Susana C. Raimondi, PhD

Susana C. Raimondi, PhD

Member, St. Jude Faculty
Director, Cytogenetics Laboratory

Departments

Pathology

Contact Information

Susana Raimondi, PhD
Pathology
MS 250, Room C4023A
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: susana.raimondi@stjude.org
Phone: (901) 595-3537

Education

PhD - University of Tennessee Center for the Health Sciences, Memphis


Research Interests


Selected Publications

Pollard JA, Alonzo TA, Loken M, Gerbing RB, Ho PA, Bernstein ID, Raimondi SC, Hirsch B, Franklin J, Walter RB, Gamis A, Meshinchi S. Correlation of CD33 expression level with disease characteristics and response to gemtuzumab ozogamicin containing chemotherapy in childhood AML. Blood 119(16):3705-11, 2012

Cooper TM, Franklin J, Gerbing RB, Alonzo TA, Hurwitz C, Raimondi SC, Hirsch B, Smith FO, Mathew P, Arceci RJ, Feusner J, Iannone R, Lavey RS, Meshinchi S, Gamis A. AAML03P1, a pilot study of the safety of gemtuzumab ozogamicin in combination with chemotherapy for newly diagnosed childhood acute myeloid leukemia. Cancer 118(3):761-9, 2012.

Mathew P, Gerbing R, Alonzo TA, Wallas T, Gong JZ, Jasty R, Jorstad DT, Raimondi SC, Chavez CM, Eisenberg NL, Hirsch B, Gamis A, Smith FO, Arceci RJ. A phase II study of amifostine in children with myelodysplastic syndrome: a report from the Children's Oncology Group study (AAML0121). Pediatr Blood Cancer 57(7):1230-2, 2011.

Debelenko LV, McGregor LM, Shivakumar BR, Dorfman HD, Raimondi SC. A novel EWSR1-CREB3L1 fusion transcript in a case of small cell osteosarcoma. Genes Chromosomes Cancer 50(12):1054-62, 2011.

Ho PA, Kopecky KJ, Alonzo TA, Gerbing RB, Miller KL, Kuhn J, Zeng R, Ries RE, Raimondi SC, Hirsch BA, Oehler V, Hurwitz CA, Franklin JL, Gamis AS, Petersdorf SH, Anderson JE, Godwin JE, Reaman GH, Willman CL, Bernstein ID, Radich JP, Appelbaum FR, Stirewalt DL, Meshinchi S. Prognostic implications of the IDH1 synonymous SNP rs11554137 in pediatric and adult AML: a report from the Children's Oncology Group and SWOG. Blood 118(17):4561-6, 2011.

Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, Easton J, Chen X, Wang J, Rusch M, Lu C, Chen SC, Wei L, Collins-Underwood JR, Ma J, Roberts KG, Pounds SB, Ulyanov A, Becksfort J, Gupta P, Huether R, Kriwacki RW, Parker M, McGoldrick DJ, Zhao D, Alford D, Espy S, Bobba KC, Song G, Pei D, Cheng C, Roberts S, Barbato MI, Campana D, Coustan-Smith E, Shurtleff SA, Raimondi SC, Kleppe M, Cools J, Shimano KA, Hermiston ML, Doulatov S, Eppert K, Laurenti E, Notta F, Dick JE, Basso G, Hunger SP, Loh ML, Devidas M, Wood B, Winter S, Dunsmore KP, Fulton RS, Fulton LL, Hong X, Harris CC, Dooling DJ, Ochoa K, Johnson KJ, Obenauer JC, Evans WE, Pui CH, Naeve CW, Ley TJ, Mardis ER, Wilson RK, Downing JR, Mullighan CG. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature 481(7380):157-63, 2012.

Ho PA, Kutny MA, Alonzo TA, Gerbing RB, Joaquin J, Raimondi SC, Gamis AS, Meshinchi S. Leukemic mutations in the methylation-associated genes DNMT3A and IDH2 are rare events in pediatric AML: a report from the Children's Oncology Group. Pediatr Blood Cancer 57(2):204-9, 2011.

Coenen EA, Raimondi SC, Harbott J, Zimmermann M, Alonzo TA, Auvrignon A, Beverloo HB, Chang M, Creutzig U, Dworzak MN, Forestier E, Gibson B, Hasle H, Harrison CJ, Heerema NA, Kaspers GJL, Leszl A, Litvinko N, Lo Nigro L, Morimoto A, Perot C, Reinhardt D, Rubnitz JE, Smith FO, Stary J, Stasevich I, Strehl S, Taga T, Tomizawa D, Webb D, Zemanova Z, Pieters R, Zwaan CM, van den Heuvel-Eibrink MM. Prognostic significance of additional cytogenetic aberrations in 733 de novo pediatric 11q23/MLL-rearranged AML patients: results of an international study. Blood, 117(26):7102-11, 2011.

