Education
PhD – Baylor College of Medicine, Houston, Texas
Research Interests
- Cellular and molecular regulation of hematopoietic stem cell in vivo repopulating activity
- Hematopoietic stem cell development and specification
- Hematopoietic stem cell fitness during chronic hematologic disease
Selected Publications
Ganuza M, Hall T, Myers J, Nevitt C, Sánchez-Lanzas R, Chabot A, Ding J, Kooienga E, Caprio C, Finkelstein D, Kang G, Obeng E, McKinney-Freeman S. Murine foetal liver supports limited detectable expansion of life-long haematopoietic progenitors. Nat Cell Biol Oct;24(10):1475-1486, 2022. PMID: 36202972
Hall TD, Kim H, Dabbah M, Myers JA, Crawford JC, Morales-Hernandez A, Caprio CE, Sriram P, Kooienga E, Derecka M, Obeng EA, Thomas PG, McKinney-Freeman S. Murine fetal bone marrow does not support functional hematopoietic stem and progenitor cells until birth. Nat Commun Sep 15;13(1):5403, 2022. PMID: 36109585
Goodings C, Zhao X, McKinney-Freeman S, Zhang H, Yang JJ. ARID5B influences B cell development and function in mouse. Haematologica Aug 4, 2022. PMID: 35924577
Bogeska R, Mikecin AM, Kaschutnig P, Fawaz M, Büchler-Schäff M, Le D, Ganuza M, Vollmer A, Paffenholz SV, Asada N, Rodriguez-Correa E, Frauhammer F, Buettner F, Ball M, Knoch J, Stäble S, Walter D, Petri A, Carreño-Gonzalez MJ, Wagner V, Brors B, Haas S, Lipka DB, Essers MAG, Weru V, Holland-Letz T, Mallm JP, Rippe K, Krämer S, Schlesner M, McKinney Freeman S, Florian MC, King KY, Frenette PS, Rieger MA, Milsom MD. Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging. Cell Stem Cell Aug 4;29(8):1273-1284.e8, 2022. PMID: 35858618
Ganuza M, Clements W, McKinney-Freeman S. Specification of hematopoietic stem cells in mammalian embryos: a rare or frequent event? Blood Jul 28;140(4):309-320, 2022. PMID: 35737920
Clapes T, Polyzou A, Prater P, Sagar, Morales-Hernández A, Ferrarini MG, Kehrer N, Lefkopoulos S, Bergo V, Hummel B, Obier N, Maticzka D, Bridgeman A, Herman JS, Ilik I, Klaeylé L, Rehwinkel J, McKinney-Freeman S, Backofen R, Akhtar A, Cabezas-Wallscheid N, Sawarkar R, Rebollo R, Grün D, Trompouki E. Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration. Nat Cell Bio Jul;23(7):704-717, 2021. PMID: 34253898
Bonner MA, Morales-Hernández A, Zhou S, Ma Z, Condori J, Wang YD, Fatima S, Palmer LE, Janke LJ, Fowler S, Sorrentino BP, McKinney-Freeman S. 3' UTR-truncated HMGA2 overexpression induces non-malignant in vivo expansion of hematopoietic stem cells in non-human primates. Mol Ther Methods Clin Dev May 1;21:693-701, 2021. PMID: 34141824
Morales-Hernández A, McKinney-Freeman S. GABA gets blood on its hands. Blood Feb 11;137(6):723-724, 2021. PMID: 33570609
Morales-Hernández A, Benaksas C, Chabot A, Caprio C, Ferdous M, Zhao X, Kang G, McKinney-Freeman S. GPRASP proteins are critical negative regulators of hematopoietic stem cell transplantation. Blood Apr 2;135(14):1111-1123, 2020. PMID: 32027737
Ganuza M, Hall T, Obeng EA, McKinney-Freeman S. Clones assemble! The clonal complexity of blood during ontogeny and disease. Exp Hematol Mar;83:35-47, 2020. PMID: 32006606
Ganuza M, Hall T, Finkelstein D, Wang YD, Chabot A, Kang G, Bi W, Wu G, McKinney-Freeman S. The global clonal complexity of the murine blood system declines throughout life and after serial transplantation. Blood May 2;133(18):1927-1942, 2019. PMID: 30782612
Ganuza M, Chabot A, Tang X, Wenjian B, Natarajan S, Carter R, Gawad C, Kang G, and Cheng Y and McKinney-Freeman S. Murine hematopoietic stem cell activity is derived from pre-circulation embryos but not yolk sacs. Nature Communications Dec 20;9(1):5405, 2018.
