Michael Kastan, MD, PhD

Michael B. Kastan, MD, PhD

Member, St. Jude Faculty
Cancer Center Director
Director, Molecular Therapeutics Division

Departments

Oncology

Divisions

Molecular Therapeutics

Contact Information

Michael Kastan, MD, PhD
Oncology
MS 310, Room D5048
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: michael.kastan@stjude.org
Phone: (901) 595-3968
FAX: (901) 595-3966

Education

MD - Washington University School of Medicine
PhD - Washington University School of Medicine


Research Interests

  • Radiation biology
  • DNA damage and repair
  • Tumor suppressor genes
  • Determinants of chemosensitivity and radiosensitivity
  • Ataxia-telangiectasia
  • Causes of cancer - genetic predisposition and environmental contributions

Selected Publications

Ofir-Rosenfeld Y, Boggs K, Michael D, Kastan MB, Oren M. Mdm2 regulates p53 mRNA Translation through Inhibitory Interactions with Ribosomal Protein L26. Molecular Cell 32: 180-189, 2008.

Rainey MD, Charlton ME, Stanton RV, Kastan MB. Transient Inhibition of ATM Kinase Is Sufficient to Enhance Cellular Sensitivity to Ionizing Radiation. Cancer Res 68: 7466-7474, 2008.

Chandhasin C, Ducu RI, Berkovich E, Kastan MB, Marriott SJ. Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response. J Virol 82: 6952-6961, 2008.

Kastan MB. 2007 G.H.A. Clowes Memorial Award Lecture, DNA Damage Responses: Mechanisms and Roles in Human Disease. Mol Cancer Res 6: 517-524, 2008.

Berkovich E, Monnat, RJ, Kastan MB. Assessment of Protein Dynamics and DNA Repair Following Generation of DNA Double Strand Breaks at Defined Genomic Sites. Nature Protocols 3: 915-922, 2008.

Tang X, Hui Z, Cui X, Garg R, Kastan MB, Xu B. A novel ATM-dependent pathway regulates Protein Phosphatase 1 in response to DNA damage. Mol Cell Biol 28: 2559-2566, 2008.

Maclean KH, Dorsey FC, Cleveland JL, Kastan MB. Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. Journal of Clinical Investigation 118: 79-88, 2008.

Loehberg CR, Thompson T, Kastan MB, Maclean KH, Edwards DG, Kittrell FS, Medina D, Conneely OM, O’Malley BW. Ataxia Telangiectasia-Mutated and p53 are Potential Mediators of Chloroquine-Induced Resistance to Mammary Carcinogenesis. Cancer Research 67: 12026-12033, 2007.

Maclean KH, Kastan MB, Cleveland JL. Atm Deficiency Affects both Apoptosis and Proliferation to Augment myc-Induced Lymphomagenesis. Molecular Cancer Research 5: 705-711, 2007.

Kastan, MB. Our Cells Get Stressed Too! Implications for Human Disease. Blood Cells, Molecules & Diseases 39: 148-50, 2007.

Kastan MB, Berkovich E. p53: A Two-Faced Cancer Gene. Nature Cell Biology 9: 489-491, 2007.

Kastan MB. Wild-Type P53: Tumors Can’t Stand It. Cell 128:837-840, 2007.

Berkovich E, Monnat RJ, Kastan MB. Roles of ATM and NBS1 in chromatin structure modulation and double strand break repair. Nature Cell Biology 9: 683-690, 2007.

Schneider JG, Finck BN, Ren J, Standley KN, Takagi M, Maclean KH, Bernal-Mizrachi C, Muslin AJ, Kastan MB, Semenkovich CF. ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Cell Metabolism 4: 377-389, 2006.

Sandlund JT, Kastan MB, Kennedy W, Behm F, Entrekin RE, Pui C-H, Kalwinsky DT, Raimondi SC. A subtle t(3;8) results in plausible juxtaposition of MYC and BCL6 in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia. Cancer Genetics and Cytogenetics 168: 69-72, 2006.

Bekker-Jensen S, Lukas C, Kitagawa R, Melander F, Kastan MB, Bartek J, Lukas J. Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J. Cell Biology 173(2): 195-206, 2006.

