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Finding Cures. Saving Children.
Paul K. Brindle, PhD
Associate Member, St. Jude Faculty
Departments
Biochemistry
Contact Information
Paul Brindle, PhD
Biochemistry
Room D4007E
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: paul.brindle@stjude.org
Phone: (901) 595-2522
FAX: (901) 525-8025
Education
PhD - University of California, Davis
Research Interests
- Gene regulatory networks
- In vivo functions of transcriptional coactivators
- Transcription factor interactions with coactivators
- Mechanisms of coordinate gene transcription
- Mouse genetics
CBP & p300 interactome database
Selected Publications
Bedford DC, Kasper LH, Fukuyama T, Brindle PK. Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases. Epigenetics 2009 (in press).
Brindle PK. Transcriptional Regulation via the cAMP Responsive Activator CREB. Handbook of Cell Signaling. Ralph Bradshaw and Edward Dennis, Editors-in Chief. Elsevier Second edition, pp. 2077-2081, 2009.
Fukuyama T, Kasper LH, Boussouar F, Jeevan T, van Deursen J, Brindle PK. Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T cell development. Mol Cell Biol 29:3894-3904, 2009.
Xu W, Kasper LH, Lerach S, Jeevan, T, Brindle PK. Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanisms. EMBO J 26:2890-903, 2007.
Vecsey GC, Hawk JD, Lattal KM, Stein JM, Fabian SA, Attner, MA, Cabrera SM, McDonough CB, Brindle PK, Abel T, Wood MA. Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation. J Neurosci 27:6128-6140, 2007
Wood MA, Attner MA, Oliveira AMM, Brindle PK, Abel T. A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and expression of specific target genes. Learn Mem 13:609-17, 2006.
Oliveira AMM, Abel T, Brindle PK, Wood MA.. Differential Role for CBP and p300 CREB-Binding Domain in Motor Skill Learning. Behav Neurosci 120:724-729, 2006.
Kasper LH, Fukuyama T, Biesen MA, Boussouar F, Tong C, de Pauw A, Murray PJ, van Deursen JMA, Brindle PK. Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development. Mol Cell Biol 26:789-809, 2006.
Xu W, Fukuyama T, Ney P, Wang D, Rehg J, Boyd K, van Deursen JMA, Brindle PK. Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B-cells. Blood 107: 4407-4416, 2006.
Kasper LH, Brindle PK. Mammalian Gene Expression Program Resiliency: The Roles of Multiple Coactivator Mechanisms in Hypoxia Responsive Transcription. Cell Cycle 5, 2006.
Kasper LH, Boussouar F, Boyd K, Xu W, Biesen M, Rehg J, Baudino TA, Cleveland JL, Brindle PK. Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. Embo J 24:3846-3858, 2005.
Koo SH, Flechner L, Qi L, Zhang X, Screaton RA, Jeffries S, Hedrick S, Xu W, Boussouar F, Brindle P, Takemori H, Montminy M. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature 437:1109-1114, 2005.
N Kang-Decker, C Tong, F Boussouar, DJ Baker, W Xu, AA Leontovich, W R Taylor, PK Brindle and J MA van Deursen. Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency. Cancer Cell 5:177-189, 2004.
Kasper LH, Boussouar F, Ney PA, Jackson CW, Rehg J, van Deursen JM, Brindle PK. A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature 419:738-743, 2002.
Nakajima H, Brindle PK, Handa M, Ihle JN. Functional interaction of STAT5 and nuclear receptor corepressor SMRT; implications in negative regulation of STAT5-dependent transcription. EMBO J 20:6836-6844, 2001.
Parker D, Rivera M, Zor T, Henrion-Caude A, Radhakrishnan I, Kumar A, Shapiro LH, Wright PE, Montminy M, Brindle PK. Role of secondary structure in discrimination between constitutive and inducible activators. Mol Cell Biol 19:5601-5607, 1999.
Kasper LH, Brindle PK, Schnabel CA, Pritchard CEJ, Cleary ML, van Deursen JMA. CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity. Mol Cell Biol 19:764-776, 1999.
Yang C, Shapiro LH, Rivera M, Kumar A, Brindle PK. A role for CREB binding protein and p300 transcriptional coactivators in Ets-1 transactivation functions. Mol Cell Biol 18:2218-2229, 1998.
Last update: November 2009
