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Finding Cures. Saving Children.
Katsumi Kitagawa, PhD
Assistant Member, St. Jude Faculty
Departments
Molecular Pharmacology
Contact Information
Katsumi Kitagawa, PhD
Molecular Pharmacology
MS 230, Room D-3007C
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Research Interests
- Molecular mechanisms of high-fidelity chromosome transmission
- Yeast Project
- Human Project
- Laboratory Members
Selected Publications
Kitagawa K*, Niikura Y Caspase-Independent Mitotic Death (CIMD). Cell Cycle 2008 (in press).
Ohkuni K, Abdulle R, Tong AHY, Boone C, Kitagawa K*. Ybp2 Associates with the central kinetochore of Saccharomyces cerevisiae and mediates proper mitotic progression. PloS ONE 2008 (in press).
Niikura Y, Dixit A, Scott R, Perkins G, Kitagawa K* BUB1 mediation of caspase-independent mitotic death determines cell fate. J Cell Biol 178:283-96, 2007.
Scaglione KM, Bansal PK, Deffenbaugh AE, Kiss A, Moore JM, Korolev S, Cocklin R, Goebl M, Kitagawa K, Skowyra D. SCF E3 -mediated autoubiquitination negatively regulates activity of the Cdc34 E2 but plays a nonessential role in the catalytic cycle in vitro and in vivo. Mol Cell Biol 27:5860-70, 2007.
Kondo-Okamoto N, Ohkuni K, Kitagawa K, McCaffery JM, Shaw JM, Okamoto K. The novel F-box protein Mfb1p regulates mitochondrial connectivity and exhibits asymmetric localization in yeast. Mol Biol Cell 17:3756-67, 2006.
Niikura Y, Ohta S, Vandenbeldt KJ, Abdulle R, McEwen BF, Kitagawa K* 17-AAG, an Hsp90 inhibitor, causes kinetochore defects: a novel mechanism by which 17-AAG inhibits cell proliferation. Oncogene 25:4133-46, 2006.
Bansal PK, Abdulle R, Kitagawa K.* Sgt1 associates with molecular chaperones: an initial step of assembly of the core kinetochore complex. Mol Cell Biol 24:8069-79, 2004.
Steensgaard P, Garre M, Muradore I, Transidico P, Nigg EA, Kitagawa K, Earnshaw WC, Faretta M, Musacchio A. Sgt1 is required for human kinetochore assembly. EMBO Rep 5:626-31, 2004.
Niikura Y, Kitagawa K.* Identification of a novel splice variant: Human SGT1B (SUGT1B). DNA Sequence14:436-41, 2003.
Kitagawa K,* Abdulle R, Bansal PK, Cagney G, Fields S, Hieter P. Requirement of Skp1-Bub1 interaction for kinetochore-mediated activation of the spindle checkpoint. Mol Cell 11:1201-13, 2003.
Nowotny M, Spiechowicz M, Jastrzebska B, Filiped A, Kitagawa K, Kuznicki J. Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins. J Biol Chem 278:26923-28, 2003.
Kitagawa K,* Abdulle R. In vivo site-directed mutagenesis of yeast plasmids by using a three-fragment homologous recombination system. Biotechniques 33:288, 290, 292 passim, 2002.
Kitagawa K.* Kinetochore: structure, function and evolution. The Encyclopedia of the Human Genome A1237, 2002.
Schadick KH, Fourcade M, Boumenot P, Seitz JJ, Morrell JL, Chang L, Gould KL, partridge JF, Allshire RC, Kitagawa K, Hieter P, Hoffman CS. Schizosaccharomyces pombe Git7p, a member of the Saccharomyces cerevisiae Sgt1p family, is required for glucose/camp signaling, cell wall integrity, and septation. Eukaryotic Cell 1:558-67, 2002.
Dubacq C, Guerois R, Courbeyrette R, Kitagawa K, Mann C. Sgt1p contributes to camp pathway activity and physically interacts with the adenylyl cyclase Cyr1p/Cdc35p in budding yeast. Eukaryotic Cell 1:568-82, 2002.
Azevedo C, Sadanandom A, Kitagawa K, Freialdenhoven A, Shirasu K, Schulze-Lefert P. The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance. Science 295-2073-76, 2002.
Kitagawa K,* Hieter P. Evolutionary conservation between budding yeast and human kinetochores. Nature Reviews Mol Cell Biol 2:678-87, 2001.
Kitagawa K, Skowyra D, Elledge SJ, Harper JW, Hieter P. SGT1 encodes an essential component of theyeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. Mol Cell 4:21-33, 1999.
Iwahara J, Kigawa T, Kitagawa K, Masumoto H, Okazaki T, Yokoyama S. A helix-turn-helix structure unit in human centromere protein B (CENP-B). EMBO J 17:827-37, 1998.
Yoda K, Nakamura T, Masumoto H, Suzuki N, Kitagawa K, Nakano M, Shinjo A, Okazaki T. Centromere protein B of African green monkey cells: gene structure, cellular expression, and centromeric localization. Mol Cell Biol 16:5169-77, 1996.
Bassett DE Jr, Basrai MA, Connelly C, Hyland KM, Kitagawa K, Mayer ML, Morrow DM, Page AM, Restro VA, Skibbens RV, Hieter P. Exploiting the complete yeast genome sequence. Curr Opin Genet Dev 6:763-66, 1996.
Kitagawa K, Masumoto H, Ikeda M, Okazaki T. Analysis of protein-DNA and protein-protein interactions of centromere protein B (CENP-B) and properties of the DNA-CENP-B complex in the cell cycle. Mol Cell Biol 15:1602-12, 1995.
Seki N, Saito T, Kitagawa K, Masumoto H, Okazaki T, Hori T. Mapping of the human centromere protein B (CENPB) to chromosome 20p13 by fluorescence in situ hybridization. Genomics 24:187-8, 1994.
Yoda K, Kitagawa K, Masumoto H, Muro Y, Okazaki T. A human centromere protein, CENP-B, has a DNA binding domain containing four potential a helices at the NH2 terminus, which is separable from dimerizing activity. J Cell Biol 119:1413-27, 1992.
* corresponding author
Last update: April 2008
