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Finding Cures. Saving Children.
Risa Kitagawa, PhD
Assistant Member, St. Jude Faculty
Departments
Molecular Pharmacology
Contact Information
Risa Kitagawa, PhD
Molecular Pharmacology
MS 230, Room D3022B
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: risa.kitagawa@stjude.org
Phone: (901) 595-4058
FAX: (901) 595-4290
Research Interests
- Mechanism of eukaryotic cell cycle regulation
- DNA damage response in eukaryotic cells
Characterization of CeMAD1–deletion suppressors
Characterization of the molecular link between the DNA damage checkpoint and mitotic arrest
Elucidation of the Molecular Mechanisms that Link PTEN Function to the Spindle Assembly Checkpoint
Genome stability in germ cells
Identification and Characterization of Novel Components of the Spindle Assembly Checkpoint
The impaired SAC activity and sensitivity to antimitotic agents
Selected Publications
Watanabe S, Yamamoto TG, Kitagawa R. Spindle assembly checkpoint gene mdf-1 regulates germ cell proliferation in response to nutrition signals in C. elegans. EMBOJ 2008 (in press).
Tarailo M, Kitagawa R, Rose AM. Suppressors of spindle checkpoint defect (such) mutants identify new mdf-1/MAD1 interactors in Caenorhabditis elegans. Genetics April:175(4): 1665-79, 2007.
Bekker-Jensen S, Lukas C, Kitagawa R, Melander F, Kastan MB, Bartek J, Lukas J. Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaksJ Cell Biol Apr 24;173(2):195-206, 2006.
Kitagawa R, Kastan MB. The ATM-Dependent DNA Damage Signaling Pathway. Cold Spring Harb Symp Quant Biol 70:99-109, 2005. Review.
Morales M, Theunissen JW, Kim CF, Kitagawa R, Kastan MB, Petrini JH. The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: Implications for the Mre11 complex as a DNA damage sensor. Genes Dev Dec 15;19(24):3043-54, 2005.
Kitagawa R, Bakkenist CJ, McKinnon PJ, Kastan MB. Phosphorylation of SMC1 is the critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev 18:1423-1438, 2004.
Kitagawa R, Law E, Tang L, Rose AM. The Cdc20 homolog, FZY-1 and its interacting protein, IFY-1 are required for proper chromosome segregation in Caenorhabditis elegans. Curr Biol 12:2118-2123, 2003.
Ozaki T, Kumaki Y, Kitagawa R, Ogawa T. Anomalous DnaA protein binding to the regulatory region of the Escherichia coli aldA gene. Microbiology 147:153-159, 2001.
Furuta T, Tuck S, Kirchner J, Koch B, Auty R, Kitagawa R, Rose AM, Greenstein D. EMB-30: an APC4 homologue required for metaphase-to-anaphase transitions during meiosis and mitosis in Caenorhabditis elegans. Mol Biol Cell 11:1401-1419, 2000.
Kitagawa R, Rose AM. Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans. Nat Cell Biol 1:514-521, 1999.
Kitagawa R, Ozaki T, Moriya S, Ogawa T. Negative control of replication initiation by a novel chromosomal locus exhibiting exceptional affinity for Escherichia coli DnaA protein. Genes Dev 12:3032-3043, 1998.
Kitagawa R, Mitsuki H, Okazaki T, Ogawa T. A novel DnaA protein-binding site at 94.7 min on the Escherichia coli chromosome. Mol Microbiol 19:1137-1147, 1996.
Last updated: March 2008
