Current Nutrition Research

Affects of Dehydration on Pediatric Patients with Sickle Cell Anemia
The relationship between dehydration and sickle cell crisis is an important one that needs to be addressed more in depth. Studies have proven proper hydration can aid in the prevention and treatment of sickle cell pain crisis. The purpose of this study is to conduct a descriptive analysis to identify if hydration status can be measured by BIA in children with SCA and determine if patients will be able to keep a food log to assess fluid intake. The main objective will be to collect information to determine if further research is warranted.

 

Obesity and Acute Lymphocytic Leukemia
Many factors influence development of overweight and obesity in pediatric ALL survivors. Factors known to be associated with increased weight gain include age at diagnosis, being female, those overweight or obese at baseline, receiving cranial radiation therapy, exposure to corticosteroids, and Black or Hispanic race. To date no studies have evaluated the impact of diet on the incidence of obesity in pediatric ALL survivors. Therefore, the aim of our study is to evaluate the relationship between caloric and macronutrient intake on the incidence of obesity in survivors of pediatric ALL.

 

Nutrition Knowledge of the Pediatric Cancer Survivor
The importance of understanding nutrition cannot be underestimated, especially in the pediatric cancer population. It is so important for those children to receive good nutrition. Based on the findings of the pilot study done with childhood cancer survivors, this population feels a greater understanding of nutrition may lead to a decreased incidence of developing nutrition related cancers. It has been identified as a need and hopefully the knowledge tool to be developed will identify more specific information regarding the nutrition knowledge needed.

 

Nutritional management of Children with Osteosarcoma
Providing multidisciplinary supportive care during cancer treatment is of extreme importance to enhance patient quality of life and ultimately to increase overall survival. Children with cancer are at risk of developing nutrition deficiencies as a result of both disease progression and treatment. Supportive nutrition care may offer such benefits as improved tolerance to chemotherapy, increased quality of life, and decreased risk of infection, in addition to preventing or reversing nutrition deficiencies. Providing timely and appropriate nutrition support is paramount to the attainment of such positive outcomes, yet guidelines regarding the most effective forms of nutrition support are lacking. The purpose of this retrospective study was to identify the types of nutrition support provided during treatment and to evaluate effectiveness of each.

 

Impact of Weight Status on the Outcome of Patients with Acute Myeloid Leukemia (AML)
The association of body mass index (BMI) with overall survival (OS) and event-free survival (EFS) in the AML patients treated in AML87, AML91, AML 97 and AML02 protocols will be explored. This analysis includes patients age 2 and greater who had AML (excluded bi-phenotypic and multi-lineage leukemia and patients with Downs syndrome).

 

The Newborn Pig Model of Chemotherapy-induced Mucositis
To validate the newborn pig as a model of chemotherapy-induced mucositis (CIM). This will be accomplished by evaluating the impact of chemotherapy regimens on gastrointestinal tract characteristics of newborn pigs.

 

The Role of Sodium in Causing HTN in the Pediatric HIV population

 

Nutritional Status and Quality of Life in Pediatric Osteosarcoma Patients During and Following Treatment
This is a study to assess associations among nutritional status (defined by the body mass index categorization of the Children’s Oncology Group), nutritional support (use of appetite stimulants, parenteral nutrition and enteral nutrition) and reported quality of life (QoL) in pediatric patients with osteosarcoma by conducting a secondary analysis of a previously conducted study that assessed treatment effects on patients’ QoL at diagnosis, during therapy and after completion of therapy.

 

Pilot Test for a Newly Developed Nutrition Screening Method: Pediatric Subjective Global Assessment
The PEDSGA is a newly developed nutrition screening tool that is designed to involve the patient and the caregivers in determining the individual’s nutritional needs and to include them in the development of a care plan. This study will test the PEDSGA against the standard nutrition screening tool in order to determine if the PEDSGA is as good as or better at identifying patients at nutrition risk.

 

Diminished Bone Mineral Density in Survivors of Childhood Acute Lymphoblastic Leukemia (ALL): A Severity-Adapted Clinical Trial
St. Jude is participating in a study of bone mineral density in patients treated for acute lymphoblastic leukemia (ALL). One component of the study involves extensive nutritional counseling encouraging a high intake of calcium and vitamin D. A primary aim of the study is to investigate possible risk factors for the development of diminished bone mineral density, one of these being nutritional status.