Mitra AK, Crews KR, Pounds S, Cao X, Feldberg T, Ghodke Y, Gandhi V, Plunkett W, Dolan ME, Hartford C, Raimondi S, Campana D, Downing J, Rubnitz JE, Ribeiro RC, Lamba JK. Genetic variants in cytosolic 5 '-nucleotidase II are associated with its expression and cytarabine sensitivity in HapMap cell lines and in patients with acute myeloid leukemia. J Pharmacol Exp Ther 339(1):9-23, 2011.

Bhojwani D, Pei D, Sandlund JT, Jeha S, Ribeiro RC, Rubnitz JE, Raimondi SC, Shurtleff S, Onciu M, Cheng C, Coustan-Smith E, Bowman WP, Howard SC, Metzger ML, Inaba H, Leung W, Evans WE, Campana D, Relling MV, Pui CH. ETV6-RUNX1-positive childhood acute lymphoblastic leukemia: improved outcome with contemporary therapy. Leukemia August 26, 2011.

Mitra AK, Crews K, Pounds S, Cao X, Downing JR, Raimondi S, Campana D, Ribeiro RC, Rubnitz JE, Lamba JK. Impact of genetic variation in FKBP5 on clinical response in pediatric acute myeloid leukemia patients: a pilot study. Leukemia 25(8):1354-6, 2011.

Berman JN, Gerbing RB, Alonzo TA, Ho PA, Miller K, Hurwitz C, Heerema NA, Hirsch B, Raimondi SC, Lange B, Franklin JL, Gamis A, Meshinchi S. Prevalence and clinical implications of NRAS mutations in childhood AML: a report from the Children's Oncology Group. Leukemia 25(6):1039-1042, 2011.

Andersson AK, Miller DW, Lynch JA, Lemoff AS, Cai Z, Pounds SB, Radtke I, Yan B, Schuetz JD, Rubnitz JE, Ribeiro RC, Raimondi SC, Zhang J, Mullighan CG, Shurtleff SA, Schulman BA, Downing JR. IDH1 and IDH2 mutations in pediatric acute leukemia. Leukemia June 7, 2011.

Lamba JK, Crews KR, Pounds SB, Cao X, Gandhi V, Plunkett W, Razzouk BI, Lamba V, Baker SD, Raimondi SC, Campana D, Pui CH, Downing JR, Rubnitz JE, Ribeiro RC. Identification of predictive markers of cytarabine response in AML by integrative analysis of gene-expression profiles with multiple phenotypes. Pharmacogenomics 12(3):327-39, 2011.

Mikkelsen TS, Sparreboom A, Cheng C, Zhou Y, Boyett JM, Raimondi SC, Panetta JC, Bowman WP, Sandlund JT, Pui CH, Relling MV, Evans WE. Shortening infusion time for high-dose methotrexate alters antileukemic effects: a randomized prospective clinical trial. J Clin Oncol March 28, 2011.

Inaba H, Londero M, Maurer SH, Onciu M, Ge Y, Taub JW, Rubnitz JE, Raimondi SC. Acute megakaryoblastic leukemia without GATA1 mutation after transient myeloproliferative disorder in an infant without Down syndrome. J Clin Oncol January 4, 2011.

Ho PA, Kuhn J, Gerbing RB, Pollard JA, Zeng R, Miller KL, Heerema NA, Raimondi SC, Hirsch BA, Franklin JL, Lange B, Gamis AS, Alonzo TA, Meshinchi S. WT1 synonymous SNP rs16754 correlates with higher mRNA expression and predicts significantly improved outcome in favorable-risk pediatric acute myeloid leukemia: a report from the Children's Oncology Group. J Clin Oncol December 28, 2010.

Pui CH, Pei D, Campana D, Bowman WP, Sandlund JT, Kaste SC, Ribeiro RC, Rubnitz JE, Coustan-Smith E, Jeha S, Cheng C, Metzger ML, Bhojwani D, Inaba H, Raimondi SC, Onciu M, Howard SC, Leung W, Downing JR, Evans WE, Relling MV. Improved prognosis for older adolescents with acute lymphoblastic leukemia. J Clin Oncol December 20, 2010.

