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Solid Tumor : Recurrent / refractory neuroblastoma
This study is being done to find out if it is safe to give an antibody called hu14.18K322A (anti-GD2 antibody) together with Natural Killer (NK) cell infusions from a donor (usually a parent or other close relative) to children and adolescents with neuroblastoma in combination with chemotherapy.
Relapsed and/or refractory neuroblastoma is difficult to treat and cure. For this study we are adding two investigational treatments to standard chemotherapy to see if it is feasible (safe and possible) to give to patients with neuroblastoma. The first experimental treatment involves the use of a new experimental (investigational) antibody called hu14.18K322A. This antibody is manufactured at the Children’s GMP, LLC, which is here at St. Jude. The second experimental treatment uses donor natural killer (NK) cells together with chemotherapy. NK cells are special cells in our immune system that specifically target cancer cells and cells that are infected by viruses.
A patient will not be eligible to participate in the study if they are pregnant or breast-feeding or the research participant or legal guardian/representative are unable or unwilling to give written informed consent.
For the current eligibility status of this clinical study, referring physicians must contact St. Jude Children's Research Hospital at 1-866-2ST-JUDE (1-866-278-5833).
Wayne Furman, MD
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105 USA
Voice: 1-888-226-4343 or 901-595-4055
Referring or consulting physicians only: firstname.lastname@example.org
For all other inquiries about St. Jude Children's Research Hospital studies: email@example.com
The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.