Read feature articles from St. Jude and ALSAC. To read more topic-specific news releases, see Medicine and Science News or Fundraising and Donor News.

Dr. Paul Taylor named Howard Hughes Medical Institute investigator

J. Paul Taylor, M.D., Ph.D., of St. Jude Children's Research Hospital, has been recognized as one of the nation’s leading biomedical researchers by the Howard Hughes Medical Institute.

Scientists find defects caused by brain tumor mutations

St. Jude scientists show that mutations in the DDX3X gene lead to different molecular defects. The findings will aid efforts to develop more individualized therapy of medulloblastoma.

Preserving the power of glucocorticoids to fight leukemia

Researchers led by St. Jude scientists have identified a mechanism that helps leukemia cells resist glucocorticoids, a finding that lays the foundation for more effective treatment of cancer and possibly a host of autoimmune diseases.

A better tool for mining the cancer genome

St. Jude scientists have developed a significantly better computer tool for finding genetic alterations that play an important role in many cancers but were difficult to identify with whole-genome sequencing.

Finding a “brake” for inflammation

Researchers have identified a protein that offers a new focus for developing targeted therapies to tame the severe inflammation associated with multiple sclerosis, colitis and other autoimmune disorders.

Experiencing Doctors’ Day from another perspective

Clinical fellow Jason Schwartz, M.D., Ph.D., Oncology, a former St. Jude patient, discusses what it’s like to experience his first Doctors’ Day.

Measuring response to leukemia treatment may save more lives

Measuring treatment response proves to be a powerful tool for guiding leukemia therapy

Aggressive infant leukemia has surprisingly few genetic changes

Researchers with the St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project have completed the most comprehensive DNA analysis yet of the most common form of ALL in infants.

Genome reveals clues for better diagnosis and treatment of rare adrenal cancer

St. Jude scientists identify key molecular events in pediatric adrenocortical tumors. The findings could help clinicians identify most malignant subtypes and lead to better treatment.

Evidence grows that sun protection must start early and be a lifelong habit

The St. Jude Children’s Research Hospital—Washington University Pediatric Cancer Genome Project found that melanoma in some adolescent and adult patients involves many of the same genetic alterations and would likely respond to the same therapy.

Discovery may help reduce cancer drug’s side effects

Researchers have identified the first genetic variation that is associated with increased risk and severity of peripheral neuropathy following treatment with a widely used anti-cancer drug.

Basic question yields possible strategy for combating major tropical disease

Researchers like to ask basic questions about how the world and the things in it work. Answers to those questions can advance science and protect health.

Yearly pituitary screening helps childhood cancer survivors manage risk

St. Jude researchers have reported more evidence that many childhood cancer survivors need their pituitary function checked annually.

Digging deeper to save lives and hearing

Cisplatin is one of the most widely used anti-cancer drugs. Many patients treated with the drug also have serious side effects like hearing loss.

Danny's dream

Danny Thomas had a dream that one day no child would die in the dawn of life. Help us celebrate the 52nd anniversary of this lifesaving mission by watching and sharing this video of St. Jude's opening.

Drug side effects explained in patients of East Asian ancestry

St. Jude scientists have linked inherited variations in a second gene to reduced tolerance of a key cancer drug. Findings will aid efforts to improve chemotherapy safety and effectiveness.

Tumor suppressor protein helps immune system stay balanced

Scientists at St. Jude have discovered that a protein widely known for preventing tumors also helps regulatory T cells do their job.

A turning point in cancer immunology may spark new therapies

Tumors can harness healthy white blood cells to enhance their own growth and suppress attacks by the immune system. St. Jude researchers have discovered that the immune suppression is primarily the work of cells called monocytes.

Drug candidate destroys malaria in 48 hours

A new anti-malarial drug candidate triggers the immune system to rapidly destroy red blood cells infected by malaria parasites. Clinical trials are being planned to test its safety in humans.

Anniversaries: Why I am thankful for St. Jude

The Thanksgiving season and the month of November is a special time for Rebecca Rogers of the St. Jude Pathology Department. A former St. Jude patient, Rebecca discusses how St. Jude has allowed her to be thankful for the important anniversaries in her life.

Gene therapy provides life-changing relief from hemophilia

Gene therapy developed at St. Jude Children’s Research Hospital, University College London and the Royal Free Hospital has transformed life for 10 men with severe hemophilia B.

The power of phone calls for protecting the heart

For childhood cancer survivors, regular heart checkups can save lives. Yet despite the potential benefits, many survivors fail to get recommended checkups on schedule.

Launching a three-pronged attack against Ewing sarcoma

Scientists at St. Jude Children’s Research Hospital have discovered a promising new triple-drug therapy for Ewing sarcoma, a cancer of the bone and soft tissue.

Another reason for hope

Childhood acute lymphoblastic leukemia (ALL) treatment is one of the 20th Century’s great cancer success stories. Today more than 90 percent of children with ALL become long-term survivors, compared to just 4 percent in 1962 when St. Jude opened its doors.

Scrutinizing Stress

Children with cancer are tougher than you might assume.

On the Line

At St. Jude, central lines are everybody’s business.

Unhealthy lifestyle dramatically boosts health risks for childhood cancer survivors

Adult survivors of childhood cancer who don’t get enough exercise and eat an unhealthy diet more than double their chances of developing metabolic syndrome.

Attaching an “on” switch for protein regulation

Just as accessories like boots and gloves help humans adapt to their environment, St. Jude Children’s Research Hospital scientists have discovered a mechanism that serves as an “on” switch for the machinery that helps proteins accessorize.

New leads on hushing the “voices” of schizophrenia

A missing gene and the resulting slow connection between brain structures may leave individuals vulnerable to the “voices” that are a common symptom of schizophrenia.

