Clayton Naeve, PhD

Clayton W. Naeve, PhD

Member, St. Jude Faculty
Senior Vice President & Chief Information Officer
Endowed Chair in Bioinformatics
Director, Hartwell Center for Bioinformatics and Biotechnology


Information Sciences


Hartwell Center

Contact Information

Clayton Naeve, PhD
Information Sciences/Administration
MS 278, Room D-1007D
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Phone: (901) 595-4449
FAX: (901) 595-2945


PhD - Colorado State University

Research Interests

Selected Publications

Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, Easton J, Chen X, Wang J, Rusch M, Lu C, Chen SC, Wei L, Collins-Underwood JR, Ma J, Roberts KG, Pounds SB, Ulyanov A, Becksfort J, Gupta P, Huether R, Kriwacki RW, Parker M, McGoldrick DJ, Zhao D, Alford D, Espy S, Bobba KC, Song G, Pei D, Cheng C, Roberts S, Barbato MI, Campana D, Coustan-Smith E, Shurtleff SA, Raimondi SC, Kleppe M, Cools J, Shimano KA, Hermiston ML, Doulatov S, Eppert K, Laurenti E, Notta F, Dick JE, Basso G, Hunger SP, Loh ML, Devidas M, Wood B, Winter S, Dunsmore KP, Fulton RS, Fulton LL, Hong X, Harris CC, Dooling DJ, Ochoa K, Johnson KJ, Obenauer JC, Evans WE, Pui CH, Naeve CW, Ley TJ, Mardis ER, Wilson RK, Downing JR, Mullighan CG. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature 481(7380:157-163, 2012.

Zhang J, Benavente CA, McEvoy J, Flores-Otero J, Ding L, Chen X, Ulyanov A, Wu G, Wilson M, Wang J, Brennan R, Rusch M, Manning AL, Ma J, Easton J, Shurtleff S, Mullighan C, Pounds S, Mukatira S, Gupta P, Neale G, Zhao D, Lu C, Fulton RS, Fulton LL, Hong X, Dooling DJ, Ochoa K, Naeve C, Dyson NJ, Mardis ER, Bahrami A, Ellison D, Wilson RK, Downing JR, Dyer MA. A novel retinoblastoma therapy from genomic and epigenetic analyses. Nature 481(7381):329-334, 2012.

Wang J, Mullighan CG, Easton J, Roberts S, Heatley SL, Ma J, Rusch MC, Chen K, Harris CC, Ding L, Holmfeldt L, Payne-Turner D, Fan X, Wei L, Zhao D, Obenauer JC, Naeve C, Mardis ER, Wilson RK, Downing JR, Zhang J. CREST maps somatic structural variation in cancer genomes with base-pair resolution. Nat Methods 8(8):652-654, 2011.

Chen X, Hale GA, Neale GA, Knowles J, Barfield RC, Wang YD; Kaushal D, Naeve DC, Srivastava DK, Tong X, Turner V, Naeve CW, Handgretinger R. A novel approach for the analysis of T-cell reconstitution by using a T-cell receptor beta-based oligonucleotide microarray in hematopoietic stem cell transplantation. Exp Hematol 35:831-841, 2007.

Obenauar JC, Denson J, Mehta PK, Su X, Mukatira S, Finkelstein DB, Xu X, Wang J, Ma J, Fan Y, Rakestraw KM, Webster RQ, Hoffmann E, Krauss S, Zheng J, Zhang Z, Naeve CW. Large-scale sequence analysis of avian influenza isolates. Science 311(5767):1576-1580, 2006.

Kuefer MU, Chinwalla V, Zeleznik-Le NJ, Behm FG, Naeve CW, Rakestraw KM, Raimondi C, Morris SW. Characterization of the MLL Partner Gene, AF15q14, involved in the t(11;15)(1q23;q14-15). Oncogene 22:1418-1424, 2003.

Yeoh E-J, Ross ME, Shurtleff SA, Williams KW, Patel D, Mahfouz R, Behm FG, Raimondi SC, Relling MV, Patel A, Cheng C, Campana D, Wilkins D, Zhou X, Li J, Liu H, Pui C-H, Evans WE, Naeve C, Wong L, Downing JR. Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell (1-2):133-143, 2002.

