Paul Brindle, PhD

Paul K. Brindle, PhD

Associate Member, St. Jude Faculty

Departments

Biochemistry

Contact Information

Paul Brindle, PhD
Biochemistry
Room D4007E
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: paul.brindle@stjude.org
Phone: (901) 595-2522
FAX: (901) 525-8025

Education

PhD - University of California, Davis


Research Interests

CBP & p300 interactome database


Selected Publications

Seth A, Ye J, Yu N, Guez F, Bedford DC, Neale GA, Cordi S, Brindle PK, Lemaigre FP, Kaestner KH, Sosa-Pineda B. Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development 141:538-47, 2014.

Kasper LH, Fukuyama T, Lerach S, Chang Y, Xu W, Wu S, Boyd KL, Brindle PK. Genetic Interaction between Mutations in c-Myb and the KIX Domains of CBP and p300 Affects Multiple Blood Cell Lineages and Influences Both Gene Activation and Repression. PLoS One 8:e82684, 2013. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0082684

Wolf L, Harrison W, Huang J, Xie Q, Xiao N, Sun J, Kong L, Lachke SA, Kuracha MR, Govindarajan V, Brindle PK, Ashery-Padan R, Beebe DC, Overbeek PA, Cvekl A. Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300. Nucleic Acids Res 41:10199-214, 2013. 

Liu Y, Wang L, Predina J, Han R, Beier UH, Wang L-CS, Kapoor V, Bhatti TR, Akimova T, Singhal S, Brindle PK, Cole PA, Albelda SM, Hancock WW. Inhibition of p300 impairs Foxp3+ T-regulatory cell function and promotes anti-tumor immuniy. Nature Medicine 19:1173-7, 2013. 

Peifer M, Fernández-Cuesta L, Sos ML, George J, Seidel D, Kasper LH, Plenker D, Leenders F, Sun R, Zander T, Menon R, Koker M, Dahmen I, Müller C, Di Cerbo V, Schildhaus HU, Altmüller J, Baessmann I, Becker C, de Wilde B, Vandesompele J, Böhm D, Ansén S, Gabler F, Wilkening I, Heynck S, Heuckmann JM, Lu X, Carter SL, Cibulskis K, Banerji S, Getz G, Park KS, Rauh D, Grütter C, Fischer M, Pasqualucci L, Wright G, Wainer Z, Russell P, Petersen I, Chen Y, Stoelben E, Ludwig C, Schnabel P, Hoffmann H, Muley T, Brockmann M, Engel-Riedel W, Muscarella LA, Fazio VM, Groen H, Timens W, Sietsma H, Thunnissen E, Smit E, Heideman DA, Snijders PJ, Cappuzzo F, Ligorio C, Damiani S, Field J, Solberg S, Brustugun OT, Lund-Iversen M, Sänger J, Clement JH, Soltermann A, Moch H, Weder W, Solomon B, Soria JC, Validire P, Besse B, Brambilla E, Brambilla C, Lantuejoul S, Lorimier P, Schneider PM, Hallek M, Pao W, Meyerson M, Sage J, Shendure J, Schneider R, Büttner R, Wolf J, Nürnberg P, Perner S, Heukamp LC, Brindle PK, Haas S, Thomas RK. Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat Genet 44:1104-10, 2012.

Bedford DC, Brindle PK. Is histone acetylation the most important physiological function for CBP and p300? Aging 4:247-55, 2012.

Bedford DC, Kasper LH, Wang R, Chang Y, Green DR, Brindle PK. Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control. Cell Metab 14:219-30, 2011.

Oliveira AMM, Estévez MA, Hawk JD, Grimes S, Brindle PK, Abel T. Subregion-specific p300 conditional knock-out mice exhibit long-term memory impairment. Learning and Memory 18:161-169, 2011.

Kasper LH, Thomas MC, Zambetti GP, Brindle PK. Double null cells reveal that CBP and p300 are dispensable for p53 targets p21 and Mdm2 but variably required for target genes of other signaling pathways. Cell Cycle 10:212-21, 2011.

