Inherited risk factors increase odds of developing childhood acute lymphoblastic leukemia (video 2009)



Scientists at St. Jude Children’s Research Hospital have identified inherited variations in two genes that account for 37 percent of childhood acute lymphoblastic leukemia (ALL), including a gene that may help predict drug response. The findings stem from the first complete search of the human genetic blueprint or genome to look for inherited risk factors for ALL, the most common childhood cancer. Mary Relling, Pharm.D., St. Jude Pharmaceutical Sciences chair is the paper’s senior author.