A Mother’s Perspective about Melanoma

My 11-year-old daughter, Alyssa, is a cancer survivor. As we approach the two-year mark from when we first heard the words, “Your child has melanoma,” I think about how those four words have forever changed our family. We are different. Alyssa is different.

Molecule acts as umpire to make tough life-or-death calls

Cells may be small, but they are home to plenty of mystery and drama. Take the enzyme known as RIPK1. St. Jude Children’s Research Hospital scientists have just determined that after birth, RIPK1 functions like an umpire in cells, making the tough calls necessary to balance competing signals that determine if cells live or die.

Broken DNA is bad for the brain

DNA may be the cornerstone of life, but the molecule breaks all the time. To read DNA’s code or make more DNA, cells routinely nick and unwind the famous double helix using specialized enzymes. Free radicals and other stresses can also break DNA.

Winning the Race Against Frailty

What are the risks? How can we counteract them?

High-risk Leukemia: Blocking the Shuffle

St. Jude scientists develop a new treatment strategy that offers hope to children and adults with a form of high-risk leukemia.

For brain tumor patients, age matters

Scientists at St. Jude Children’s Research Hospital have more evidence that age matters when it comes to the devastating brain tumors called high-grade gliomas (HGGs).

Teen patients enjoy thrilling prom at St. Jude Children’s Research Hospital

For a few hours last night, St. Jude Children’s Research Hospital teen patients forgot about doctors’ appointments and instead danced, laughed and reveled at prom.

Can adult cancer drugs beat a childhood brain tumor?

Children with an aggressive form of the most common childhood brain tumor, medulloblastoma, face a tough prognosis. Effective treatments are limited, and long-term survival is poor. But new hope may be offered by a discovery from St. Jude Children’s Research Hospital involving a pair of drugs used to treat adult cancers.

Childhood cancer survivors face mounting health risks in midlife

The latest results from the Childhood Cancer Survivor Study reinforce the importance of lifelong health care for adult survivors of childhood cancer. St. Jude Children’s Research Hospital investigators led the study.

From Patient to Practitioner

Inspired by their St. Jude caregivers, seven former patients help others by pursuing careers in health care.

The Sound of Science

St. Jude researchers find clues to preventing hearing loss and other side effects of chemotherapy.

Grateful Hearts

“Our family owes everything to St. Jude. There is no doubt that if it weren’t for St. Jude, we would have buried our kids by now. No doubt.”

Brain tumor culprit caught

A hunt through billions of pieces of genetic information uncovers new clues on treatments for childhood ependymoma.

Predicting the outcome when flu strikes

We depend on the disease-fighting immune system to protect us from flu infections or to help us recover if we catch the virus. Now there is evidence the immune system can also help to predict which flu patients will develop severe symptoms and wind up in the hospital.

Happily ever after

When the doctors said that Christopher was cancer-free, his mother and her fiancé decided to get married at St. Jude, surrounded by their new family.

A Gummy in My Tummy

Chemo can make foods taste yucky. St. Jude staff have created special gummies that are delicious, fun and (don’t tell the kids) nutritious.

Acute Lymphoblastic Leukemia: Erasing the Survival Gap

National statistics show that African-American and Hispanic children with acute lymphoblastic leukemia (ALL) are less likely than white children to survive their disease. But at St. Jude, patients of all races and ethnic backgrounds have the same high rates of survival.

New twist discovered in Lou Gehrig’s disease

ALS remains incurable, but new insight into its causes gives reason to hope. A research team led by St. Jude Children’s Research Hospital revealed that mutations causing ALS have an unexpected toxic effect in human nerve cells.

The dream of Danny Thomas

On February 4, 1962, the dream of one young entertainer with a heart for hopeless causes became a reality with the opening of St. Jude Children's Research Hospital.

St. Jude creates promising new antibiotics

Antibiotic resistance is a growing global concern, especially in bacteria that cause serious diseases, such as tuberculosis (TB). TB kills 1.3 million people a year, and extremely drug-resistant TB has been reported in dozens of countries.

Study highlights resilience of young cancer patients

Despite having life-threatening illnesses, children and teens with cancer were no more likely than their healthy peers to report symptoms of post-traumatic stress disorder (PTSD).

World Cancer Day 2014, State of the Science at St. Jude Children’s Research Hospital

Accomplishments at St. Jude Children’s Research Hospital since last World Cancer Day are giving us new insights into the origins and possible treatment of the many and varied cancer subtypes and include published discoveries in genomics, pharmacogenomics, immunology and long-term survivorship.

The Teen Scene

Hospital staff help teens embrace and enhance their talents.

The Treasure Seekers

Scientists unearth genes driving a childhood brain tumor.

The Voices of HIV

Patients with HIV ensure their voices are heard.

Waking up the body’s defense system

Blood contains a large number of T cells, which act like soldiers that defend against infections and other invaders. When T cells detect a threat, they “wake up” and start multiplying into an army to destroy it. How T cells are triggered to multiply has been largely a mystery.

Stressing cancer out

Even cancer cells can feel stress. In fact, it can kill them. According to new research led by St. Jude Children’s Research Hospital, drugs that enhance a process called oxidative stress may offer a new way to combat an aggressive soft tissue tumor called rhabdomyosarcoma.

Helping Hands, Open Hearts

One St. Jude program offers caregivers and patients a break.

New clues for fighting Alzheimer’s disease

St. Jude Children’s Research Hospital scientists have made a surprising connection between a rare disorder that strikes young people and Alzheimer’s disease, a disease that usually affects older people.

Old flu virus still threatens

St. Jude Children’s Research Hospital scientists warn the flu virus that caused a pandemic in the 1950s remains a threat today. The risk is greatest for those under age 50; this group lacks immunity to the virus.