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Finding Cures. Saving Children.
Biostatistics
The mission of the Department of Biostatistics is to promote clinical, translational and laboratory investigations through the further development and creative application of statistical science including interfaces with biology, medicine and information technology.
Well-designed and well-executed studies provide the best opportunity for the advancement of clinical, translational and laboratory research. Our highest priority is the design of investigational clinical protocols and experiments that meet these criteria. To ensure that investigators have access to uniformly high-quality, innovative statistical science for clinical trials design, we use an internal peer review system. This process, which is sanctioned by the institution’s senior leadership, requires that all clinical protocols designed at St. Jude be reviewed and approved by the Protocol Review Committee (PRC) of the Department of Biostatistics. In addition to clinical and translational investigations, we are actively involved in the design and analyses of laboratory-based experiments, including genetics and genomic studies. We are the Operations and Biostatistics Center (OBC) for the Pediatric Brain Tumor Consortium (PBTC).
Our own research includes the development of robust statistical methods, group sequential designs, and novel statistical methods to support computational biology including normalization of SNP array data, estimation of false discovery rates and sample size estimation for microarray experiments. Education also continues to be a departmental priority. In collaboration with the Department of Oncology we offer a monthly journal club in which critiques of published biomedical studies of interest to St. Jude investigators serve to educate statisticians and researchers about one another’s work; and in collaboration with bioinformaticists in the Hartwell Center conduct a monthly workshop to discuss our ongoing computational biology projects. We support assistantships for PhD candidates at the University of Memphis in statistics (3) and computer science (1).
Teams consisting of faculty and masters-trained biostatisticians are dedicated to specific research areas to foster productive collaborations. Additionally, six computer scientists, one administrative director and three administrative assistants play key roles in this effort. Supporting the mission of the PBTC within the OBC, there are four protocol coordinators and a fiscal director.
St. Jude's Biostatistics Department is chaired by James Boyett, PhD.