Patel DH, Crawford CR, Naeve CW, Belt JA. Cloning, genomic organization and chromosoma localization of the gene encoding the murine sodium-dependent, purine-selective, concentrative nucleoside transporter (CNT2). Gene 242(1-2):51-58, 2000.

Buck GA, Fox JW, Gunthorpe M, Hager KM, Naeve CW, Pon RT, Adams PS, Rush J. Design strategies and performance of custom DNA sequencing primers. Biotechniques 27:528-36, 1999.

Harada H, Harada Y, O’Brien DP, Rice DS, Naeve CW, Downing JR. HERF1, a novel hematopoietic specific RING-finger protein is required for terminal differentiation of erythroid cells. Mol Cell Biol 19:3808-15, 1999.

Bodner SM, Naeve CW, Rakestraw RM, Jones BG, Valentine VA, Valentine MB, Luthardt FW, Willman CL, Raimondi SC, Behm FG, Downing JR, Roussel MF, Sherr CJ, Look AT. Cloning and chromosomal localization of the gene encoding human cyclin D-binding Myb-like protein (hDMP1). Gene 229:223-8, 1999.

Hitzler JK, Witte D, Jenkins N, Naeve CW, Look AT, Morris SW. cDNA cloning, expression pattern, and chromosomal localization of Mlf1, murine homologue of a gene involved in MDS and AML. Am J Path 155:53-9, 1999.

Danks MK, Morton CL, Krull EJ, Cheshire PJ, Richmond LB, Naeve CW, Pawlik CA, Houghton PJ, Potter PM. Comparison of activation of CPT-11 by rabbit and human carboxylesterases for use in enzyme/prodrug therapy. Clin Cancer Res 5:917-924, 1999.

Zhang W, Siebert R, Yan M, Hinzmann B, Cui X, Xue L, Rakestraw RM, Naeve CW, Beckmann G, Weisenburger DD, Sanger WG, Nowotny H, Vesely M, Callet-Bauchu E, Salles G, Dixit VM, Rosenthal A, Schlegelberger B, Morris SW. Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32). Nature Genetics 22:1-6, 1999.

Kurosawa H, Inukai T, Inaba T, Goi K, Chang K-S, Sinjyo T, Rakestraw KM, Naeve CW, Look AT. Two Candidate Downstream Target Genes for E2A-HLF. Blood 93:321-332, 1999.

Potter PM, Pawlik CA, Morton CL, Naeve CW, Danks MK. Isolation and Partial Characterization of a cDNA encoding a rabbit liver carboxylesterase that activates the prodrug Irinotecan (CPT-11). Cancer Res 58:2646-2651, 1998.

Crawford CR, Patel DH, Naeve C, Belt JA. Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line. J Biochem 273:5288-5293, 1998.

Ivanetich KM, Bibbs L, Niece RL, Denslow ND, Naeve CW, Rohde M, Ericsson LH. Commercial biotech instrumentation survey on performance, support, service. Genetic Engineering News 17:17, 1997.

Morris SW, Naeve C, Mathew P, Kirstein MN, Cui X, Witte DP. ALK, the chromosome 2 gene locus altered by the t(2:5) in non- Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK). (Erratum to document cited in CA127:91137). Oncogene 15(23):2883-2883, 1997.

Wilkinson DA, Neale GAM, Mao S, Naeve CW, Goorha RM. Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia. Leukemia 11:86-96, 1997.

Pon RT, Buck GA, Hager KM, Naeve CW, Niece RL, Robertson M, Smith AJ. A multi-facility survey of oligonucleotide synthesis and an examination of the performance of unpurified primers in automated DNA sequencing. BioTechniques 21:680-685, 1996.

Kuefer MU, Look AT, Williams DC, Valentine V, Naeve CW, Behm FG, Mullersman JE, Yoneda-Kato N, Montgomery K, Kucherlapati R, Morris SW. cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2). Genomics 35(2):392-396, 1996.

Naeve CW, Buck GA, Niece RL, Pon RT, Robertson M, Smith AJ. Accuracy of automated DNA sequencing: a multi-laboratory comparison of sequencing results. Biotechniques 19(3):448-453, 1995.

Hardy CT, Young SA, Webster RG, Naeve CW, Owens RJ. Egg fluids and cells of the chorioallantoic membrane of embryonated chicken eggs can select different variants of influenza A (H3N2) viruses. Virology 211(1):302-306, 1995.

Last update: October 2012