Hematology Research Publications



2009

Soulas C, Donahue RE, Dunbar CE, Persons DA, Alvarez X, Williams KC. Genetically modified CD34+ hematopoietic stem cells contribute to turnover of brain perivascular macrophages in long-term repopulated primates. Am J Pathol May;174(5):1808-17, 2009. Epub 2009 Apr 6.

Hanawa H, Yamamoto M, Zhao H, Shimada T, Persons DA. Optimized lentiviral vector design improves titer and transgene expression of vectors containing the chicken beta-globin locus HS4 insulator element. Mol Ther Apr;17(4):667-74, 2009. Epub 2009 Feb 17.

Zhao H, Pestina TI, Nasimuzzaman M, Mehta P, Hargrove PW, Persons DA. Amelioration of murine {beta}-thalassemia through drug selection of hematopoietic stem cells transduced with a lentiviral vector encoding both {gamma}-globin and the MGMT drug resistance gene. Blood Apr 13, 2009. [Epub ahead of print]

Kim YJ, Kim YS, Larochelle A, Renaud G, Wolfsberg TG, Adler R, Donahue RE, Hematti P, Hong BK, Roayaei J, Akagi K, Riberdy JM, Nienhuis AW, Dunbar CE, Persons DA. Sustained high level polyclonal hematopoietic marking and transgene expression four years following autologous transplantation of rhesus macaques with SIV lentiviral vector transduced CD34+ cells. Blood Apr 1, 2009. [Epub ahead of print]

Pestina TI, Hargrove PW, Jay D, Gray JT, Boyd KM, Persons DA. Correction of murine sickle cell disease using gamma-globin lentiviral vectors to mediate high-level expression of fetal hemoglobin. Mol Ther  Feb;17(2):245-52, 2009. Epub 2008 Dec 2.

Lebensburger J, Persons DA. Progress toward safe and effective gene therapy for beta-thalassemia and sickle cell disease. Curr Opin Drug Discov Devel Mar;11(2):225-32, 2008. Review.

Hassell K, Pace B, Wang W, Kulkarni R, Luban N, Johnson CS, Eckman J, Lane P, Woods WG. Sickle cell disease summit: from clinical and research disparity to action. Am J Hematol Jan;84(1):39-45, 2009.


2008

Lebensburger J, Esbenshade A., Blakely M, Hankins J, Wang W. Biloma and Pneumobilia in Sickle Cell Disease. Pediatr Blood Cancer Aug:51(2):288-1290, 2008.

Basran R, Reiss U, Luo H, Ware RE, Chui D. β-thalassemia intermedia due to compound heterozygosity for two β-globin gene promoter mutations, including a novel TATA box deletion. Pediatr Blood Cancer 50:363- 366, 2008.

Hargrove PW, Kepes S, Hanawa H, Obenauer J, Pei D, Cheng C, Gray, JT, Neale G, Persons DA. Globin lentiviral vector insertions can perturb the expression of endogenous genes in β-thalassemic hematopoietic cells. Mol Ther advance online publication, January 15, 2008; doi:10.1038/sj.mt.6300394

Hankins JS, Fortner G, McCarville MB, Smeltzer M, Wang WC, Li C-S, Ware RE. The natural history of conditional transcranial doppler flow velocities in children with sickle cell anemia. Br J Haematol 2008 (in press).

Hankins JS, Helton KJ, McCarville BM, Li CS, Wang WC, Ware RE. Preservation of spleen and brain function in children with sickle cell anemia treated with hydroxyurea.  Pediatr Blood Cancer 50:293-297, 2008.

Hankins J, Fortner G, McCarville B, Wang W, Smeltzer M, Ware R. Conditional Transcranial Doppler Ultrasound Velocities: Risk of Conversion to Abnormal in Children with Sickle Cell Anemia. Br J Haematol Jul;142(1):94-9, 2008.

Hankins J, Wynn L, Brugnara C, Hillery S, Li CS, Wang W.  Phase I Study of Combination Treatment with Hydroxyurea and Magnesium Pidolate in Children with Sickle Cell Anemia. Br J Haematol Jan;140(1):80-5. Epub 2007 Nov 7, 2008.

Hargrove PW, Kepes S, Hanawa H, Obenauer J, Pei D, Cheng C, Gray, JT, Neale G, Persons DA. Globin lentiviral vector insertions can perturb the expression of endogenous genes in β-thalassemic hematopoietic cells. Mol Ther advance online publication, January 15, 2008; doi:10.1038/sj.mt.6300394

Sanchez GL, Reiss UM, de Alarcon PA.  Risk of thrombosis with anomalies of the inferior vena cava and factor V Leiden. Case report and review.  Pediatr Blood Cancer 50:731, 2008.

