Tanja Mittag, PhD

    Tanja Mittag, PhD

    Assistant Member, St. Jude Faculty


    Structural Biology

    Contact Information

    Tanja Mittag, PhD
    Structural Biology
    MS 311, Room D1034F
    St. Jude Children's Research Hospital
    262 Danny Thomas Place
    Memphis, TN 38105-3678
    Email: tanja.mittag@stjude.org
    Phone: (901) 595-6261
    FAX: (901) 595-3032


    Diploma – Johann Wolfgang Goethe University, Frankfurt, Germany (2001)
    PhD – Johann Wolfgang Goethe University, Frankfurt, Germany (2004)
    Postdoctoral Training - The Hospital for Sick Children, Toronto, Canada

    Honors & Awards

    Research Interests

    Research Lab

    Selected Publications

    Nourse A, Mittag T. The cytoplasmic domain of the T-cell receptor zeta subunit does not form disordered dimers. J Mol Biol 426: 62-70, 2014.

    Forman-Kay JD, Mittag T. From sequence and forces to structure, function, and evolution of intrinsically disordered proteins. Structure 21:1492-1499, 2013.

    Tang X, Orlicky S, Mittag T, Pawson T, Csizmok V, Forman-Kay JD, Sicheri F, Tyers M. Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase. Proc Natl Acad Sci USA 109, 3287-3292, 2012.

    Mittag T, Marsh J, Grishaev A, Orlicky S, Lin H, Sicheri F, Tyers M, Forman-Kay JD. Structure-function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase. Structure 18:494-506, 2010. (Preview: R. Konrat (2010) The Meandering of Disordered Proteins in Conformational Space. Structure 18:416-419.)

    Mittag T, Kay LE, Forman-Kay JD. Protein dynamics and conformational disorder in molecular recognition. J Mol Recognit 23:105-116, 2010.

    Mittag T, Orlicky S, Choy WY, Tang X, Lin H, Sicheri F, Kay LE, Tyers M, Forman-Kay JD. Dynamic equilibrium engagement of a polyvalent ligand with a single site receptor. Proc Natl Acad. Sci USA 105:17772-17777, 2008.

    Borg M, Mittag T, Pawson T, Tyers M, Forman-Kay JD, Chan HS. Poly-electrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity. Proc Natl Acad. Sci USA 104:9650-9655, 2007.

    Mittag T, Forman-Kay JD. Atomic-level characterization of disordered protein ensembles. Curr Op Struct Biol 17:3-14, 2007.

    Mittag T, Franzoni L, Cavazzini D, Schaffhausen B, Rossi GL, Günther U. Retinol modulates site-specific mobility of apo-cellular retinol-binding protein to promote ligand binding. J Am Chem Soc 128:9844-9848, 2006.

    Koglin A, Mofid MR, Löhr F, Schäfer B, Rogov VV, Blum MM, Mittag T, Marahiel MA, Bernhard F, Dötsch V. Conformational switches modulate protein interactions in peptide antibiotic synthetases. Science 312:273-276, 2006.

    Mittag T, Schaffhausen B, Günther U. Tracing kinetic intermediates during ligand binding. J Am Chem Soc 126:9017-9023, 2004.

    Mittag T, Schaffhausen B, Günther U. Direct observation of protein ligand interaction kinetics. Biochemistry 42:11128-11136, 2003.

    Günther U, Mittag T, Schaffhausen B. Probing Src Homology 2 domain ligand interactions by differential line broadening. Biochemistry 41:11658-11669, 2002.

    Weber T, Schaffhausen B, Liu Y, Günther U. NMR structure of the N-SH2 domain of the p85 subunit of Phosphatidylinositide 3-Kinase complexed to a doubly phosphorylated peptide reveals a second phosphotyrosine binding site. Biochemistry 39:15860-15869, 2000.

    Last updated: March 2014