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Finding Cures. Saving Children.
Stephen White, DPhil
Member, St. Jude Faculty
Chair, Structural Biology
Adjunct Full Professor, University of Tennessee Health Science Center
Departments
Structural Biology
Contact Information
Stephen White, DPhil
Structural Biology
Room D1024E
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: stephen.white@stjude.org
Phone: (901) 595-3040
FAX: (901) 595-3032
Education
BS - University of Bristol, United Kingdom (1974)
DPhil - University of Oxford, United Kingdom (1978)
Research Interests
- Structure and function of biological macromolecules
- X-ray crystallography
- Enzyme mechanisms and drug design
- Fatty acid synthesis
- DNA repair and recombination in phage T4 and yeast
- Antibiotics
Bacterial Fatty Acid Synthesis
Structural Studies of the Prokaryotic Ribosome
Selected Publications
White SW, Zheng J, Zhang Y-M, Rock CO. The structural biology of type II fatty acid biosynthesis. Ann Rev Biochem (in press), 2005.
Babaoglu K, Qi J, Lee RE, White SW. Crystal structure of 7,8-dihydropteroate synthase from Bacillus anthracis: Mechanism and novel inhibitor design. Structure 12:1705-1717, 2004.
Price AC, Zhang Y-M, Rock CO, White SW. Cofactor-induced conformational rearrangements establish a catalytically competent active site and a proton relay conduit in FabG. Structure 12:417-428, 2004.
Sickmier EA, Kreuzer KN, White SW. The crystal structure of the UvsW helicase from bacteriophage T4. Structure 12:583-592, 2004.
Price AC, Zhang Y-M, White SW. The 1.3Å resolution crystal structure of ß-ketoacyl-acyl carrier protein synthase II from Streptococcus pneumoniae. J Bacteriol 185:4136-4143, 2003.
Zhang Y-M, Marrakchi H, White SW, Rock CO. The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase. J Lipid Res 44:1-10, 2003.
Li N, Sickmier EA, Zhang R, Joachimiak A, White SW. The MotA transcription factor from bacteriophage T4 contains a novel DNA-binding domain: the ‘double wing’ motif. Molecular Microbiology 43:1079-1088, 2002.
Heath RJ, White SW, Rock CO. Inhibitors of fatty acid synthesis as antimicrobial chemotherapeutics. Appl Microbiol Biotechnol 58:695-703, 2002.
Jackowski, S, Zhang Y-M, Price AC, White SW, Rock CO. A missense mutation in the fabB (ß-ketoacyl-{acyl protein synthase I) gene confers thiolactomycin resistance to Escherichia coli. Antimicrobial Agents and Chemotherapy 46:1246-1252, 2002.
Heath RJ, White SW, Rock CO. Lipid biosynthesis as a target for antimicrobial agents. Prog Lipid Res 40:467-497, 2001.
Price AC, Zhang Y-M, Rock CO, White SW. The structure of ß-ketoacyl-[acyl carrier protein] reductase from Escherichia coli: negative cooperativity and its structural basis. Biochemistry 40:12772-12781, 2001.
D’Costa S, Slobod KS, Webster RG, White SW, Hurwitz JL. Structural features of HIV envelope defined by antibody escape mutant analysis. AIDS Res Human Retroviruses 17:1205-1209, 2001.
Li N, Zhang W, White SW, Kriwacki RW. Solution structure of the transcriptional activation domain of the bacteriophage T4 protein, MotA. Biochemistry 40:4293-4302, 2001.
Xu Y, Heath RJ, Li Z, Rock CO, White SW. The FadR-DNA complex: Transcriptional control of fatty acid metabolism in Escherichia coli. J Biol Chem 276:17373-17379, 2001.
Surman S, Lockey TD, Slobod KS, Jones B, Riberdy JM, White SW, Doherty PC, Hurwitz J. Localization of CD4+ cell epitope hotspots to exposed strands of HIV envelope glycoprotein suggests structural influences on antigen processing. PNAS 98:4587-4592, 2001.
Zhang Y-M, Rao MS, Heath RJ, Price AC, Olson AJ, Rock CO, White SW. Identification and analysis of the acyl carrier protein (ACP) docking site on ketoacyl-ACP synthase III. J Biol Chem 276:8231-8238, 2001.
Price AC, Choi K-H, Heath RJ, Li Z, White SW, Rock CO. Inhibition of ß-ketoacyl-acyl carrier
protein synthases by thiolactomycin and cerulenin. J Biol Chem 276:6551-6559, 2001.
Davies C, White SW, Nicholas RA. Crystal structure of a deacylation-defective mutant of penicillin-binding protein 5 at 2.3Å resolution. J Biol Chem 276:616-623, 2001.
Last update: January 2005