Shankar SM, Arbogast PG, Mitchel E, Ding H, Wang WC, Griffin MR. Impact of access to comprehensive care on utilization of healthcare services among children with sickle cell disease. Pediatr Blood  Cancer 50:66-71, 2008

Ryu BY, Evans-Galea MV, Gray JT, Persons DA, Bodine DM, Nienhuis AW. An experimental system for the evaluation of retroviral vector design to diminish the risk for proto-oncogene activation. Blood 111:1866-1875, 2008.

Wang W.  Developing a comprehensive transcranial Doppler screening program for children with sickle cell anemia. Pediatr Blood Cancer 2008 (in press).

 

2007

Evans-Galea MV, Wielgosz MM, Hanawa H, Srivastava DK, Nienhuis AW. Suppression of clonal dominance in cultured human lymphoid cells by addition of the cHS4 insulator to a lentiviral vector. Mol Ther 15:801-9, 2007.

Fung EB, Harmatz P, Milet M, Ballas SK, DeCastro, L, Hagar W, Hilliard L, Owen W, Olivieri N, Smith-Whitley K, Darbari D, Wang W, Vichinsky E, and the Multi-Center Study of Iron Overload Research Group. Morbidity and mortality in chronically transfused subjects with thalassemia and sickle cell disease: a report from the multi-center study of iron overload. Am J Hematol 82:255-265, 2007.

 Harrod VL, Howard TA, Zimmerman SA, Dertinger SD, Ware RE. Quantitative analysis of Howell-Jolly bodies in children with sickle cell disease. Exp Hematol 35:179-183, 2007

.Halasa NB, Shankar SM, Talbot TR, Arbogast PG, Mitchel EF, Wang WC, Schaffner W, Craig AS, Griffin MR.  Incidence of invasive Pneumococcal disease in individuals with sickle cell disease before and after the introduction of the Pneumococcal conjugate vaccine. Clin Infect Dis 44:1428-1433, 2007.

 Hankins J, Hinds P, Day S, Carroll Y, Naidu P, Li CS, Wang W. Therapeutic Preference and Decision-Making among Patients with Severe Sickle Cell Anemia and Their Families. Pediatric Blood and Cancer Jun 15;48(7):705-10, 2007.

Hankins J, Wynn L, Brugnara C, Hillery C, Li C-S, Wang W. Phase I study of  Magnesium pidolate in combination with hydroxyurea for children with sickle cell anemia. Brit J Haematol 140:80-85, 2007.

 Hu XJ, Schroeder RJ, Wang WC, Boyett JM. Pseudoscore based estimation from biased observations. Stat Med 26:2839-2852, 2007.

 Miller ML, Gao G, Pestina T, Persons D, Tuomanen E. Hypersusceptibility to invasive pneumococcal infection in experimental sickle cell disease involves PAF receptor. J Infect Dis Feb 15;195:581-4. Epub 2007 Jan 8, 2007.

Reiss UM, Bensimhon P, Zimmerman SA, Ware RE. Hydroxyurea therapy for management of secondary erythrocytosis in cyanotic congenital heart disease. Am J Hematol 82:740-743, 2007.

Ryu BY, Evans-Galea MV, Gray JT, Bodine DM, Persons DA, Nienhuis AW. An experimental system for the evaluation of retroviral vector design to diminish the risk for proto-oncogene activation.enhancer/promoter. Blood Nov 8, 2007; [Epub ahead of print].

Ryu B, Persons DA, Evans-Galea M, Gray JT, and Nienhuis AW. The influence of a chromatin insulator on interactions between globin regulatory elements and cellular promoters in erythroid cells. Blood Cells Mol Dis Jun 28, 2007; [Epub ahead of print]

Ryu BY, Evans-Galea MV, Gray JT, Persons DA, Bodine DM, Nienhuis AW. A chromatin insulator blocks interactions between globin regulatory elements and cellular promoters in erythroid cells. Blood Cells, Mol Dis 39:221-8, 2007.

Will E, Bailey J, Schuesler T, Modlich U, Balcik B, Burzynski B, Witte D, Layh-Schmitt G, Rudolph C, Schlegelberger B, von Kalle C, Baum C, Sorrentino BP et al. Importance of murine study design for testing toxicity of retroviral vectors in support of phase I trials. Mol Ther 15:782-91, 2007.

