Medicine and Science News Releases

View recent medicine and science-related news releases.

Protein identified that serves as a “brake” on inflammation

Results of the St. Jude Children’s Research Hospital-led study provide a target for developing novel therapies to tame the inflammation that drives autoinflammatory diseases. (Thirumala-Devi Kanneganti, PhD)

St. Jude Children’s Research Hospital opens seventh affiliate clinic

Addition extends access to clinical trials at St. Jude to children beyond its physical walls through clinical, research and academic affiliations with medical centers in six states.

St. Jude Children’s Research Hospital scientific director announces resignation

Richard Gilbertson, M.D., Ph.D., to become director of the Cambridge Cancer Centre in England (Richard Gilbertson, MD, PhD)

Experiments reveal key components of the body’s machinery for battling deadly tularemia

St. Jude Children’s Research Hospital scientists have discovered major “switches” that activate the immune system to kill the bacterium, potentially leading to protective drugs and vaccines. (Thirumala-Devi Kanneganti, PhD)

Scientists trace genomic evolution of high-risk leukemia

Whole exome sequencing of 20 pediatric ALL patients yielded important insights into the genetic basis of ALL treatment failure. The findings may lead to early detection of the mutations that drive ALL relapse. (Jinghui Zhang, PhD, and Charles G. Mullighan, MBBS(Hons), MSc, MD)

Measuring treatment response proves to be a powerful tool for guiding leukemia treatment

Measuring the concentration of leukemia cells in patient bone marrow during the first 46 days of chemotherapy helps boost survival of young leukemia patients by better matching patients with the right intensity of chemotherapy. (Ching-Hon Pui, MD)

St. Jude Children’s Research Hospital appoints new chair of Department of Radiation Oncology

Thomas Merchant, D.O., Ph.D., to oversee radiotherapy programs for the treatment of childhood cancer. (Thomas Merchant, DO, PhD)

Chromosomal rearrangement is the key to progress against aggressive infant leukemia

St. Jude Children’s Research Hospital—Washington University Pediatric Cancer Genome Project study highlights need for targeted therapies against a rare infant leukemia with a poor prognosis. (James R. Downing, MD)

Researchers map "genomic landscape" of childhood adrenocortical tumors for the first time

St. Jude Children’s Research Hospital scientists identify key molecular events in pediatric adrenocortical tumors; findings could help clinicians identify most malignant subtypes and lead to better treatment. (Raul Ribeiro, MD; Jinghui Zhang, PhD; and Gerard Zambetti, PhD)

St. Jude Children’s Research Hospital makes FORTUNE's “100 Best Companies to Work For” list for fifth straight year

St. Jude Children’s Research Hospital has been recognized for the fifth year in a row as one of FORTUNE magazine’s “100 Best Companies to Work For.”

Sun damage causes genetic changes that predispose children and adolescents to melanoma

St. Jude Children’s Research Hospital—Washington University Pediatric Cancer Genome Project has identified the genetic basis of three pediatric melanoma subtypes; findings could lead to better diagnosis and treatment. (Alberto Pappo, MD and Armita Bahrami, MD)

Inherited gene variation leaves young leukemia patients at risk for peripheral neuropathy

Research led by St. Jude Children’s Research Hospital investigators could help reduce side effects associated with the anti-cancer drug vincristine, which is widely used to treat cancer in children and adults. (William E. Evans, PharmD)

Possible strategy identified to combat major parasitic tropical disease

St. Jude Children’s Research Hospital scientists report results that suggest neutralizing a single protein may aid fight against a parasitic tropical disease that annually sickens more than 1.3 million people worldwide. (Thirumala-Devi Kanneganti, PhD)

Survivors of childhood cancer at risk for developing hormone deficiencies as adults

St. Jude Children’s Research Hospital finds childhood cancer patients treated with cranial irradiation may have hormone deficiencies that impact health decades later; results highlight need for lifelong health screenings. (Wassim Chemaitilly, MD)

Inherited gene variations tied to treatment-related hearing loss in cancer patients

St. Jude Children’s Research Hospital scientists have identified inherited genetic variations associated with hearing loss in young cancer patients treated with cisplatin, a drug widely used to treat adults with cancer. (Jun J. Yang, PhD, Clinton Stewart, PhD, and Giles Robinson, MD)

St. Jude Children’s Research Hospital scientist honored for contributions to immunology

Thirumala-Devi Kanneganti, Ph.D., of St. Jude Children’s Research Hospital, is recognized by the American Association of Immunologists for outstanding research contributions to the field of immunology. (Thirumala-Devi Kanneganti, PhD)

Inherited gene variation helps explain drug toxicity in patients of East Asian ancestry

St. Jude researchers have identified an inherited variation in the NUDT15 gene that is strongly associated with a low tolerance for a drug that is a mainstay of pediatric ALL treatment. The finding is expected to impact ALL treatment. (Jun J. Yang, PhD)

Tumor suppressor protein plays key role in maintaining immune balance

St. Jude Children’s Research Hospital scientists show that the PTEN tumor suppressor protein is essential for proper regulatory T cell function; discovery offers new focus for improving treatment of autoimmune diseases. (Hongbo Chi, PhD)