Susana C. Raimondi, PhD

Susana C. Raimondi, PhD

Member, St. Jude Faculty
Director, Cytogenetics Laboratory

Departments

Pathology

Contact Information

Susana Raimondi, PhD
Pathology
MS 250, Room C4023A
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: susana.raimondi@stjude.org
Phone: (901) 595-3537

Education

PhD - University of Tennessee Center for the Health Sciences, Memphis


Research Interests

  • The cytogenetics of the leukemias and lymphomas in relation to: diagnosis, prognosis, disease course, and disease subtypes, as well as specific DNA changes and associated gene expression
  • Application of new diagnostic techniques in clinical medicine, mainly in molecular cytogenetics of neoplasias
  • Development of FISH technology to enhance our understanding of subtle/cryptic chromosomal rearrangements that escape conventional cytogenetic detection

Selected Publications

Macedo Silva ML, Pombo-de-Oliveira MS, Raimondi SC, Mkrtchyan H, Abdelhay E, Figueiredo AF, Souza MT, Ribeiro Ney Garcia D, Soares de Ventura EM, Sousa AM, Liehr T. Unbalanced chromosome 1 abnormalities leading to partial trisomy 1q in four infants with Down syndrome and acute megakaryocytic leukemia. Molecular Cytogenetics 2:7, 2009 [DOI:10.1186/1755-8166-2-7]

Coustan-Smith E, Mullighan CG, Onciu M, Behm FG, Raimondi SC, Pei D, Chen C, Rubnitz JE, Basso G, Biondi A, Pui C-H, Downing JR, Campana D. Early T-cell precursor leukemia: a subtype of very high-risk acute lymphoblastic leukemia. Lancet Oncology 10(2):147-146, 2009.

de Jesus Marques-Salles T, Liehr T, Mkrtchyan H, Raimondi SC, Tavares de Souza M, Faria de Figueiredo A, Rouxinol S, Jordy Macedo FC, Abdelhay E, Santos N, Macedo Silva ML. A new chromosomal three-way rearrangement involving MLL masked by a t(9;19)(p11;p13) in an infant with acute myeloid leukemia. Cancer Genetics Cytogenetics 189 (1) 59-62, 2009.

Pounds S, Cheng C, Mullighan C, Raimondi SC, Shurtleff S, Downing JR. Reference alignment of SNP microarray signals for copy number analysis of tumors. Bioinformatics 25(3):315-321, 2009.

French D, Yang W, Cheng C, Raimondi SC, Mullighan CG, Downing JR, Evans WE, Pui C-H, Relling MV. Acquired variation outweighs inherited variation in whole genome analysis of methotrexate accumulation in leukemia. Blood 209: 4512-4520, 2009.

Pollard JA, Alonzo T, Gerbing R, Zeng R, Hirsch B, Raimondi SC, Heerema NA, Woods WG, Lange B, Hurwitz C, Arceci R, Radich JP, Bernstein ID, Heinrich M, Meshinchi S. Prevalence and prognostic significance of KIT mutations in pediatric core binding factor acute myeloid leukemia patients enrolled on serial CCG/COG protocols. Blood 110:1442, 2008.

Silva MLM, Raimondi SC, Abdelhay E, Gross M, Mkrtchyan H, de Figueiredo AF, Ribeiro RC, Marques-Salles TD, Sobral ES, Land MPG, Liehr T. Banding and molecular cytogenetic studies detected a CBFB-MYH11 fusion gene that appeared as abnormal chromosomes 1 and 16 in a baby with acute myeloid leukemia FAB M4-Eo. Cancer Genetics Cytogenetics 182 (1) 56-60, 2008.

O’Brien MM, Taub JW, Chang M, Massey GV, Stine KC, Raimondi SC, Becton D, Ravindranath Y, Dahl GV. Cardiomyopathy in children with Down syndrome treated for acute myeloid leukemia: A report from the Children’s Oncology Group Study POG 9421. J Clin Oncol 26 (3) 414-420, 2008.

Hartford C, Yang W, Cheng C, Fan Y, Liu W, Trevino L, Pounds S, Neale G, Raimondi SC, Bogni A, Dolan ME, Pui C-H, Relling MV. Genome scan implicates adhesion biological pathway in secondary leukemia. Leukemia 21 (10) 2128-2136, 2007.

