Model Mar 25:8(1):3, 2011. Epub ahead of print.
Fouladi M, Stewart CF, Blaney SM, Onar-Thomas A, Schaiquevich P, Packer RJ, Gajjar A, Kun LE, Boyett JM, Gilbertson RJ. Phase I Trial of Lapatinib in Children with Refractory CNS Malignancies: A Pediatric Brain Tumor Consortium Study. Journal of Clinical Oncology Sep 20;28(27):4221-7, 2010. Epub 2010 Aug 16. PMCID: PMC2953974
Geyer JR, Stewart CF, Kocak M, Broniscer A, Phillips P, Douglas JG, Blaney SM, Packer RJ, Gururangan S, Banerjee A, Kieran MW, Kun LE, Gilbertson RJ, Boyett JM. A Phase I and Biology Study of Gefitinib and Radiation in Children with Newly Diagnosed Brain Stem Gliomas or SupratentorialMalignant Gliomas. Eur J Cancer Aug 12, 2010. (Epub ahead of print). PMCID: PMC2988095
Asfar T, Klesges RC, Sanford SD, Sherrill-Mittleman D, Robison LL, Hudson MM, Somes G, Boyett JM, Lando H. Trial Design: The St. Jude Children’s Research Hospital Cancer Survivors Tobacco Quit Line Study. Contemporary Clinical Trials Jan; 31(1):82-91, 2010. Epub 2009 Sep 18. PMCID: PMC2818168
Onar A, Ramamurthy U, Wallace D, Boyett JM. An Operational Perspective of Challenging Statistical Dogma while Establishing a Modern, Secure Distributed Data Management and Imaging Transport System – The Pediatric Brain Tumor Consortium Phase I Experience. Clinical and Translational Science 2(2):143-149, 2009 PMCID: PMC2877373
Zhao W, Hevener KE, White SW, Lee RE, Boyett JM. A Statistical Framework to Evaluate Virtual Screening. BMC Bioinformatics Jul 20; 10:225, 2009. PMCID: PMC2722655
Pui C-H, Campana D, Pei D, Bowman PW, Sandlund JT, Kaste SC, Ribeiro RC, Rubnitz JE, Raimondi SC, Onciu M, Coustan-Smith E, Kun LE, Jeha S, Cheng C, Howard SC, Simmons V, Bayles A, Metzger ML, Boyett JM, Leung W, Downing JR, Evans WE, Relling MV. Treatment of Childhood Acute Lymphoblastic Leukemia without Prophylactic Cranial Irradiation. New England Journal of Medicine Jun 25; 360(26):2730-41, 2009. PMCID: PMC2754320
Xiong X, Boyett JM, Webster RG, Stech J. A Stochastic Model for Estimation of Mutation Rates in Multiple-Replication Proliferation Processes. J Math Biol Aug; 59(2):175-91, 2009. Epub Oct. 10, 2008. PMCID: PMC2692649
Onar A, Kocak M, Boyett JM. Continual Reassessment Method vs. Traditional Empirically Based Design: Modifications Motivated by Phase I Trials in Pediatric Oncology by the Pediatric Brain Tumor Consortium. Journal of Biopharmaceutical Statistics 19(3):437-55, 2009.
Sanders RP, Onar A, Boyett JM, Broniscer A, Morris ED, Qaddoumi I, Armstrong GT, Boop FA, Sanford RA, Kun LE, Merchant TE, Gajjar A. M1 Medulloblastoma: High Risk at Any Age. J Neurooncol Dec; 90(3):351-5, 2008. Epub August 15, 2008. PMCID: PMC2597631
Williams G, Fahey FH, Treves ST, Kocak M, Pollack IF, Boyett JM, Kun LE, Poussaint TY. Exploratory Evaluation of Two-Dimensional and Three-Dimensional Methods of FDG PET Quantification in Pediatric Anaplastic Astrocytoma: A Report from the Pediatric Brain Tumor Consortium (PBTC). Eur J Nucl Med Mol Imaging Sep; 35(9):1651-8, 2008. Epub April 19, 2008.