Morales-Hernandez A, Martinat A, Chabot A, Kang G, McKinney-Freeman S. Elevated oxidative stress impairs hematopoietic progenitor function in C57Bl/6 sub-strains. Stem Cell Reports Aug 14;11(2):334-347, 2018.
Hall T, Walker M, Ganuza M, Holmfeldt P, Bordas M, Kang G, Wenjian B, Palmer LE, Finkelstein D, McKinney-Freeman S. Nfix promotes survival of immature hematopoietic cells via regulation of c-Mpl. Stem Cells 36960:943, 2018.
Ganuza M, Hall T, Finkelstein D, Chabot A, Kang G, McKinney-Freeman S. Life-long hematopoiesis is established by hundreds of precursors throughout mammalian ontogeny. Nature Cell Biology Oct 19(10):1153-1163, 2017.
Ganuza M, Chabot A, Hadland B, Bernstein I, McKinney-Freeman S. Hemogenic endothelial precursors display heterogeneous hematopoietic potential ex vivo. Experimental Hematology Jul;51:25-35, 2017.
Ganuza M, McKinney-Freeman S. Hematopoietic stem cells under pressure. Current Opinions in Hematology. Jul;24(4):314-321, 2017.
McKinney-Freeman SL. A breath of fresh air for umbilical cord blood. Blood 128(25):2878-2880, 2016.
Holmfeldt P, Ganuza M, Marathe H, He B, Hall T, Pardieck J, Saulsberry AC, Cico A, Gaut L, McGoldrick D, Finkelstein D, Tan K, McKinney-Freeman S. Functional screen identifies novel regulators of hematopoietic stem cell repopulation. J Exp Med 213(3):433-49, 2016.
Li P, Lahvic JL, Binder V, Pugach EK, Riley EB, Tamplin OJ, Panigrahy D, Bowman TV, Heffner GC, McKinney-Freeman S, Schlaeger TM, Daley GQ, Zeldin DC, Zon LI. Epoxyeicosatrienoic acids enhance hematopoietic stem and progenitor cell specification and engraftment. Nature 523(7561):486-71, 2015.
Arora N, Wenzel PL, McKinney-Freeman SL, Ross SJ, Kim PG, Chou SS, Yoshimoto M, Yoder MC, Daley GQ. Effect of Developmental Stage of HSC and Recipient on Transplant Outcomes. Dev Cell 29(5):621-8, 2014.
Holmfeldt P, Pardieck J, Saulsberry A, Kumar-Nandakumar S, Finkelstein D, Gray JT, Persons DA, McKinney-Freeman SL. Nfix is a novel regulator of murine hematopoietic stem and progenitor cell survival. Blood 122(17):2987-96, 2013.
Gustafsson K, Heffner G, Wenzel PL, Curran M, Grawé J, McKinney-Freeman SL, Daley GQ, Welsh M. The Src Homology 2 Protein Shb Promotes Cell Cycle Progression In Murine Hematopoietic Stem Cells By Regulation Of Focal Adhesion Kinase Activity. Exp Cell Res 319(12):1852-64, 2013. PMID:23528453.
McKinney-Freeman S, Cahan P, Li H, Lacadie SA, Huang HT, Curran M, Loewer S, Naveiras O, Kathrein KL, Konantz M, Lengerke C, Zon LI, Collins JJ, Daley GQ. The transcriptional landscape of hematopoietic stem cell ontogeny. Cell Stem Cell 11(5):701-14, 2012. *Cover article.
Kim K, Doi A, Wen B, Ng K, Zhao R1, Cahan P, Kim J, Ji H, Ehrlich L, Yabuuchi A, Takeuchi A, Cunniff KC, Hongguang H, Mckinney-Freeman S, Naveiras O, Yoon T, Hanna J, Jaenisch R, Weissleder R, Orkin S, Weissman IL, Feinberg A, Daley GQ. Epigenetic memory in induced pluripotent stem cells. Nature 467:285-90, 2010.
Koo S, Huntly BJ , Wang Y, Chen J, Brumme K, Ball B, McKinney-Freeman SL, Yabuuchi A, Scholl C, Bansal D, Zon LI, Fröhling S, Daley GQ, Gilliland DG, Mercher T. Cdx4 is dispensable for murine adult hematopoiesis but promotes MLL-AF9-mediated leukemogenesis. Haematologica 95:1642-50, 2010.