Wilson MW, Hoehn ME, Haik BG, Rieman M, Reiss U.  Low-dose cyclophosphamide and interferon alfa 2a for the treatment of capillary hemangioma of the orbit. Ophthalmology 114:1007-1011, 2007.

Zimmerman SA, Schultz WH, Burgett S, Mortier NA, Ware RE. Hydroxyurea therapy lowers transcranial doppler flow velocities in children with sickle cell anemia. Blood 110 (3): 1043-1047, 2007.

 

2006

Hankins J, Hinds P, Day S, Carroll Y, Li C-S, Garvie P, Wang W.  Therapy preference and decision-making among patients with severe sickle cell anemia and their families. Pediatr Blood Cancer 48:705-710, 2006.

Husain SM, Shou Y, Sorrentino BP, Handgretinger R. Isolation, molecular cloning and in vitro expression of rhesus monkey (Macaca mulatta) prominin-1.s1 complementary DNA encoding a potential hematopoietic stem cell antigen. Tissue Antigens 68:317-24, 2006.

Hulbert ML, Scothorn DJ, Panepinto JA, Scott JP, Buchanan GR, Sarnaik S, Fallon R, Chu J-Y, Wang W, Casella JF, Resar L, Berman B, Adamkiewicz T, Hsu LL, Smith-Whitley K, Mahoney D, Woods G, Watanabe M, DeBaun M. Exchange blood transfusion for first overt stroke is associated with a lower risk of subsequent stroke than simple transfusion: a retrospective cohort of 137 children with sickle cell anemia. J Pediatr 149:710-712, 2006.

Leggas M, Panetta JC, Zhuang Y, Schuetz JD, Johnston B, Bai F, Sorrentino B, Zhou S, Houghton PJ, Stewart CF. Gefitinib modulates the function of multiple ATP-binding cassette transporters in vivo. Cancer Research 66:4802-7, 2006.

Luo HY, Heeny M, Wang WC, Eung SH, Ware RE, Steinberg MH, Chui DHK. Hemoglobinopathies mimicking Hb S/β-thalassemia: Hb SS with α-thalassemia and Hb S/Volga. Am J Hematol 81: 361-365, 2006.

Reiss UM, de Alarcon PA, Shafer FE.  Acanthocytosis.  www.emedicine.com, 2006.

Seggewiss R, Pittaluga S, Adler RL, Guenaga FJ, Ferguson C, Pilz IH, Ryu B, Sorrentino BP, Young WS 3rd, Donahue RE, von Kalle C, Nienhuis AW, Dunbar CE. Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque. Blood 107:3865-7, 2006.

Shou Y, Ma Z, Lu T, Sorrentino BP. Unique risk factors for insertional mutagenesis in a mouse model of XSCID gene therapy. Proc Natl Acad Sci USA 103:11730-5, 2006.

Tadjali M, Zhou S, Rehg J, Sorrentino BP. Prospective isolation of murine hematopoietic stem cells by expression of an Abcg2/GFP allele. Stem Cells 24:1556-63, 2006.

Thrasher AJ, Gaspar HB, Baum C, Modlich U, Schambach A, Candotti F, Otsu M, Sorrentino B, Scobie L, et al. Gene therapy, X-SCID transgene leukaemogenicity. Nature 443: 7109 (letter to editor), 2006.

Zhang J, Randall MS, Loyd MR, Li W, Schweers RL, Persons DA, Rehg JE, Noguchi CT, Ihle JN, Ney PA. Role of erythropoietin receptor signaling in Friend virus-induced erythroblastosis and polycythemia. Blood 107:73-8, 2006.

Zong Y, Zhou S, Sorrentino BP. Reply to Rumpold et al. Leukemia 20:144-45, 2006.

Zong Y, Zhou S, Fatima S, Sorrentino BP. Expression of mouse Abcg2 mRNA during hematopoiesis is regulated by alternative use of multiple leader exons and promoters. J Biol Chem 281:29625-32, 2006.

 

2005

Ahn H, Li C-S, Wang W. Sickle cell hepatopathy: clinical presentation, treatment, and outcome in pediatric and adult patients. Pediatr Blood Cancer 45:184-190, 2005.

