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(St. Jude Reference #)
|Identification and Characterization of Novel Pneumococcal Choline Binding Protein, CBPG, and Diagnostic and Therapeutic Uses Thereof (SJ-98-0028)|
|Description||This invention describes the identification of a pneumococcal choline binding protein, CbpG, which can be used as an immunogenic polypeptide to develop a vaccine against Strep. pneumoniae. Alternatively, this polypeptide could be used as a therapeutic agent to block adhesion of the bacteria to the lining of the respiratory tract in patients already infected with the bacterium.|
|Keywords||CbpG, choline binding proteins, antibiotic-resistant bacteria, vaccine, pneumonia, Streptococcus pneumoniae|
|Granted Patents or Published Applications||U.S. Patent No. 6,495,139|
|Related Scientific References||Tuomanen, et al., “Pathogenesis of pneumococcao infection”, New Eng Jour Med 322:1280-1284 (1995);
Cundell and Tuomanen, “Receptor specificity of adherence of Streptococcus pneumoniae to human-typeII pneumocytes and vascular endothelial cells in vitro” Mircob Pathog 17:361-374 (1994);
Hoepelman and Tuomanen, “Consequences of microbial attachment: directing host cell functions with adhesions” Infect Immun 60:1729-33 (1992).
|Licensing Opportunities||We are currently seeking licensing opportunities in all fields for the development of this technology.|
Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.
Last update: September 2008