Adamo L, Naveiras O, Wenzel PL, McKinney-Freeman S, Mack PJ, Gracia-Sancho J, Suchy-Dicey A, Yoshimoto M, Lensch MW, Yoder MC, García-Cardeña G, Daley GQ. Biomechanical forces promote embryonic haematopoiesis. Nature 459:1131-5, 2009.
McKinney-Freeman SL, Naveiras O, Yates F, Loewer S, Philitas M, Curran M, Park PJ, Daley GQ. Surface antigen phenotypes of hematopoietic stem cells from embryos and murine embryonic stem cells. Blood 114: 268-78, 2009.
McKinney-Freeman S, Naveiras O, Daley GQ. Isolation of Hematopoietic Stem Cells from Mouse Embryonic Stem Cells. Curr Protoc Stem Cell Biol Chapter 1:Unit 1F.3, 2008.
McKinney-Freeman S, Lengerke C, Jang I-H, Shea J, Schmitt S, Philitas M, Wang Y, Daley GQ. Modulation of embryonic stem cell-derived CD41+c-kit+ hematopoietic progenitors by ectopic expression of Cdx genes. Blood 111:4944-53, 2008. *Cover article.
Wang Y, Yabuuchi A, McKinney-Freeman S, Scott G, Ward T, Ray M, Ducharme DMK, Chawengsaksophak K, Archer TK, Daley GQ. Cdx gene deficiency compromises embryonic hematopoiesis in the mouse. PNAS 105:7756-61, 2008.
Lengerke C, Schmitt S, Bowman T, Maouche-Chretien L, McKinney-Freeman S, Jang I-L, Hammerschmidt M, Davidson AL, Green J, Zon LI and Daley GQ. BMP and Wnt Specify Hemogenic Mesoderm by Activation of the Cdx-Hox Pathway From Murine Embryonic Stem Cells. Cell Stem Cells 2:72-82, 2008.
McKinney-Freeman SL, Daley GQ. Towards hematopoietic reconstitution from embryonic stem cells: a sanguine future. Current Opinion in Hematology 14(4):343-347, 2007.
McKinney-Freeman S, Naveiras O, Daley GQ. Derivation of hematopoietic stem cells from murine embryonic stem cells. Journal of Visualized Science (2):162, 2007.
Bowman TV, McCooey AJ, Merchant AA, Ramos CA, Fonseca P, Poindexter A, Bradfute SB, Oliveira DM, Green R, Zheng Y, Jackson KA, Chambers SM, McKinney-Freeman SL, Norwood KG, Darlington G, Gunaratne PH, Steffen D, Goodell MA. Differential mRNA Processing in Hematopoietic Stem Cells. Stem Cells 24(9):662-70, 2006.
McKinney-Freeman SL. Phenotype and origin of human skeletal muscle-derived hematopoietic progenitors. Leukemia Research 29(4):363-4, 2005.
McKinney-Freeman SL, Goodell MA. Muscle-Derived Hematopoietic Stem Cells. In: The Handbook of Stem Cells, Volume 2: Adult and Fetal Stem Cells. Robert Lanza, ed. New York, NY: Elsevier Academic Press: 2004, p. 405.
McKinney-Freeman SL, Goodell MA. Circulating Hematopoietic Stem Cells Do Not Efficiently Home to Bone Marrow During Homeostasis. Experimental Hematology 32(9):868-76, 2004.
McKinney-Freeman SL, Majka S, Jackson KA, Norwood K, Hirschi K, Goodell MA. Altered Phenotype and Reduced Function of Muscle-Derived Hematopoietic Stem Cells. Experimental Hematology 31(9):806-14, 2003.
McKinney-Freeman SL, Jackson KA, Camargo FD, Ferrari G, Mavilio F, Goodell MA. Muscle-derived hematopoietic stem cells are hematopoietic in origin. Proceedings of the National Academy of Sciences 99(3):1341-6, 2002.
Bartemes KR, McKinney S, Gleich GJ, Kita H. Endogenous platelet-activating factor is critically involved in effector functions of eosinophils stimulated with IL-5 or IgG. Journal of Immunology 162(5):2982-9, 1999.
Last update: January 2023