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View recent medicine and science-related news releases.
St. Jude researchers have identified an inherited variation in the NUDT15 gene that is strongly associated with a low tolerance for a drug that is a mainstay of pediatric ALL treatment. The finding is expected to impact ALL treatment. (Jun J. Yang, PhD)
St. Jude Children’s Research Hospital scientists show that the PTEN tumor suppressor protein is essential for proper regulatory T cell function; discovery offers new focus for improving treatment of autoimmune diseases. (Hongbo Chi, PhD)
Scientists from St. Jude Children’s Research Hospital and China Agricultural University identify the changes in H9N2 flu virus in chickens that could signal emergence of viruses with potential to trigger a pandemic. (Robert Webster, PhD)
St. Jude Children’s Research Hospital scientists used a novel strategy to find the white blood cells that tumors rely on to suppress the immune response; results provide foundation for efforts to improve immunotherapy. (Peter Murray, PhD)
St. Jude Children’s Research Hospital study identifies small group of patients at risk for intellectual decline after bone marrow transplantation; results set stage for new strategies to preserve IQ and fight cancer. (Sean Phipps, PhD)
An international research collaborative led by St. Jude Children’s Research Hospital reports that the rapid action of (+)-SJ733 will likely slow malaria drug resistance; human safety trials of the compound are planned. (R. Kiplin Guy, PhD)
St. Jude Children’s Research Hospital study found adults diagnosed with retinoblastoma as infants often performed better on tasks than survivors diagnosed at an older age; suggests brain may compensate for early insult. (Tara Brinkman, PhD)
Gene therapy pioneered by St. Jude Children’s Research Hospital, University College London and the Royal Free Hospital provides provided men with hemophilia B reliable relief from the bleeding disorder, paving the way for more active lifestyles
St. Jude Children’s Research Hospital-Washington University Pediatric Cancer Genome Project and Institut Curie-Inserm lead collaboration that lays the foundation for precision medicine against bone and soft tissue tumor
St. Jude Children’s Research Hospital-led national study finds that brief telephone counseling by advanced-practice nurses prompts more childhood cancer survivors to get recommended heart screenings. (Melissa Hudson, MD)
Richard Gilbertson, M.D., Ph.D., to direct scientific enterprise for the institution
St. Jude Children’s Research Hospital researchers have identified a promising new triple-drug combination therapy that exploits DNA repair problem in Ewing sarcoma tumors; clinical trials expected to open soon. (Michael Dyer, PhD, Anang Shelat, PhD, Elizabeth Stewart, MD)
St. Jude Children’s Research Hospital study finds diet may influence susceptibility to autoinflammatory disease in at-risk individuals by favoring intestinal bacteria that fuel or dampen inflammation. (Thirumala-Devi Kanneganti, PhD)
St. Jude Children’s Research Hospital study shows that adjusting treatment based on early response to chemotherapy boosts survival of young patients with Philadelphia chromosome-like acute lymphoblastic leukemia. (Ching-Hon Pui, MD)
St. Jude Children’s Research Hospital study has identified the cumulative dose of a widely used class of chemotherapy drugs that leaves young male cancer patients at risk for impaired sperm production as adults. (Daniel Green, MD)
Stage set to determine if drugs called tyrosine kinase inhibitors will extend the lives of patients with the high-risk acute lymphoblastic leukemia subtype; pediatric clinical trial scheduled to open by early 2015. (Charles Mullighan, MBBS(Hons), MSc, MD)
St. Jude Children’s Research Hospital-led study found naturally acquired mutations in the avian H3N8 flu virus allow the infection to spread in mammals via respiratory droplets; human immunity to the virus is lacking. (Stacey Schultz-Cherry, PhD)
Ching-Hon Pui, M.D., recognized for pioneering research and treatment of childhood leukemia, increasing childhood cancer survival rates around the globe. (Dr. Ching-Hon Pui)
St. Jude Children’s Research Hospital discovery lays the groundwork for a new class of antibiotics to fight multi-drug resistant Staphylococcus aureus and related bacteria that cause serious infections. (Charles Rock, PhD)
St. Jude Children’s Research Hospital study finds that few adult survivors of childhood cancer follow a heart-healthy lifestyle that protects against heart disease, diabetes and other health problems. (Kirsten Ness, PhD)
St. Jude is one of 15 recipients honored for supporting military personnel.
