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    Rachel Brennan, MD

    Rachel C. Brennan, MD

    Assistant Member, St. Jude Faculty




    Solid Tumor

    Contact Information

    Rachel Brennan, MD
    Solid Tumor
    MS 260, Room C6066
    St. Jude Children's Research Hospital
    262 Danny Thomas Place
    Memphis, TN 38105-3678
    Phone: (901) 595-2220
    FAX: (901) 521-9005


    BA – Carroll College, Helena, Montana
    MD – Johns Hopkins University School of Medicine, Baltimore, Maryland
    Internship/Residency (Pediatrics) - Johns Hopkins Hospital
    Fellowship (Pediatric Hematology/Oncology) - St. Jude Children’s Research Hospital

    Research Interests

    Selected Publications

    Brennan RC, Furman W, Mao S, Wu J, Turner DC, Stewart CF, Santana V, McGregor LM. Phase I dose escalation and pharmacokinetic study of oral gefitinib and irinotecan in children with refractory solid tumors. Cancer Chemother Pharmacol Dec; 74(6):1191-8, 2014. [Epub 2014 Sep 26] PMID: 25257509

    Brinkman TM, Merchant TE, Li Z, Brennan R, Wilson M, Hoehn ME, Qaddoumi I, Phipps S, Srivastava D, Robison LL, Hudson MM, Krull KR. Cognitive function and social attainment in adult survivors of retinoblastoma: A report from the St. Jude Lifetime Cohort Study. Cancer Nov 24, 2014. [Epub ahead of print] PMID: 25421884

    Tse BC, Kaste SC, Brennan R, Orr B, Wilson MW. Enophthalmos and choroidal atrophy after intraophthalmic artery chemotherapy for retinoblastoma. Ophthalmology Oct 22, 2014. [Epub ahead of print] PMID 25439599

    Willard VW, Qaddoumi I, Chen S, Zhang H, Brennan R, Rodriguez-Galindo C, Wilson MW, Phipps S. Developmental and adaptive functioning in children with retinoblastoma: A longitudinal investigation. J Clin Oncol 32(25):2788-93, 2014. [Epub 2014 Jul 14]

    Sullivan EM, Wilson MW, Billups CA, Wu J, Merchant TE, Brennan RC, Haik BG, Rodriguez-Galindo C, Free TM, Given V, Qaddoumi I. Pathologic risk-based adjuvant chemotherapy for unilateral retinoblastoma following enucleation. J Pediatr Hematol Oncol Feb 26, 2014. [Epub ahead of print] PMID: 24577551

    McEvoy J, Nagahawatte P, Finkelstein D, Richards-Yutz J, Valentine M, Ma J, Mullighan C, Song G, Chen X, Wilson MW, Brennan RC, Pounds S, Becksfort J, Huether R, Lu C, Fulton RS, Fulton LL, Hong X, Dooling DJ, Ochoa K, Mardis ER, Wilson RK, Easton J, Zhang J, Downing JR, Ganguly A, Dyer MA. RB1 gene inactivation by chromothripsis in human retinoblastoma. Oncotarget Jan 11, 2014. [Epub ahead of print] PMID: 24509483

    Loh AHP, Brennan RC, Lang W, Hickey RJ, Malkas LH, Sandoval JA. Dissecting the PI3K signaling axis in pediatric solid tumors: novel targets for clinical integration. Front Oncol 3:93, 2013. PMCID: PMC3636761

    Bhagat S, Bass J, Qaddoumi I, Brennan R, Wilson M, Wu J, Galindo CR, Paglialonga A, Tognola G. Time-frequency analysis of transient-evoked otoacoustic emissions in children exposed to carboplatin chemotherapy. Audiol Neurootol 18(2):71-82, 2013. PMCID: PMC3777667

    McEvoy J, Ulyanov A, Brennan R, Wu G, Pounds S, Zhang J, Dyer MA. Analysis of MDM2 and MDM4 single nucleotide polymorphisms, mRNA splicing and protein expression in retinoblastoma. PLoS One 7(8):e42739, 2012. PMCID: PMC3423419

    Huddleston S, McNall-Knapp RY, Siatkowski M, Odom C, Brennan R, Wilson MW. A novel translocation t(11;13) (q21;q14.2) in a child with suprasellar primitive neuroectodermal tumor and retinoblastoma. Ophthalmic Genet 34(1-2):97-100, 2013. PMID: 22924820

    Qaddoumi IQ, Billups C, Tagen M, Stewart C, Wu J, Helton K, McCarville B, Merchant T, Brennan R, Free T, Given V, Haik B, Rodriguez-Galindo C, Wilson MWW. Topotecan and vincristine combination is effective against advanced bilateral intraocular retinoblastoma and has manageable toxicity. Cancer 118(22):5663-5670, 2012. PMCID: PMC3413782

    Brennan RC, Wilson MW, Kaste S, Helton K, McCarville B. Ultrasound and MRI of pediatric ocular masses. Pediatr Radiol 42(6):738-749, 2012. PMCID: PMC3530407

    Zhang J, Benavente CA, McEvoy J, Flores-Otero J, Ding L, Chen X, Ulyanov A, Wu G, Wilson M, Wang J, Brennan R, Rusch M, Manning AL, Ma J, Easton J, Shurtleff S, Mullighan C, Pounds S, Mukatira S, Gupta P, Neale G, Zhao D, Lu C, Fulton RS, Fulton LL, Hong X, Dooling DJ, Ochoa K, Naeve C, Dyson NJ, Mardis ER, Bahrami A, Ellison D, Wilson RK, Downing JR, Dyer MA. A novel retinoblastoma therapy from genomic and epigenetic analyses. Nature 481(7381):329-334, 2012. PMCID: PMC3289956

    McEvoy J, Flores-Otero J, Zhang J, Nemeth K, Brennan R, Bradley C, Krafcik F, Rodriguez-Galindo C, Wilson M, Xiong S, Lozano G, Sage J, Fu L, Louhibi L, Trimarchi J, Pani A, Smeyne R, Johnson D, Dyer MA. Coexpression of normally incompatible developmental pathways in retinoblastoma genesis. Cancer Cell 20(2):260-275, 2011. PMCID: PMC3551581

    Brennan R, Federico S, Bradley C, Zhang J, Flores-Otero J, Wilson M, Stewart C, Zhu F, Guy K, Dyer MA. Targeting the p53 pathway in retinoblastoma with subconjunctival nutlin-3a. Cancer Res 71(12):4205-4213, 2011. PMCID: PMC3116943

    Teitz T, Stanke J, Federico S, Bradley C, Brennan R, Zhang J, Johnson MD, Sedlacik J, Inoue M, Zhang Z, Hillenbrand C, Rehg JE, Frase S, Calabrese C, Finkelstein D, Dyer MA, Lahti JM. Preclinical models for neuroblastoma: Establishing a baseline for treatment. PLoS ONE 6(4):e19133, 2011. PMCID: PMC3084749

    Brennan RC, Helton KJ, Pei D, Cheng C, Inaba H, Metzger ML, Howard SC, Rubnitz JE, Ribeiro RC, Sandlund JT, Jeha S, Pui CH, Bhojwani D. Spinal epidural lipomatosis in children with hematologic malignancies. Ann Hematol 90(9):1067-1074, 2011. PMCID: PMC3169011

    Last updated: December 2014