Raimondi SC. T-lineage acute lymphoblastic leukemia (T-ALL). Atlas Genet Cytogenet Oncol Haematol May 2007. :http://www.infobiogen.fr/services/chromcancer/Anomalies/T-ALL.
URL [http://AtlasGeneticsOncology.org/Anomalies/TALLID1374.html ]

Heerema NA, Raimondi SC, Anderson JR, Biegel J, Camitta BM, Cooley LD, Gaynon PS, Hirsch B, Magenis RE, McGavran L, Patil S, Pettenati MJ, Pullen J, Rao K, Roulston D, Schneider NR, Shuster JJ, Sanger W, Sutcliffe MJ, van Tuinen P, Watson MS, Carroll AJ. Specific extra chromosomes occur in a modal number dependent pattern in pediatric acute lymphoblastic leukemia. Genes Chromosomes Cancer 46 (7) 684-693, 2007.

Hertzberg L, Betts D, Raimondi SC, Schaefer BW, Notterman DA, Domany E, Izraeli S. Prediction of chromosomal aneuploidy from gene expression data. Genes Chromosomes Cancer (46) 75-86, 2007.

Hasle H, Alonzo TA, Auvrignon A, Behar C, Chang M, Creutzig U, Fischer A, Forestier E, Fynn A, Haas OA, Harbott J, Harrison CJ, Heerema NA, van den Heuvel-Eibrink MM, Kaspers GJL, Locatelli F, Noellke P, Polychronopoulou NS, Ravindranath Y, Razzouk B, Reinhardt D, Savva NN, Stark B, Suciu S, Tsukimoto I, Webb DK, Wojcik D, Woods WG, Zimmermann M, Niemeyer CM, Raimondi SC. Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia: An international retrospective study. Blood 109 (11) 4641-4647, 2007.

Wagner LM, Burger RA, Guichard SM, Raimondi SC, Santana VM, Furman WL, Danks MK. Pilot study to evaluate MYCN expression as a neuroblastoma cell marker to detect minimal residual disease by RT-PCR. J Pediatr Hematol Oncol 28: 635-641, 2006.

Savasan S, Buck S, Weinstein H, Raimondi SC, Ravindranath Y. CD36 (thrombospondin receptor) expression in childhood acute megakaryoblastic leukemia: in vitro drug sensitivity and outcome. Leuk Lymphoma 47 (10) 2076-2083, 2006.

Onciu M, Schlette E, Zhou Y, Raimondi SC, Giles FJ, Kantarjian HM, Medeiros LJ, Ribeiro RC, Pui C-H, Sandlund JT. Secondary chromosomal abnormalities predict outcome in pediatric and adult high-stage Burkitt lymphoma. Cancer 107 (5) 1084-1092, 2006.

Raimondi SC, Zhou Y, Shurtleff S, Rubnitz JE, Pui C-H, Behm FG. Near-triploidy (68 to 80 chromosomes) and near tetraploidy (>80 chromosomes) in childhood acute lymphoblastic leukemia: Association with B-lineage blast cells with the ETV6-CBFA2 (TEL-AML1) fusion, with the T-cell immunophenotype, and with a favorable outcome. Cancer Genetics Cytogenetics 169:50-57, 2006.

Sandlund JT, Kastan MB, Kennedy W, Behm FG, Entrekin RE, Pui C-H, Kalwinsky DT, Raimondi SC. A subtle t(3;8) translocation results in juxtaposition of CMYC and BCL6 in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia. Cancer Genetics Cytogenetics 168:69-72, 2006.

Slovak ML, Gundacker H, Bloomfield CD, Dewald G, Appelbaum FR, Larson RA, Tallman MS, Bennett JM, Stirewalt DL, Meshinchi S, Willman CL, Ravindranath Y, Alonzo TA, Carroll AJ, Raimondi SC, Heerema NA. A t(6;9) retrospective study of 69 patients with t(6;9)(p23;q34) AML emphasizes the need for a prospective, multicenter initiative for rare "poor prognosis" myeloid malignancies. Leukemia20:1295-1297, 2006.

DiMartino JF, Norman J Lacayo NJ, Varadi M, Li L, Saraiya C, Ravindranath Y, Yu R, Sikic B, Raimondi SC, Dahl GV. Low or absent SPARC expression in acute myeloid leukemia with MLL rearrangements is associated with sensitivity to growth inhibition by exogenous SPARC protein. Leukemia 20:426-432, 2006.

