Stanley Pounds, PhD

    Stan Pounds, PhD

    Member, St. Jude Faculty
    Director, Division of Biostatistics for Computational Biology and Bioinformatics

    Departments

    Biostatistics

    Contact Information

    Stan Pounds, PhD
    Biostatistics
    MS 768, Room R6005
    St. Jude Children's Research Hospital
    262 Danny Thomas Place
    Memphis, TN 38105-3678
    Email: stanley.pounds@stjude.org
    Phone: (901) 595-5052
    FAX: (901) 595-8843

    Education

    BS - Harding University, Searcy, Arkansas (1997)
    PhD - Texas A&M University, College Station, Texas (2002)


    Research Interests

    I develop statistical methods for genomics studies conducted at St. Jude. I develop methods to estimate the false discovery rate (FDR), perform power and sample size calculations for microarray studies, pre-process SNP microarray data, detect genomic lesions using SNP microarray data, and explore the association microarray data with multiple clinical variables simultaneously.


    Selected Publications

    Robinson G, Parker M, Kranenburg TA, Lu C, Chen X, Ding L, Phoenix TN, Hedlund E, Wei L, Zhu X, Chalhoub N, Baker SJ, Huether R, Kriwacki R, Curley N, Thiruvenkatam R, Wang J, Wu G, Rusch M, Hong X, Becksfort J, Gupta P, Ma J, Easton J, Vadodaria B, Onar-Thomas A, Lin T, Li S, Pounds S, Paugh S, Zhao D, Kawauchi D, Roussel MF, Finkelstein D, Ellison DW, Lau CC, Bouffet E, Hassall T, Gururangan S, Cohn R, Fulton RS, Fulton LL, Dooling DJ, Ochoa K, Gajjar A, Mardis ER, Wilson RK, Downing JR, Zhang J, Gilbertson RJ. Novel mutations target distinct subgroups of medulloblastoma. Nature June 20, 1012.

    Rubnitz JE, Inaba H, Dahl G, Ribeiro RC, Bowman WP, Taub J, Pounds S, Razzouk BI, Lacayo NJ, Cao X, Meshinchi S, Degar B, Airewele G, Raimondi SC, Onciu M, Coustan-Smith E, Downing JR, Leung W, Pui CH, Campana D. Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: results of the AML02 multicentre trial. Lancet Oncol May 5, 2010.

    Pounds S, Cheng C, Cao X, Crews KR, Plunkett WA, Gandhi V, Rubnitz JE, Ribeiro RC, Downing JR, Lamba J. PROMISE: A Tool to Identify Genomic Variables with a Specific Biologically Interesting Pattern of Associations with Multiple Endpoint Variables. Bioinformatics 2009 (in press).

    Lamba JK, Pounds S, Cao X, Downing JR, Campana D, Ribeiro RC, Pui CH, Rubnitz JE. Coding polymorphisms in CD33 influence response to gemtuzumab ozogamicin in pediatric patients with AML: a pilot study. Leukemia 23:42-44, 2009.

    Yang J, Cheng C, Yang W, Pei D, Cao X, Fan Y, Pounds S, Treviño LR, French D, Campana D, Downing JR, Evans WE, Pui C-H, Devidas M, Bowman WP, Camitta BM, Willman C, Davies SM, Borowitz MJ, Carroll WL, Hunger SP, and Relling MV. Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. Journal of the American Medical Association 301: 393-403, 2009.

    Pounds S, Cheng C, Mullighan C, Raimondi SC, Shurtleff S, Downing JR. Reference Alignment of SNP Microarray Signals for Copy Number Analysis of Tumors. Bioinformatics 25: 315-321, 2009.  [Normalization Software]

    Pounds SB, Rai SN. Assumption Adequacy Averaging as a Concept to Develop More Robust Methods for Differential Gene Expression Analysis. Computational Statistics and Data Analysis 53: 1604-1612, 2008. (Special Issue on Statistical Genomics). [Associated Software]

    Pounds S, Cheng C, Onar A. Statistical Inference for Microarray Studies. In The Handbook of Statistical Genetics, 3rd edition. Balding, DJ, Cannings C, and Bishop, M eds. Wiley: New York. 2007.

    Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, Dalton JC, Girtman K, Mathew S, Ma J, Pounds SB, Su X, Pui C-H, Relling MV, Evans WE, Shurtleff SA, Downing JR. Genes regulating B cell development are mutated in acute lymphoid leukaemia. Nature 446: 758-764, 2007.  [Normalization Software]

    Lamba J, Crews K, Pounds S, Gresham J, Schuetz EG, Gandhi V, Plunkett W, Rubnitz J, Ribeiro R. Pharmacogenetics of Deoxycytidine Kinase: Identification and Characterization of Novel Genetic Variants. Journal of Pharmacology and Experimental Therapeutics 323: 935-45, 2007..

    Hartford C, Yang W, Cheng C, Fan Y, Liu W, Trevino L, Pounds S, Neale G, Raimondi SC, Bogni A, Dolan ME, Pui C-H, Relling MV. Genome scan implicates adhesion biological pathways in secondary leukemia. Leukemia 21: 2128-2136, 2007.

    West AN, Neale GA, Pounds S, Figueredo BC, Rodriguez-Galindo C, Alboney M, Pianovski D, Oliveira-Filho AG, Malkin D, Lalli E, Ribeiro R, Zambetti GP. Gene Expression Profiling of Childhood Adrenocortical Tumors. Cancer Research 67: 600-608, 2007.

    Pounds S, Cheng C. Robust Estimation of the False Discovery Rate. Bioinformatics 22: 1979 - 1987, 2006.  [Associated Software]

    Pounds S, Cheng C. Sample Size Determination for the False Discovery Rate. Bioinformatics 21: 4263-4271, 2005[Associated Software]

    Pounds S, Cheng C. Statistical Development and Evaluation of Gene Expression Data Filters. Journal of Computational Biology 12: 482-495, 2005.  [Associated Software]

    Ribeiro RC, Razzouk B, Pounds S, Hijiya N, Pui C-H, Rubnitz J. Successive Clinical Trials for Childhood Acute Myeloid Leukemia at St. Jude Children’s Research Hospital, 1980 through 2000. Leukemia 19: 2125–2129, 2005.

    Ross, ME, Mahfouz R, Liu HC, Zhou X, Song G, Shurtleff S, Pounds S, Cheng C, Ma J, Ribiero RC, Rubnitz JE, Girtman K, Williams WK, Raimondi SC, Liang DC, Shih LY, Pui C-H, Downing JR. Gene Expression Profiling of Pediatric Acute Myleogenous Leukemia. Blood 104, 3679-3687, 2004.

    Pounds S, C Cheng. Improving False Discovery Rate Estimation. Bioinformatics 20, 1737-1745, 2004[Associated Software]

    Pounds S, Morris S. Estimating the Occurrence of False Positives and False Negatives in Microarray Studies by Approximating and Partitioning the Empirical Distribution of p-values. Bioinformatics 19:1236-1242, 2003[Associated Software]

    Coustan-Smith E, Ribeiro RC, Rubnitz JE, Razzouk BI, Pui C-H, Pounds S, Andreansky M, Behm FG, Raimondi SC, Shurtleff SA, Downing JR, Campana D. Clinical Significance of Residual Disease During Treatment in Childhood Acute Myleoid Leukemia. British Journal of Haematology 123: 243-252, 2003.

    Last update: June 2012