Rehg: Pathologic expression of genes in genetically engineered mice

Genetically engineered mice, often known as transgenic or knockout mice, are now a standard means of exploring the complex molecular biologic effects of a gene. A pathologic assessment of genetically engineered mice is often crucial for the characterization of a gene’s function at the whole-animal level.

• Phenotype.
• Characterization of genetically engineered mice.
• Molecular biologic effects of genes in transgenic and nontransgenic mice.

Pathogenesis of infectious diseases resulting from bacteria, protozoa, and viruses

Animal models of infectious diseases are often crucial for elucidation of the pathogenetic mechanism of virulence and the effect of vaccines as therapeutic modalities.

• Variables affecting the efficacy of chemotherapy for Cryptosporidium parvum infection.
• Dexamethasone-mediated Cryptosporidium parvum infection in the SCID mouse.
• Contribution of gamma delta T cells to protection against Cryptosporidium parvum in mice that lack alpha beta T cells.

 

Last update: April 2003