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Research
| Technology Name (St. Jude Reference #) | Synthetic Natural Product Analogs as Anti-Cancer Agents (SJ-08-0026) |
| Description | Analogs of two bacterial natural products, FR901464 and pladienolide, that are known for their selective and potent in vivo anti-cancer activity are provided.These analogs can be made synthetically and have promising anti-cancer activity. Certain human lymphomas and some childhood tumors are potently and selectively killed by these compounds in in vitro experiments. These synthetic agents can be developed into new anti-cancer drugs.The most advanced agent, designated sudemycin F1, is a potential clinical candidate. |
| Keywords | sudemycin, pladienolide, cancer, natural product analogs |
| Granted Patents or Published Applications | Pending International PCT application published December 23, 2009 as WO 2009/155606 |
| Related Scientific References | Lagisetti, C. et al., “Antitumor Compounds Based on a Natural Product Consensus Pharmacophore”, J. Med. Chem. (2008) |
| Licensing Opportunities | We are currently seeking licensing opportunities in all fields for the development of this technology. |
Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.
Last update: September 2010
