Non-Therapeutic Protocol

CARHAB: Resistance and Aerobic Exercise for Subclinical Anthracycline Cardiomyopathy

Type of Protocol/Clinical Study

Supportive Studies: Long Term Effects : Survivors of childhood cancer


This is a pilot study that evaluates the possibility of interventions to decrease the risk of cardiac death in survivors of childhood cancer, the rate of which is known to be significantly increased. This is a 12 week exercise intervention which is designed for childhood cancer survivors who have been treated with anthracyclines (anthracyclines are employed for the treatment of approximately 45% of children with cancer and cause long-term damage to the hearts of many of those who are treated successfully) and known to have cardiomyopathy (cardiomyopathy is a serious disease in which the heart muscle becomes inflamed and doesn't work as well as it should. There may be multiple causes including viral infections).

The exercise intervention will include aerobic training in which patients gradually achieve workloads of 40% to 70% of maximal effort for 20 to 45 minutes 3 to 5 times per week for a period of 8 to 12 weeks and resistance training which recommends 1 set of 12 – 15 repetitions, (a repetition is the performance of a particular exercise, such as a biceps curl, one time) using 8 – 10 exercises 2 – 3 days per week. The participants will receive a log book in which they will record their aerobic and resistance exercise activities. The beneficial effects of aerobic and strength exercises have been well established to improve the cardiac functioning as well as cognitive functioning. The duration of the study will take place for 2 years.



Only current St. Jude patients are eligible for non-therapeutic studies.

Inclusion Criteria:

Exclusion Criteria:

Principal Investigator

Daniel Green, MD

The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.