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Non-Therapeutic Protocol

COGTRN: Computerized Intervention for Amelioration of Cognitive Late Effects among Childhood Cancer Survivors

Type of Protocol/Clinical Study

Supportive Studies: Psychology

Description

Children and adolescents surviving cancers, such as brain tumors (BT) and acute lymphoblastic leukemia (ALL), are at risk for developing cognitive (thinking) problems after cancer treatment. These cognitive problems may include difficulties in a specific type of short-term memory, called working memory. Working memory (WM) is the ability to hold and manipulate information online; for example, when an individual mentally rehearses a phone number in order to dial it without writing it down. These difficulties are sometimes severe enough to cause problems in daily life and at school. Working memory is believed to be involved in learning, reasoning, and comprehension. Ways of avoiding or improving these working memory problems are needed.

A computer-based working memory intervention has been successful in children diagnosed with ADHD and stroke survivors. Individuals participating in the intervention showed improvements on working memory measures as well as more complex problem solving skills.

This is a research study on the effectiveness of an at-home, computer-based intervention in childhood cancer survivors. This computerized working memory intervention has been shown to help children, who are not cancer survivors, with working memory problems. Some people who have completed this intervention show changes in brain activity thought to support working memory. In this study, childhood cancer survivors will be randomly assigned to the working memory intervention or a passive waitlist (standard of care). Intervention participants will also partake in neuroimaging exams before and after the intervention.


Objectives

The goals of this study are:


Eligibility

Principal Investigator

Heather M. Conklin, PhD

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