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Research
| Technology Name (St. Jude Reference #) |
In Vivo Selection of Primitive Hematopoietic Cells (SJ-95-0010) |
| Description | This invention describes a method that selects genetically modified hematopoietic progenitor or stem cells from unmodified hematopoietic cells. This is achieved by introducing a mutant dihydrofolate reductase (DHFR) gene that confers antifolate resistance into hematopoietic progenitor or stem cells and then administering an antifolate, which inhibits the growth of unmodified cells and a nucleoside transport inhibitor to block the salvage pathway. Cells that do not have the mutant DHFR gene cannot synthesize new nucleosides and the salvage for exogenous nucleosides is also blocked; therefore growth of unmodified cells is arrested. The invention also includes nucleic acids which encode mutant DHFR genes and hematopoietic cells transformed with such mutant genes. |
| Keywords | Gene therapy, DHFR |
| Granted Patents or Published Applications | US Patent No. 6,500,421 |
| Related Scientific References | Allay, JA., et al., "In vivo Selection of Retrovirally Transduced Hematopoietic Stem Cells" Nature Medicine 4: 1136-1143 (1998) |
| Licensing Opportunities | We are seeking licensees in all fields for the development of this technology. |
Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.
Last update: June 2006
