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(St. Jude Reference #)
|Mina, an IL-4 Repressor, a Predictor of Atopic Diseases, such as Allergic Rhinitis, Bronchial Asthma and Atopic Dermatitis (SJ-08-0005)|
|Description||Bronchial asthma and allergic rhinitis are diseases associated with elevated IL-4 production from dysregulated T helper 2 (TH2) cells. Researchers at St. Jude Children's Research Hospital and the RIKEN Yokohama Institute have discovered that Mina regulates the amount of IL-4 produced and that single nucleotide polymorphisms (SNPs) in the Mina locus are associated with asthma and rhinitis. Thus, Mina could be used as a genetic marker to predict susceptibility and diagnosis of allergic diseases and to screen for compounds useful as therapeutic agents.|
|Keywords||Mina, asthma, rhinitis, allergic diseases|
|Granted Patents or Published Applications||U.S. Patent Pub. 2011/0269125|
|Related Scientific References||Mariko Okamoto, Melanie Van Stry, Linda Chung, Madoka Koyanagi, Xizhang Sun, Yoshie Suzuki, Osamu Ohara, Hiroshi Kitamura, Atsushi Hijikata, Masato Kubo & Mark Bix; Mina, an Il4 repressor, controls T helper type 2 bias; Nature Immunology 10, 872 - 879 (2009)|
|Licensing Opportunities||We are currently seeking licensing opportunities in all fields for the development of this technology.|
Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.
Last update: April 2014