Richard J. Gilbertson, MD, PhD

Richard J. Gilbertson, MD, PhD

Member, St. Jude Faculty
Director, Comprehensive Cancer Center and EVP
Director, Division of Brain Tumor Research

Departments

Developmental Neurobiology
Oncology

Contact Information

Richard Gilbertson, MD, PhD
Developmental Neurobiology
Room D2006G
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: richard.gilbertson@stjude.org
Phone: (901) 595-3913
FAX: (901) 595-2270

Research Interests

The principal aim of my research is to reduce the morbidity and mortality of children with central nervous system tumors through improved understanding of tumor biology. We hope to achieve this goal by:


Selected Publications

Atkinson J, Gilbertson RJ. Developing treatment strategies for rare cancers. Oncotarget 2(9):657, 2011.

Atkinson JM, Shelat AA, Carcaboso AM, Kranenburg TA, Arnold A, Wright KD. Johnson RA, Poppleton H, Mohankumar KM, Feau C, Phoenix T, Gibson P, Zhu L, Tong Y, Eden C, Ellison DW, Priebe W, Koul D, Yung WKA, Gajjar A, Stewart CF, Guy RK, Gilbertson RJ. An integrated in vitro and in vivo high throughput screen identifies treatment leads for ependymoma. Cancer Cell 20:384-99, 2011.

Gilbertson RJ. Mapping Cancer Origins. Cell 145 :25-9, 2011.

Gibson P, Tong, Y, Robinson G, Thompson MC, Currle DS, Eden C, Kranenburg TA, Hogg T, Poppleton H, Martin J, Finkelstein D, Pounds S, Weiss A, Patay Z, Scoggins M, Ogg R, Pei Y, Yang Z-J, Brun S, Lee Y, Zindy F, Lindsey JC, Taketo MM, Boop FA, Sanford RA, Gajjar A, Clifford SC, Roussel MF, McKinnon PJ, Gutmann DH, Ellison DW, Wechsler-Reya R, Gilbertson RJ. Subtypes of medulloblastoma have distinct developmental origins. Nature 468:1095-9. 2010.

Famulski JK, Trivedi N, Howell D, Yang Y, Tong Y, Gilbertson RJ, Solecki DJ. Siah Regulation of Pard3A Controls Neuronal Cell Adhesion During Germinal Zone Exit. Science 330:1834-8, 2010.

Johnson RA, Wright KD, Poppleton H, Mohankumar KM, Finkelstein DF, Pounds SB, Rand V, Leary SE, White E, Eden C, Hogg T, Northcott P, Mack S, Neale G, Wang M, Coyle B, Atkinson J, DeWire M, Kranenburg TA, Gillespie Y, Allen JC, Merchant T, Boop FA, Sanford RA, Gajjar A, Ellison DW, Taylor MD, Grundy RG, Gilbertson RJ. Cross-species genomics matches driver mutations and cell compartments to model ependymoma. Nature 466: 632–636, 2010.

Fouladi M, Stewart CF, Blaney SM, Onar-Thomas A, Schaiquevich P, Packer RJ, Gajjar A, Kun LE, Boyett JM, Gilbertson RJ. A Phase I Trial of Lapatinib In Children With Refractory CNS Malignancies: A Pediatric Brain Tumor Consortium Study. J Clin Oncol 28:4221-7, 2010.

Zhu L, Gibson P, Currle DS, Tong Y, Richardson RJ, Bayazitov IT, Poppleton H, Zakharenko S, Ellison DW, Gilbertson RJ. Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature 457:603-7, 2009.

Gilbertson RJ* and Rich JN*. Making a tumor’s bed: the glioblastoma stem cell niche. Nat Rev Cancer 7:733-6, 2007. *co-corresponding authors.

Calabrese C, Poppleton H, Kocak M, Hogg TL, Fuller C, Hamner B, Oh EY, Gaber W, Finklestein D, Allen M, Frank A, Bayazitov IT, Zakharenko SS, Gajjar A, Davidoff A, Gilbertson RJ. A Perivascular niche for brain tumor stem cells. Cancer Cell 11:69-82, 2007.

Taylor MD, Poppleton H, Fuller C, Su X, Liu Y, Jensen P, Magdelano S, Dalton J, Board J, MacDonald T, Rutka J, Guha A, Gajjar A, Curran T, Gilbertson RJ. Radial Glia cells are candidate stem cells of ependymoma. Cancer Cell 8:323-335, 2005.

Last update: November 2011