Pasqualucci L, Dominguez-Sola D, Chiarenza A, Fabbri G, Grunn A, Trifonov V, Kasper LH, Lerach S, Ma J, Rossi D, Mullighan C, Gaidano G, Rabadan R, Brindle PK, Dalla-Favera R. Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature 471:189-95, 2011.  Faculty of 1000 evaluation

Mullighan CG, Zhang J, Kasper LH, Lerach S, Payne-Turner D, Phillips LAA, Heatley SL, Holmfeldt L, Collins-Underwood JR, Ma J, Buetow KH, Pui C-H, Baker SD, Brindle PK, Downing JR. CREBBP mutations in relapsed acute lymphoblastic leukemia. Nature 471:235-9, 2011.  Faculty of 1000 evaluation

Jin Q, Yu L-R, Wang L, Zhang Z, Kasper LH, Lee J-E, Wang C, Brindle PK, Dent SYR, Ge K. Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation. EMBO J 30:249-62, 2011.

Kasper LH, Lerach S, Wang W, Wu S, Jeevan T, Brindle PK. CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation. EMBO J 29:3660-72, 2010.

Bedford DC, Kasper LH, Fukuyama T, Brindle PK. Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases. Epigenetics 5(1), 2010.

Brindle PK. Transcriptional Regulation via the cAMP Responsive Activator CREB. Handbook of Cell Signaling. Ralph Bradshaw and Edward Dennis, Editors-in Chief. Elsevier Second edition, pp. 2077-2081, 2009.

Fukuyama T, Kasper LH, Boussouar F, Jeevan T, van Deursen J, Brindle PK. Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8 T cell development. Mol Cell Biol 29:3894-3904, 2009.

Xu W, Kasper LH, Lerach S, Jeevan, T, Brindle PK. Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanisms. EMBO J 26:2890-903, 2007.

Vecsey GC, Hawk JD, Lattal KM, Stein JM, Fabian SA, Attner, MA, Cabrera SM, McDonough CB, Brindle PK, Abel T, Wood MA. Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation. J Neurosci 27:6128-6140, 2007

Wood MA, Attner MA, Oliveira AMM, Brindle PK, Abel T.  A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and expression of specific target genes. Learn Mem 13:609-17, 2006.

Oliveira AMM, Abel T, Brindle PK, Wood MA.. Differential Role for CBP and p300 CREB-Binding Domain in Motor Skill Learning. Behav Neurosci 120:724-729, 2006.

Kasper LH, Fukuyama T, Biesen MA, Boussouar F, Tong C, de Pauw A, Murray PJ, van Deursen JMA, Brindle PK. Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development. Mol Cell Biol 26:789-809, 2006.

Xu W, Fukuyama T, Ney P, Wang D, Rehg J, Boyd K, van Deursen JMA, Brindle PK. Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B-cells. Blood 107: 4407-4416, 2006.

Kasper LH, Brindle PK. Mammalian Gene Expression Program Resiliency: The Roles of Multiple Coactivator Mechanisms in Hypoxia Responsive Transcription. Cell Cycle 5, 2006.

Kasper LH, Boussouar F, Boyd K, Xu W, Biesen M, Rehg J, Baudino TA, Cleveland JL, Brindle PK. Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. Embo J 24:3846-3858, 2005.

Koo SH, Flechner L, Qi L, Zhang X, Screaton RA, Jeffries S, Hedrick S, Xu W, Boussouar F, Brindle P, Takemori H, Montminy M. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature 437:1109-1114, 2005.  Faculty of 1000 evaluation

N Kang-Decker, C Tong, F Boussouar, DJ Baker, W Xu, AA Leontovich, W R Taylor, PK Brindle and J MA van Deursen. Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency. Cancer Cell 5:177-189, 2004.

Kasper LH, Boussouar F, Ney PA, Jackson CW, Rehg J, van Deursen JM, Brindle PK. A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature 419:738-743, 2002.

Nakajima H, Brindle PK, Handa M, Ihle JN. Functional interaction of STAT5 and nuclear receptor corepressor SMRT; implications in negative regulation of STAT5-dependent transcription. EMBO J 20:6836-6844, 2001.

Parker D, Rivera M, Zor T, Henrion-Caude A, Radhakrishnan I, Kumar A, Shapiro LH, Wright PE, Montminy M, Brindle PK. Role of secondary structure in discrimination between constitutive and inducible activators. Mol Cell Biol 19:5601-5607, 1999.

Kasper LH, Brindle PK, Schnabel CA, Pritchard CEJ, Cleary ML, van Deursen JMA. CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity. Mol Cell Biol 19:764-776, 1999.

Yang C, Shapiro LH, Rivera M, Kumar A, Brindle PK. A role for CREB binding protein and p300 transcriptional coactivators in Ets-1 transactivation functions. Mol Cell Biol 18:2218-2229, 1998.

Last update: January 2014