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Finding Cures. Saving Children.
R. Kiplin Guy, PhD
Member, St. Jude Faculty
Chair, Chemical Biology & Therapeutics
Departments
Chemical Biology & Therapeutics
Contact Information
R. Kiplin Guy, PhD
Chemical Biology & Therapeutics
MS 1000, Room E9050
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: kip.guy@stjude.org
Phone: (901) 595-5714
FAX: (901) 595-5715
Education
PhD - The Scripps Research Institute, La Jolla, California (1996)
Research Interests
- Orphan Diseases: malaria, sleeping sickness, retinoblastoma, ependymoma
- Medicinal chemistry: parallel chemistry, peptidomimetics, hormone antagonists, protease inhibitors
- Cellular biology: chemical target validation, lipid homeostasis, nuclear hormone receptors, protein interactions
- High throughput screening: quantitative assays, data analysis methods
Research Lab
Selected Publications
Teichert A. Arnold A, Otieno S. Oda Y, Augustinaite I, Geistlinger TR, Kriwacki RW, Guy RK, Bikle DD. Differential Binding of Coregulator Motifs to the Vitamin D Receptor: Regulation by Ligand. Biochemistry 48(7), 1454-1461, 2009.
Jones JO, Bolton EC, Huang Y, Feau C, Guy RK, Yamamoto KR, Hann B, Diamond MI. Ligand Independent Androgen Receptor Inhibition in vitro and in vivo. Proc Natl Acad Sci USA 106(17), 7233-8, 2009.
Shahian T, Lee GM, Lazic A, Arnold LA, Velusamy P, Roels CM, Guy RK, Craik CS. Inhibition of a Viral Enzyme by a Small Molecule Dimer Disrupter. Nature Chem Biol 2009 (in press).
Mallari J, Guigemde WA, Guy RK. Antimalarial activity of thiosemicarbazones and purine derived nitriles. Bioorg. Med Chem Lett 2009 (in press).
Hwang JY, Arnold LA, Zhu F, Kosinski A, Mangano TJ, Setola V, Roth BL, Guy RK. Improvement of Pharmacological Properties of Irreversible Thyroid Receptor Coactivator Binding Inhibitors. J Med Chem 2009 (in press).
Guo X, Bandyopadhyay P, Schilling B, Young MM, Fujii N, Aynechi T, Guy RK. Kuntz ID, Gibson BW. Partial Acetylation of Lysine Residues Improves Intra-Protein Cross-linking. Anal Chem 80(4), 951-60, 2008.
Shelat AA, Guy RK. A Road Less Traveled by: Exploring a Decade of Ellman Chemistry. Bioorg Med Chem 17(3), 1089-1093, 2009.
Nicolaou KC, Guy RK. Synthesis of Biologically Active Taxoids. Chemistry and Molecular Aspects of Drug Design and Action 101-108, 2008.
Mallari JP, Shelat AA, Kosinski A, Caffre CR, Connelly M, Zhu F, McKerrow JH, Guy RK. Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB. Bioorg. Med Chem Let 18(9), 2883-85, 2008.
Arnold A, Ranaivo P, Guy RK. Synthesis and Characterization of BODIPY-labeled Colchicine. Bioorg Med Chem Lett 18(22), 5867-5870, 2008.
Feau C, Arnold LA, Kosinski A. Guy RK. A high throughput Ligand Competition Binding Assay for the Androgen Receptor and other Nuclear Receptors. J Biomol Screen 14(1), 43-48, 2008.
Last update: May 2009