Ho PA, Zeng R, Alonzo TA, Gerbing RB, Miller KL, Pollard JA, Stirewalt DL, Heerema NA, Raimondi SC, Hirsch B, Franklin JL, Lange B, Meshinchi S. Prevalence and prognostic implications of WT1 mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group. Blood 116(5):702-710, 2010.

Pollard JA, Alonzo TA, Gerbing RB, Ho PA, Zeng R, Ravindranath Y, Dahl G, Lacayo NJ, Becton D, Chang M, Weinstein HJ, Hirsch B, Raimondi SC, Heerema NA, Woods WG, Lange BJ, Hurwitz C, Arceci RJ, Radich JP, Bernstein ID, Heinrich MC, Meshinchi S. Prevalence and prognostic significance of KIT mutations in pediatric patients with core binding factor AML enrolled on serial pediatric cooperative trials for de novo AML. Blood 115(12):2372-2379, 2010.

Macedo Silva ML, Pombo-de-Oliveira MS, Raimondi SC, Mkrtchyan H, Abdelhay E, Figueiredo AF, Souza MT, Ribeiro Ney Garcia D, Soares de Ventura EM, Sousa AM, Liehr T. Unbalanced chromosome 1 abnormalities leading to partial trisomy 1q in four infants with Down syndrome and acute megakaryocytic leukemia. Molecular Cytogenetics 2:7, 2009 [DOI:10.1186/1755-8166-2-7]

Coustan-Smith E, Mullighan CG, Onciu M, Behm FG, Raimondi SC, Pei D, Chen C, Rubnitz JE, Basso G, Biondi A, Pui C-H, Downing JR, Campana D. Early T-cell precursor leukemia: a subtype of very high-risk acute lymphoblastic leukemia. Lancet Oncology 10(2):147-146, 2009.

de Jesus Marques-Salles T, Liehr T, Mkrtchyan H, Raimondi SC, Tavares de Souza M, Faria de Figueiredo A, Rouxinol S, Jordy Macedo FC, Abdelhay E, Santos N, Macedo Silva ML. A new chromosomal three-way rearrangement involving MLL masked by a t(9;19)(p11;p13) in an infant with acute myeloid leukemia. Cancer Genetics Cytogenetics 189 (1) 59-62, 2009.

Pounds S, Cheng C, Mullighan C, Raimondi SC, Shurtleff S, Downing JR. Reference alignment of SNP microarray signals for copy number analysis of tumors. Bioinformatics 25(3):315-321, 2009.

French D, Yang W, Cheng C, Raimondi SC, Mullighan CG, Downing JR, Evans WE, Pui C-H, Relling MV. Acquired variation outweighs inherited variation in whole genome analysis of methotrexate accumulation in leukemia. Blood 209: 4512-4520, 2009.

Pollard JA, Alonzo T, Gerbing R, Zeng R, Hirsch B, Raimondi SC, Heerema NA, Woods WG, Lange B, Hurwitz C, Arceci R, Radich JP, Bernstein ID, Heinrich M, Meshinchi S. Prevalence and prognostic significance of KIT mutations in pediatric core binding factor acute myeloid leukemia patients enrolled on serial CCG/COG protocols. Blood 110:1442, 2008.

Silva MLM, Raimondi SC, Abdelhay E, Gross M, Mkrtchyan H, de Figueiredo AF, Ribeiro RC, Marques-Salles TD, Sobral ES, Land MPG, Liehr T. Banding and molecular cytogenetic studies detected a CBFB-MYH11 fusion gene that appeared as abnormal chromosomes 1 and 16 in a baby with acute myeloid leukemia FAB M4-Eo. Cancer Genetics Cytogenetics 182 (1) 56-60, 2008.

O’Brien MM, Taub JW, Chang M, Massey GV, Stine KC, Raimondi SC, Becton D, Ravindranath Y, Dahl GV. Cardiomyopathy in children with Down syndrome treated for acute myeloid leukemia: A report from the Children’s Oncology Group Study POG 9421. J Clin Oncol 26 (3) 414-420, 2008.

Hartford C, Yang W, Cheng C, Fan Y, Liu W, Trevino L, Pounds S, Neale G, Raimondi SC, Bogni A, Dolan ME, Pui C-H, Relling MV. Genome scan implicates adhesion biological pathway in secondary leukemia. Leukemia 21 (10) 2128-2136, 2007.

