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Charles J. Sherr, MD, PhD
Members of this department attempt to understand how oncogenes, tumor suppressors and checkpoint monitors of cellular stress govern tumor initiation, progression, and responses to cancer therapy. Identifying key regulatory proteins, defining their mechanisms of action, and determining how they function within complex signaling networks continues to provide a better understanding of the fundamental processes controlling cell proliferation, apoptosis, cell migration, and metastasis. Emphasis is placed on mouse models of particular pediatric cancers, including medulloblastoma, neuroblastoma, and acute lymphoblastic leukemia. All faculty members participate in interdepartmental Program Project Grants and basic science programs of the St. Jude Children’s Research Hospital Comprehensive Cancer Center.
Tumor Cell Biology
MS 350, Room D5006
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Preferred contact method: email
Richard A. Ashmun, PhD4 Applications of flow cytometry and cell separation
Linda M. Hendershot, PhD2 ER quality control in development and disease
Chunliang Li, PhD Genome editing in cancer development
Martine F. Roussel, PhD1 Genes and microRNAs in brain tumors
Brenda Schulman, PhD1, 3 Cellular regulation by ubiquitin-like proteins
Charles J. Sherr, MD, PhD Tumor suppressor–dependent signaling networks