Morales M, Theunissen J-W, Kim C, Kitagawa R, Kastan MB, Petrini, JH. The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency:  Implications for the Mre11 complex as a DNA damage sensor. Genes & Development 19(24): 3043-54, 2005.

Takagi M, Abasalon M, McLure KG, Kastan MB. Regulation of p53 Translation and Induction after DNA Damage by Ribosomal Protein L26 and Nucleolin. Cell 123: 49-63, 2005.

Bartkova J, Bakkenist C, Rajpert-De Meyts E, Skakkebaek N, Sehested M, Lukas J, Kastan MB, Bartek J.  ATM Activation in Normal Human Tissues and Testicular Cancer.  Cell Cycle 4: 838-845, 2005.

Bakkenist CJ, Kastan MB. Initiating Cellular Stress Responses. Cell 118: 9-17, 2004.

McLure KG, Takagi M, Kastan MB. Small molecule modulation of p53 DNA binding specificity and function. Mol Cell Biol 24: 9958-9967, 2004.

Kitagawa R, Bakkenist CJ, McKinnon PJ, Kastan MB. Phosphorylation of SMC1 is a Critical Downstream Event in the ATM-NBS1-BRCA1 Pathway. Genes and Development 18: 1423-1438, 2004.

Bakkenist CJ, Kastan MB. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421: 499-506, 2003.

Xu B, O’Donnell AH, Kim S-T, Kastan MB. Phosphorylation of Serine 1387 is Specifically Required for the Atm-Mediated S-phase Checkpoint After Ionizing Irradiation. Cancer Res 62: 4588-4591, 2002.

Taniguchi T, Garcia-Higuera I, Xu B, Andreassen PR, Gregory RC, Kim S-T, Lane WS, Kastan MB, D’Andrea AD. Convergence of the Fanconi Anemia and Ataxia Telangiectasia Signaling Pathways. Cell 109:459-472, 2002.

Kim S-T, Xu B, Kastan MB. Involvement of the Cohesin Protein, Smc1, in Atm-Dependent and Independent Responses to DNA Damage. Genes & Development 16: 560-570, 2002.

Xu B, Kim S-T, Lim D-S, Kastan MB. Two Molecularly Distinct G2/M Checkpoints Are Induced by Ionizing Irradiation. Mol Cell Biol 22: 1049-1059, 2002.

Xu B, Kim S-T, Kastan MB. Involvement of Brca1 in S-phase and G2-Phase Checkpoints after ionizing irradiation. Mol Cell Biol 21: 3445-3450, 2001.

Kastan MB, Lim D-S. The Many Substrates and Functions of ATM. Nature Reviews Molecular Cell Biology 1:179-186, 2000.

Yang D, Kastan MB. Participation of ATM in Insulin Signalling through Phosphorylation of eIF-4E Binding Protein 1 (4E-BP1). Nature Cell Biology 2:893-898, 2000.

Lim D-S, Kim S-T, Xu B, Maser RS, Lin J, Petrini JHJ, Kastan MB. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature 404:613-617, 2000.

Kim S-T, Lim D-S, Canman CE, Kastan MB. Substrate specificities and identification of putative substrates of ATM kinase family members. J Biol Chem 274: 37538-37543, 1999.

Canman CE, Lim D-S, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281:1677-1679, 1998.

Canman CE, Gilmer T, Coutts S, Kastan MB. Growth factor modulation of p53-mediated growth arrest vs. apoptosis. Genes & Dev 9:600-611, 1995.

Hartwell LH, Kastan MB. Cell cycle control and cancer. Science 266:1821-1828, 1994.

Canman CE, Wolff AC, Chen C-Y, Fornace AJ Jr., Kastan MB. The p53-dependent cell cycle checkpoint pathway and ataxia-telangiectasia. Cancer Research 54:5054-5058, 1994.

Nelson WG, Kastan MB. DNA strand breaks: the DNA template alteration that triggers p53-dependent DNA damage response pathways. Mol Cell Biol 14:1815-1823, 1994.

Kastan MB, Zhan Q, El-Deiry WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B, Fornace AJ Jr. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia telangiectasia. Cell 71:587-597, 1992.

Last update: June 2009

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