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Department of Chemical Biology and Therapeutics

Department of Chemical Biology & Therapeutics


R. Kiplin Guy, PhD

Departmental Focus

The Chemical Biology and Therapeutics Department at St. Jude was established to facilitate discovery of new bioactive small molecules and to bridge the gap between the identification of newly discovered active compounds with modest efficacy and potency to highly active compounds that can be used as pharmacological tools or preclinical leads. Its mission is to discover and develop novel chemical entities that increase understanding of the pathophysiology of or function as therapeutic leads for the treatment of catastrophic pediatric illnesses.

The department applies state-of-the-art high throughput techniques used for industrial discovery and development of drugs to the discovery of pharmacological tools and drug candidates for catastrophic pediatric disease. St. Jude is currently recruiting scientists with significant experience in drug development to build a pipeline that runs from discovery biology laboratories at St. Jude through high throughput chemistry and screening facilities to lead development groups within the department. The output of the program will include unique tools for the study of disease, novel methods for drug discovery, and therapeutic lead compounds. 

Contact Us

Chemical Biology & Therapeutics
MS 1000, Room E9050
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678

Phone: (901) 595-5714
FAX: (901) 595-5715

Preferred contact method: email


Taosheng Chen, PhD, PMP®  Small-molecule transcription factor drug discovery

Naoaki Fujii, PhD  Medicinal chemistry, chemical biology, PDZ domain

R. Kiplin Guy, PhD  Chemical biology and orphan disease drug discovery

Richard E. Lee, PhD  Development of new chemotherapeutic agents

Tudor Moldoveanu, PhD  Programmed cell death in health and disease

Philip M. Potter, PhD  Anticancer drug hydrolysis by carboxylesterases

Fatima Rivas, PhD  Total synthesis and studies of natural products of medicinal interest

Anang A. Shelat, PhD  Multi-scale modeling of biological and chemical data