Raimondi SC. T-lineage acute lymphoblastic leukemia (T-ALL). Atlas Genet Cytogenet Oncol Haematol May 2007. :http://www.infobiogen.fr/services/chromcancer/Anomalies/T-ALL.
URL [http://AtlasGeneticsOncology.org/Anomalies/TALLID1374.html ]

Heerema NA, Raimondi SC, Anderson JR, Biegel J, Camitta BM, Cooley LD, Gaynon PS, Hirsch B, Magenis RE, McGavran L, Patil S, Pettenati MJ, Pullen J, Rao K, Roulston D, Schneider NR, Shuster JJ, Sanger W, Sutcliffe MJ, van Tuinen P, Watson MS, Carroll AJ. Specific extra chromosomes occur in a modal number dependent pattern in pediatric acute lymphoblastic leukemia. Genes Chromosomes Cancer 46 (7) 684-693, 2007.

Hertzberg L, Betts D, Raimondi SC, Schaefer BW, Notterman DA, Domany E, Izraeli S. Prediction of chromosomal aneuploidy from gene expression data. Genes Chromosomes Cancer (46) 75-86, 2007.

Hasle H, Alonzo TA, Auvrignon A, Behar C, Chang M, Creutzig U, Fischer A, Forestier E, Fynn A, Haas OA, Harbott J, Harrison CJ, Heerema NA, van den Heuvel-Eibrink MM, Kaspers GJL, Locatelli F, Noellke P, Polychronopoulou NS, Ravindranath Y, Razzouk B, Reinhardt D, Savva NN, Stark B, Suciu S, Tsukimoto I, Webb DK, Wojcik D, Woods WG, Zimmermann M, Niemeyer CM, Raimondi SC. Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia: An international retrospective study. Blood 109 (11) 4641-4647, 2007.

Wagner LM, Burger RA, Guichard SM, Raimondi SC, Santana VM, Furman WL, Danks MK. Pilot study to evaluate MYCN expression as a neuroblastoma cell marker to detect minimal residual disease by RT-PCR. J Pediatr Hematol Oncol 28: 635-641, 2006.

Savasan S, Buck S, Weinstein H, Raimondi SC, Ravindranath Y. CD36 (thrombospondin receptor) expression in childhood acute megakaryoblastic leukemia: in vitro drug sensitivity and outcome. Leuk Lymphoma 47 (10) 2076-2083, 2006.

Onciu M, Schlette E, Zhou Y, Raimondi SC, Giles FJ, Kantarjian HM, Medeiros LJ, Ribeiro RC, Pui C-H, Sandlund JT. Secondary chromosomal abnormalities predict outcome in pediatric and adult high-stage Burkitt lymphoma. Cancer 107 (5) 1084-1092, 2006.

Raimondi SC, Zhou Y, Shurtleff S, Rubnitz JE, Pui C-H, Behm FG. Near-triploidy (68 to 80 chromosomes) and near tetraploidy (>80 chromosomes) in childhood acute lymphoblastic leukemia: Association with B-lineage blast cells with the ETV6-CBFA2 (TEL-AML1) fusion, with the T-cell immunophenotype, and with a favorable outcome. Cancer Genetics Cytogenetics 169:50-57, 2006.

Sandlund JT, Kastan MB, Kennedy W, Behm FG, Entrekin RE, Pui C-H, Kalwinsky DT, Raimondi SC. A subtle t(3;8) translocation results in juxtaposition of CMYC and BCL6 in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia. Cancer Genetics Cytogenetics 168:69-72, 2006.

Slovak ML, Gundacker H, Bloomfield CD, Dewald G, Appelbaum FR, Larson RA, Tallman MS, Bennett JM, Stirewalt DL, Meshinchi S, Willman CL, Ravindranath Y, Alonzo TA, Carroll AJ, Raimondi SC, Heerema NA. A t(6;9) retrospective study of 69 patients with t(6;9)(p23;q34) AML emphasizes the need for a prospective, multicenter initiative for rare "poor prognosis" myeloid malignancies. Leukemia20:1295-1297, 2006.

DiMartino JF, Norman J Lacayo NJ, Varadi M, Li L, Saraiya C, Ravindranath Y, Yu R, Sikic B, Raimondi SC, Dahl GV. Low or absent SPARC expression in acute myeloid leukemia with MLL rearrangements is associated with sensitivity to growth inhibition by exogenous SPARC protein. Leukemia 20:426-432, 2006.

