New Uses for Chloroquine and Chloroquine Analogs (SJ-02-0008 and SJ-05-0017)



Technology Name
(St. Jude Reference #)
New Uses for Chloroquine and Chloroquine  Analog
(SJ-02-0008 and SJ-05-0017)
Description The following new uses for chloroquine and chloroquine analogs are provided:
  • prevent hypoxia-reperfusion injury
  • protect against lethal, "low dose rate" radiation
  • treat metabolic syndrome (clinical trials ongoing)
Keywords chloroquine, metabolic syndrome, hypoxia-reperfusion injury, radiation
Granted Patents or Published Applications U.S. Patent Nos. 6,916,627; 7,108,992; 7,160,692; 7,279,290; and 8,440,695, Pending U.S. Pub. 2013/0296237
Related Scientific References

Bakkenist, C. et al. ” DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation”, Nature 421: 499-506 (2003); see also related commentary by Bartek, J. and Lukas, J., Nature 421: 486-488 (2003);

Kastan, M.B. and Bartek, J., “Cell-cycle checkpoints and cancer”, Nature 432: 316-323 (2004);

Schneider, J.G. et al., “ATM-dependent suppression of stress signaling reduces vascular disease inmetabolic syndrome”, Cell Metab.4: 377-389 (Nov. 2006); see also related commentary by Shoelson, S., Cell Metab.4: 337-338 (Nov. 2006).

Licensing Opportunities We are currently seeking nonexclusive licensing opportunities in the described fields for the development and use of this technology.
   

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Last update: April 2014