Andeansky S, Liu H, Turner S, McCullers JA, Lang R, Rutschman R, Doherty PC, Murray PJ, Nienhuis AW, Strom TS. WASP-mice exhibit defective immune responses to influenza A virus, Streptococcus pneumoniae, and Mycobacterium bovis BCG. Exp Hematol 33:443-51, 2005.

Aygun B, Lanzkowsky P. Book Chapter: Disorders of platelets. Manual of Pediatric Hematology and Oncology 250-294, 2005.

Aygun B, Lanzkowsky P. Book Chapter: Lymphadenopathy and splenomegaly. Manual of Pediatric Hematology and Oncology 363-370, 2005.

Aygun B, Lanzkowsky P. Book Chapter: Malignant bone tumors. Manual of Pediatric Hematology and Oncology 585-603, 2005.

Aygun B, Lanzkowsky P. Book Chapter: Supportive care and management of oncologic emergencies. Manual of Pediatric Hematology and Oncology 695-748, 2005.

Dominici M, Merhdad T, KepesS, Allay ER, Boyd K, Ney PA, Horwitz E, Persons DA. Transgenic mice with pancellular enhanced green fluorescent protein expression in primitive hematopoietic cells and all blood cell progeny. Genesis 42:17-22, 2005.

Hanawa H, Persons DA, Nienhuis AW. Mobilization and mechanism of transcription of integrated self-inactivating (SIN) lentiviral vectors. J Virol 79:8410-21, 2005.

Hankins JS, Ware RE, Rogers ZR, Wynn LW, Lane PA, Scott JP, Wang WC. Long-term hydroxyurea therapy for infants with sickle cell anemia: the HUSOFT extension study. Blood 106:2269-2275, 2005.

Hankins JS, Jeng M, Harris S, Li SC; Liu T, Wang W. Chronic Transfusion for Children with Sickle Cell Disease and Recurrent Acute Chest Syndrome. J Pediatr Hematol Oncol 27:158–161, 2005.

Garcia-Aria MB, Rodriguez-Galindo C, Hoffer FA, Wang WC. Pyogenic hepatic abscess after percutaneous liver biopsy in a patient with sickle cell disease. J Pediatr Hematol Oncol 27:103-105, 2005.

Inaba H, Geiger TL, Lasater OE, Wang WC. A case of hemoglobin SC disease with cold agglutinin-induced hemolysis. Amer J Hematol 78:37-40, 2005.

Jeng MR, Naidu PE, Rieman MD, Rodriguez-Galindo C, Nottage KA, Thornton DT, Li CS, Wang WC. Granulocyte-macrophage colony stimulating factor and immunosuppression in the treatment of pediatric acquired severe aplastic anemia. Pediatr Blood Cancer 45:170-175, 2005.

McGaha TL, Sorrentino B, Ravetch JV. Restoration of tolerance in lupus by targeted inhibitory receptor expression. Science 307: 590-3. 2005.

Ozvegy-Laczka C, Varady G, Koblos G, Ujhelly O, Cervenak J, Schuetz JD, Sorrentino BP, Koomen GJ, Varadi A, Nemet K, Sarkadi B. Function-dependent Conformational Changes of the ABCG2 Multidrug Transporter Modify its Interaction with a Monoclonal Antibody on the Cell Surface. J Biol Chem 280: 4219-27. 2005.

Shankar SM, Argogast AE, Mitchel E, Cooper WO, Wang WC, Griffin MR. Medical care utilization and mortality in sickle cell disease: a population-based study.  Am J Hematol 80:262-270, 2005.

Stepanova L, Sorrentino BP. A limited role for p16Ink4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress. Blood 106:827-32, 2005.

Wang WC, Morales KH, Scher CD, Styles L, Olivieri N, Adams R, Brambilla D. Effect of chronic transfusion on growth in children with sickle cell anemia: results of the STOP trial. J Pediatr 147:244-247, 2005

.Woodard P, Helton KJ, Khan RB, Hale GA, Phipps S, Wang W, Handgretinger R, Cunningham JM. Brain parenchymal damage after haematopoietic stem cell transplantation for severe sickle cell disease. Br J Haematol 129:550-552, 2005.

Zhou S, Yong Y, Ney PA, Nair G, Stewart CF, Sorrentino BP. Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels. Blood 105: 2571-6. 2005.

Zong Y, Zhou S, Sorrentino BP. Loss of P-glycoprotein expression in hematopoietic stem cells does not improve responses to imantinib in a murine model of chronic myelogenous leukemia. Leukemia 19:1590-6, 2005.