Becton D, Dahl GV, Ravindranath Y, Chang MN, Behm FG, Raimondi SC, Head DR, Stine KC, Lacayo NJ, Sikic BI, Arceci RJ, Weinstein H. Randomized use of Cyclosporin A (CSA) to modulate P-glycoprotein in children with AML in remission: Pediatric Oncology Study 9421. Blood 107, 1315-1324, 2006.

Woodard P, Barfield R, Hale G, Horwitz E, Leung W, Ribeiro R, Rubnitz J, Srivistava DK, Tong X, Yusuf U, Raimondi S, Pui C-H, Handgretinger R, Cunningham JM. Outcome of hematopoietic stem cell transplantation for pediatric patients with therapy-related acute myelogenous leukemia or myelodysplastic syndrome. Pediatric Blood Cancer (e-print Sept 2005) 47:931-5, 2006.

Ravindranath Y, Chang M, Steuber CP, Becton D, Dahl G, Civin C, Camitta B, Carroll A, Raimondi SC, HJ Weinstein, for the Pediatric Oncology Group. Pediatric Oncology Group (POG) studies of Acute Myeloid Leukemia (AML): A review of four consecutive childhood AML trials conducted between 1981 and 2000. Leukemia 19, 2101-2116, 2005.

Cheng Q, Yang WJ, Raimondi SC, Pui C-H, Relling MV, Evans WE. Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes. Nature Genetics 37, 878-882, 2005.

Moorman AV, Raimondi SC, Pui C-H, Baruchel A, Biondi A, Carroll AJ, Forestier E, Gaynon PS, Harbott J, Harms DO, Heerema N, Pieters R, Schrappe M, Silverman LB, Vilmer E, Harrison CJ, on behaf of the Ponte di Legno working group. No prognostic effect of additional chromosomal abnormalities in children with acute lymphoblastic leukemia and 11q23 abnormalities. Leukemia 19, 557-563, 2005.

Hijiya N, Gajjar A, Zhang Z, Sandlund JT, Ribeiro RC, Rubnitz JE, Jeha S, Lui W, Cheng C, Raimondi SC, Behm FG, Rivera GK, Relling MV, Pui C-H. Low-dose oral etoposide-based induction regimen for children with acute lymphoblastic leukemia in first bone marrow relapse. Leukemia 18, 1581-1586, 2004.

Ross ME, Mahfouz R, Onciu M, Liu H-C, Zhou X, Song G, Shurtleff SA, Pounds S, Cheng C, Ma J, Ribeiro RC, Rubnitz JE, Girtman K, Williams WK, Raimondi SC, Liang D-C, Shih L-Y, Pui C-H, Downing JR. Gene expression profiling of pediatric acute myelogenous leukemia. Blood 104:3679-3687, 2004.

Pui C-H, Sandlund TJ, Pei D, Campana D, Rivera GK, Ribeiro RC, Rubnitz JE, Razzouk BI, Howard SC, Hudson MM, Cheng C, Kun LE, Raimondi SC, Behm FG, Downing JR, Relling MV, Evans WE. Improved outcome for children with acute lymphoblastic leukemia: results of Total Therapy Study XIIIB at St Jude Children’s Research Hospital. Blood 104:2690-2696, 2004.

Hijiya N, Gajjar A, Zhang Z, Sandlund JT, Ribeiro RC, Rubnitz JE, Jeha S, Liu W, Cheng C, Raimondi SC, Behm FG, Rivera GK, Relling MV, Pui C-H. Low-dose oral etoposide–based induction regimen for children with acute lymphoblastic leukemia in first bone marrow relapse. Leukemia 18:1581-1586, 2004.

Heerema NA, Harbott J, Galimberti S, Camitta BM, Gaynon PS, Janka-Schaub G, Kamps W, Basso G, Pui C-H, Schrappe M, Auclerc M-F, Carroll AJ, Conter V, Harrison CJ, Pullen J, Raimondi SC, Richards S, Riehm H, Sather HN, Shuster JJ, Silverman LB, Valsecchi MG, Aricò M. Secondary cytogenetic aberrations in childhood Philadelphia chromosome positive acute lymphoblastic leukemia are non-random and may be associated with outcome. Leukemia 18:693-702, 2004.

Raimondi SC. 11q23 rearrangements in childhood acute lymphoblastic leukemia. Atlas Genet Cytogenet Oncol Haematol February 2004.

Raimondi SC. Book review: Textbook of Malignant Haematology. N Engl J Med 341(1):62, 1999.


Last update: July 2012