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Associated Hematology Studies, Supportive Studies: Genetics
Iron overload, defined as too much iron in the body, may develop when someone has many blood transfusions, or because of inherited defects . Iron can build up in several organs in the body, such as the heart, liver, endocrine glands (pancreas, thyroid, etc.), and spleen. Too much iron can damage organs and may even cause death. Therefore, iron overload needs to be appropriately watched and treated to avoid unnecessary disease or death. Iron builds up differently in different people, and in different organs of the body. Some people build up iron faster than others, even when receiving the same number of blood transfusions.
This study will investigate whether genes have any influence on how much iron accumulates in the body, especially in the liver, heart, and other abdominal organs. We will also investigate if certain genes influence how iron exits the body.The duration of the study will be for six years.
Jane Hankins, MD, MS
The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.