Jason Rosch, PhD

    Jason W. Rosch, PhD

    Assistant Member, St. Jude Faculty


    Infectious Diseases

    Contact Information

    Jason Rosch, PhD
    Infectious Diseases
    MS 320, Room E8002
    St. Jude Children's Research Hospital
    262 Danny Thomas Place
    Memphis, TN 38105-3678
    Email: jason.rosch@stjude.org
    Phone: (901) 595-5633
    FAX: (901) 595-3099


    BA – The College of Wooster, Wooster, Ohio
    PhD – Washington University, St. Louis, Missouri

    Research Interests

    Selected Publications

    Mann B, van Opijen T, Wang J, Obert C, Wang Y, Carter R, McGoldrick DJ, Ridout G, Camilli A, Tuomanen EI, Rosch JW. Control of Virulence by small RNA in Streptococcus pneumonia. PLOS Pathogens 8(7):e1002788, 2012.

    Lebensburger JD, Howard T, Hu Y, Pestina TI, Gao G, Johnson M, Zakharenko SS, Ware RE, Tuomanen EI, Persons DA, Rosch JW. Hydroxyurea therapy of a murine model of sickle cell anemia inhibits the progression of pneumococcal disease by down-modulating E-selectin. Blood 23;119(8):1915-21, 2012.

    Rosch JW, Boyd AR, Hinojosa E, Pestina T, Hu Y, Persons DA, Orihuela CJ, Tuomanen EI. Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease. J Clin Invest 120:627-635, 2010.

    Rosch JW, Gao G, Ridout G, Tuomanen E. Role of the manganese efflux system mntE for signaling and pathogenesis in Streptococcus pneumoniae. Mol Microbiol 72:12-25, 2009.

    Kline KA, Kau AL, Chen SL, Lim A, Pinkner JS, Rosch J, Nallapareddy SR, Murray BE, Henriques-Normark B, Beatty W, Caparon MG, Hultgren SJ. Mechanism for sortase localization and role in efficient pilus assembly in Enterococcus faecalis. J Bacteriol 191:3237-3247, 2009.

    Rosch JW, Sublett J, Gao G, Wang Y, Tuomanen E. Calcium efflux is essential for bacterial survival in the eukaryotic host. Mol Microbiol 70:435-444, 2008.

    Rosch JW, Mann B, Sublett J, Tuomanen E. Convergence of regulatory pathways on the pilus locus of Streptococcus pneumoniae. Infect Immun 76:3187-3196, 2008.

    Rosch JW, Vega L, Beyer J, Lin A, Caparon MG. The signal recognition particle pathway is required for virulence in Streptococcus pyogenes. Infect Immun 76:2612-2619, 2008.

    Rosch JW, Tuomanen E. Adapting a diet from sugar to meat: double dealing genes of Streptococcus pyogenes. Mol Microbiol 64:257-259, 2007.

    Rosch JW, Hsu FF, Caparon MG. Anionic lipids enriched at the ExPortal of Streptococcus pyogenes. J Bacteriol 189:801-806, 2007.

    Rosch JW, Caparon MG. The ExPortal: An organelle for protein secretion and biogenesis in Streptococcus pyogenes. Mol Microbiol 58:959-968, 2005.

    Rosch J, Caparon M. A microdomain for protein secretion in gram-positive bacteria. Science 304:1513-1515, 2004.

    Last update: February 2013