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Solid Tumor : Rhabdomyosarcoma
Rhabdomyosarcoma or a similar tumor called ectomesenchymoma is a type of cancer that occurs in the soft tissues in children and adolescents, and affects a few hundred children in the United States each year. Currently, more than 70% of children with localized rhabdomyosarcoma can be cured of their disease with treatment that includes surgical removal of tumor (when possible), anti-cancer drugs (chemotherapy), and high energy x-rays (radiation therapy). Children with rhabdomyosarcoma that has spread to other parts of the body from where it started have a poor prognosis. Only about 25% of these patients can be cured.
The standard drugs used for rhabdomyosarcoma are vincristine, actinomycin D and cyclophosphamide, and are often called VAC therapy. Past studies have been done using higher doses of cyclophosphamide but that has not increased the treatment success for high risk patients. Recent studies have added other drugs to standard VAC therapy while giving the drugs more often. The additional chemotherapy drugs are ifosfamide, etoposide, doxorubicin and irinotecan. The combination of the standard VAC therapy and these additional drugs may lead to more cures in high-risk patients. This study is designed to see if adding two additional drugs (Cixutumumab and Temozolomide) to multi-drug chemotherapy is well tolerated.
For the current eligibility status of this clinical study, referring physicians must contact St. Jude Children's Research Hospital at 1-866-2ST-JUDE (1-866-278-5833).
Sheri L. Spunt, MD
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105 USA
Voice: 1-888-226-4343 or 901-595-4055
Referring or consulting physicians only: firstname.lastname@example.org
For all other inquiries about St. Jude Children's Research Hospital studies: email@example.com
The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.