RAR331: Treatment of Childhood Nasopharyngeal Carcinoma with Neoadjuvant Chemotherapy and Concomitant Chemoradiotherapy


Solid Tumor : Nasopharyngeal carcinoma


Nasopharyngeal carcinoma is very rare in children. The nasopharynx is located in the upper part of the throat behind the nose. Air passes through it to the lungs and food passes through it as it is swallowed. An opening on each side of the nasopharynx leads in to an ear.

Because of the location of nasopharyngeal carcinoma, the tumor usually cannot be totally removed with surgery. When patients are diagnosed early and the tumor is small, the treatment is usually radiation therapy only. Patients with more advanced disease usually get chemotherapy and radiation therapy. These patients commonly have larger tumors, or cancer that has spread to the lymph nodes of the neck.

This study will involve the use of radiation therapy, chemotherapy, and chemoradiotherapy. Radiation therapy involves the use of high-energy x-rays or other types of radiation to kill cancer cells. Chemotherapy is the use of anti-cancer drugs to stop the growth of cancer cells. Chemoradiotherapy is chemotherapy given at the same time as radiation therapy.



For the current eligibility status of this clinical study, referring physicians must contact St. Jude Children's Research Hospital at 1-866-2ST-JUDE  (1-866-278-5833).


Wayne Furman, MD
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105 USA
Voice: 1-888-226-4343 or 901-595-4055
Fax: 901-595-4011

Referring or consulting physicians only:

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The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.