Patients become teachers through an innovative, clinic-based audio project of St. Jude Children’s Research Hospital that gives youth infected with HIV a chance to share their experiences with the diagnosis. (Aditya Gaur, MD)
A St. Jude Children’s Research Hospital study identifies the mechanism underlying a shape-shifting protein that assists in tumor suppression; results could aid cancer drug development. (Dr. Richard Kriwacki, PhD)
Downing, internationally recognized as a genome sequencing pioneer and member of the National Academy of Sciences’ Institute of Medicine, becomes sixth leader to serve at hospital’s helm. (James Downing, MD)
St. Jude Children’s Research Hospital scientists advance understanding of how cells manage their vast array of proteins and how system failures can lead to cancer and other diseases. (Brenda Schulman, PhD)
St. Jude Comprehensive Cancer Center receives “exceptional” score from National Cancer Institute—highest rating awarded to cancer centers.
Internationally recognized physician-scientists joining fight against devastating childhood diseases as hospital expands clinical and basic science research .
St. Jude Children’s Research Hospital scientists report that a disruption in a brain circuit may contribute to the auditory hallucinations of schizophrenia. (Stanislav Zakharenko, MD, PhD)
Leslie Robison, Ph.D., becomes the fifth researcher from St. Jude Children’s Research Hospital to receive the Pediatric Oncology Award.
St. Jude Children’s Research Hospital-led study reveals differences in the pneumococcal genome that explain why current vaccines aren’t better at protecting children with sickle cell disease from the bacterial infection. (Jason Rosch, PhD)
St. Jude Children’s Research Hospital solves mystery of enzyme’s role in cell survival, offering clues of how immune system fights infection and possible strategies to treat problems ranging from heart attack to cancer. (Douglas Green, PhD)
St. Jude Children’s Research Hospital analysis reveals how the protein p53, which triggers cancer cells to commit suicide, attaches to its regulatory molecule; findings could lead to drugs to unleash p53 to battle a range of cancers. (Richard Kriwacki, PhD, and Douglas Green, PhD)
The study of two rare childhood neurodegenerative diseases leads St. Jude Children’s Research Hospital scientists to a new source of DNA damage that may play a role in a wide range of health problems, including cancer. (Peter McKinnon, PhD)
Tumors shrank or disappeared in some patients with advanced neuroblastoma in a Phase I study of an immune therapy manufactured at St. Jude Children’s Research Hospital. (Fariba Navid, MD)
For the second consecutive year, St. Jude leads the list of places students and young professionals want to work
Brenda Schulman, Ph.D., of St. Jude Children’s Research Hospital, has been elected to the National Academy of Sciences (NAS). Membership in the academy is a widely accepted mark of excellence in science and is considered one of the highest honors a scientist can receive.
St. Jude is one of 30 finalists honored for supporting military personnel.
St. Jude again designated Center of Excellence for Influenza Research and Surveillance by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.
St. Jude Children’s Research Hospital-Washington University Pediatric Cancer Genome Project offers new leads to improved outcomes for children with high-grade glioma brain tumors; particularly youngest patients. (Suzanne Baker, PhD, and Jinghui Zhang, PhD)
St. Jude Children’s Research Hospital—Washington University Pediatric Cancer Genome Project finds TP53 gene is altered in nearly all osteosarcomas; results help explain how tumors withstand radiation therapy. (Michael Dyer, PhD, and Jinghui Zhang, PhD)
A St. Jude Children’s Research Hospital-led study identified two adult cancer drugs with potential to improve treatment of a high-risk childhood brain tumor; the drugs are now part of a pediatric clinical trial. (Martine Roussel, PhD)
St. Jude Children’s Research Hospital and the Childhood Cancer Survivor Study: Long-term follow-up of adult survivors of childhood cancer reinforces need for lifelong health surveillance for childhood cancer survivors. (Gregory Armstrong, MD)
St. Jude Children’s Research Hospital -Washington University Pediatric Cancer Genome Project identifies the most common genetic alteration yet in the brain tumor ependymoma; results offer clues for fighting other cancers. (Richard Gilbertson, MD, PhD, David Ellison, MD, PhD, Jinghui Zhang, PhD)
A study led by St. Jude Children’s Research Hospital identifies factors that predict flu severity in patients and sets the stage for more effective therapies to prevent flu complications and deaths (Paul Thomas, PhD)
A study led by St. Jude Children’s Research Hospital offers a new avenue for scientists to pursue in the quest for desperately needed treatments for ALS. (J. Paul Taylor, MD, PhD)
Research led by St. Jude Children’s Research Hospital scientists has produced new versions of an old antibiotic that are active against difficult-to-treat tuberculosis; offers new strategy for overcoming drug resistance. (Richard Lee, PhD)
St. Jude Children’s Research Hospital study suggests previous research overestimated PTSD in young cancer patients; new findings highlight the ability of children to adjust and even thrive in response to challenges. (Sean Phipps, PhD)
St. Jude Children’s Research Hospital has been recognized for the fourth consecutive year as one of FORTUNE magazine’s “100 Best Companies to Work For.”