Becton D, Dahl GV, Ravindranath Y, Chang MN, Behm FG, Raimondi SC, Head DR, Stine KC, Lacayo NJ, Sikic BI, Arceci RJ, Weinstein H. Randomized use of Cyclosporin A (CSA) to modulate P-glycoprotein in children with AML in remission: Pediatric Oncology Study 9421. Blood 107, 1315-1324, 2006.

Woodard P, Barfield R, Hale G, Horwitz E, Leung W, Ribeiro R, Rubnitz J, Srivistava DK, Tong X, Yusuf U, Raimondi S, Pui C-H, Handgretinger R, Cunningham JM. Outcome of hematopoietic stem cell transplantation for pediatric patients with therapy-related acute myelogenous leukemia or myelodysplastic syndrome. Pediatric Blood Cancer (e-print Sept 2005) 47:931-5, 2006.

Ravindranath Y, Chang M, Steuber CP, Becton D, Dahl G, Civin C, Camitta B, Carroll A, Raimondi SC, HJ Weinstein, for the Pediatric Oncology Group. Pediatric Oncology Group (POG) studies of Acute Myeloid Leukemia (AML): A review of four consecutive childhood AML trials conducted between 1981 and 2000. Leukemia 19, 2101-2116, 2005.

Cheng Q, Yang WJ, Raimondi SC, Pui C-H, Relling MV, Evans WE. Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes. Nature Genetics 37, 878-882, 2005.

Moorman AV, Raimondi SC, Pui C-H, Baruchel A, Biondi A, Carroll AJ, Forestier E, Gaynon PS, Harbott J, Harms DO, Heerema N, Pieters R, Schrappe M, Silverman LB, Vilmer E, Harrison CJ, on behaf of the Ponte di Legno working group. No prognostic effect of additional chromosomal abnormalities in children with acute lymphoblastic leukemia and 11q23 abnormalities. Leukemia 19, 557-563, 2005.

Hijiya N, Gajjar A, Zhang Z, Sandlund JT, Ribeiro RC, Rubnitz JE, Jeha S, Lui W, Cheng C, Raimondi SC, Behm FG, Rivera GK, Relling MV, Pui C-H. Low-dose oral etoposide-based induction regimen for children with acute lymphoblastic leukemia in first bone marrow relapse. Leukemia 18, 1581-1586, 2004.

Ross ME, Mahfouz R, Onciu M, Liu H-C, Zhou X, Song G, Shurtleff SA, Pounds S, Cheng C, Ma J, Ribeiro RC, Rubnitz JE, Girtman K, Williams WK, Raimondi SC, Liang D-C, Shih L-Y, Pui C-H, Downing JR. Gene expression profiling of pediatric acute myelogenous leukemia. Blood 104:3679-3687, 2004.

Pui C-H, Sandlund TJ, Pei D, Campana D, Rivera GK, Ribeiro RC, Rubnitz JE, Razzouk BI, Howard SC, Hudson MM, Cheng C, Kun LE, Raimondi SC, Behm FG, Downing JR, Relling MV, Evans WE. Improved outcome for children with acute lymphoblastic leukemia: results of Total Therapy Study XIIIB at St Jude Children’s Research Hospital. Blood 104:2690-2696, 2004.

Hijiya N, Gajjar A, Zhang Z, Sandlund JT, Ribeiro RC, Rubnitz JE, Jeha S, Liu W, Cheng C, Raimondi SC, Behm FG, Rivera GK, Relling MV, Pui C-H. Low-dose oral etoposide–based induction regimen for children with acute lymphoblastic leukemia in first bone marrow relapse. Leukemia 18:1581-1586, 2004.

Heerema NA, Harbott J, Galimberti S, Camitta BM, Gaynon PS, Janka-Schaub G, Kamps W, Basso G, Pui C-H, Schrappe M, Auclerc M-F, Carroll AJ, Conter V, Harrison CJ, Pullen J, Raimondi SC, Richards S, Riehm H, Sather HN, Shuster JJ, Silverman LB, Valsecchi MG, Aricò M. Secondary cytogenetic aberrations in childhood Philadelphia chromosome positive acute lymphoblastic leukemia are non-random and may be associated with outcome. Leukemia 18:693-702, 2004.

Raimondi SC. 11q23 rearrangements in childhood acute lymphoblastic leukemia. Atlas Genet Cytogenet Oncol Haematol February 2004. http://www.infobiogen.fr/services/chromcancer/Anomalies/11q23ChildALLID1321.html

Last update: June 2009

 

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