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Annually, there are an estimated 176,000 newly diagnosed cases of childhood cancer worldwide in children 0-14 years of age. Approximately 84% of new cases occur in low- and middle income countries. Despite dramatic improvements in overall survival rates for children with cancer, an estimated 60% do not have access to adequate diagnosis and care worldwide. More than 50% of children diagnosed with cancer die, and the majority of those deaths occur in resource-poor settings. To address this gap, St. Jude partners with institutions in low- and middle-income countries to promote sustainable improvements in pediatric cancer care.