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St. Jude Children’s Research Hospital advances understanding of how T cells craft an appropriate immune response; setting the stage for new strategies to intervene if the system goes awry. (Dr. Dario Vignali)
St. Jude investigators have discovered how destructive immune cells gain access to insulin-producing cells and help cause diabetes.
From the laboratory of Dario Vignali, PhD, Immunology, comes new evidence that like unruly children who secretly welcome the intervention of a stern teacher, certain aggressive lymphocytes invite suppression by other immune cells.
Scientists at St. Jude have discovered an important signaling molecule that puts the brakes on a rogue immune response. The discovery could have applications for a host of autoimmune and inflammatory diseases, including type 1 diabetes, multiple sclerosis, Crohn’s disease and asthma. The finding could also have exciting ramifications for fighting cancer.
The discovery of a new cytokine called IL-35 could allow clinicians to treat diseases by turning up or down the immune response.
The complex task of launching a well-organized, effective immune system attack on specific targets is thrown into high gear when either of two specific enzymes chops a protein called LAG-3 off the immune cells leading that battle.
St. Jude investigators have developed a technique that significantly reduces the time and expense of studying how the body produces immune system cells called T lymphocytes that aggressively attack germs, cancer and other harmful targets.