Fouladi M, Chintagumpala M, Ashley D, Kellie S, Gururangan S, Hassall T, Gronewold L, Stewart C, Wallace D, Broniscer A, Hale G, Kasow K, Merchant T, Morris B, Krasin M, Kun L, Boyett J, Gajjar A. Amifostine Protects Against Cisplatin-Induced Ototoxicity in Children with Average-Risk Medulloblastoma. Journal of Clinical Oncology August 1; 26(22):3749-55, 2008. PMCID: 2504739
Finlay JL, Dhall G, Boyett JM, Dunkel IJ, Gardner SL, Goldman S, Yates AJ, Rosenblum MK, Stanley P, Zimmerman RA, Wallace D, Pollack IF, Packer RJ. Myeloablative Chemotherapy with Autologous Bone Marrow Rescue in Children and Adolescents with Recurrent Malignant Astrocytoma: Outcome Compared with Conventional Chemotherapy: A Report from the Children’s Oncology Group. Pediatric Blood and Cancer Dec; 51(6):806-11, 2008.
Haas-Kogan DA, Banerjee A, Kocak M, Prados MD, Geyer RJ, Fouladi M, McKnight T, Young-Poussaint T, Broniscer A, Blaney SM, Boyett JM, Kun LE. Phase I Trial of Tipifarnib in Children with Newly Diagnosed Intrinsic Diffuse Brainstem Gliomas. Neuro-Oncology Jun; 10(3):341-7, 2008. Epub April 16, 2008.
Gururangan S, Turner CD, Stewart CF, O’Shaughnessy M, Kocak M, Poussaint TY, Phillips PC, Goldman S, Packer R, Pollack IF, Blaney SM, Karsten V, Gerson SL, Boyett JM, Friedman HS, Kun LE. Phase I Trial of VNP40101M (CLORETAZINE®) in Children with Recurrent Brain Tumors – A Pediatric Brain Tumor Consortium (PBTC) Study. Clinical Cancer Research Feb 15; 14(4):1124-30, 2008.
MacDonald TJ, Stewart CF, Kocak M, Goldman S, Ellenbogen RG, Phillips P, Lafond D, Young-Poussaint T, Broniscer A, Blaney SM, Boyett JM, Kun LE. Phase I Clinical Trial of Cilengitide (EMD 121974) in Clidren with Refractory Brain Tumors: A Pediatric Brain Tumor Consortium Study (PBTC-012). Journal of Clinical Oncology Feb 20; 26(6):919-24, 2008.
Broniscer A, Grurangan S, MacDonald TJ, Goldman S, Parker RJ, Stewart CF, Wallace D, Danks MK, Friedman HS, Poussaint TY, Kun LE, Boyett JM, Gajjar A. Phase I Trial of Single-Dose Temozolomide and Continuous Administration of 06-Benzylguanine in Children with Brain Tumors: A Pediatric Brain Tumor Consortium Report. Clinical Cancer Research Nov. 15; 13(22 Pt 1): 6712-8, 2007.
Poussaint TY, Phillips PC, Vajapeyam S, Fahey FH, Roberson RL, Osganian S, Ramamurthy U, Mulkern RV, Treves St, Boyett JM, Kun LE. The Neuroimaging Center of the Pediatric Brain Tumor Consortium-collaborative neuroimaging in pediatric brain tumor research: a work in progress. AJNR Am J Neuroradiol Apr; 28(4):603-7, 2007.
Hu XJ, Schroeder RJ, Wang WC, Boyett JM. Pseudoscore Based Estimation from Biased Observations. Statistics in Medicine June; 26(14): 2836-52, 2007.
Xiong X, Tan M, Boyett JM. A Sequential Procedure for Monitoring Clinical Trials Against Historical Controls. Statistics in Medicine 26(7):1497-511, 2007.
Gajjar A, Chintagumpala M, Ashley D, Kellie S, Kun LE, Merchant TE, Woo S, Wheeler G, Ahern V, Krasin MJ, Fouladi M, Broniscer A, Krance R, Hale G, Stewart CF, Dauser R, Sanford RA, Fuller C, Lau C, Boyett JM, Wallace D, Gilbertson RJ. Risk Adapted Craniospinal Radiotherapy Followed by High-Dose Chemotherapy and Stem-Cell Rescue in Children with Newly Diagnosed Medulloblastoma (St Jude Medulloblastoma-96): Long-Term Results From a Prospective, Multicentre Trial. The Lancet Oncology Oct; 7(10):813-20, 2006.
Last update: September 2011
