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Associate Member, St. Jude Faculty
Interim International Outreach Co-Director
Director, Radiation Dosimetry Core
Mathew Krasin, MD
MS 220, Room I-3122
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
BS - Texas A&M University (1991)
MD - University of Texas, Galveston (1995)
Focus in my clinical and academic work has centered on pediatric sarcomas and Hodgkin’s disease. I joined the Radiation Oncology faculty in July 2000 and have developed a research program studying focal radiation therapy as applied to patients with rhabdomyosarcoma, Ewing’s sarcoma, soft-tissue sarcomas and Hodgkin’s disease. My studies seek to maximize local tumor control and survival with radiation therapy, employing the most modern technologies (conformal, IMRT and brachytherapy treatment). While achieving cure is paramount, cure without quality of life is unsatisfactory. Therefore, these studies also systematically integrate treatment approaches to further reduce the side effects of radiation. The RT-SARC and Hodgkin’s clinical trials integrate MRI and PET imaging for targeting to deliver highly focused radiation for treatment. Published outcomes have been excellent, confirming the validity of this approach.
Gawade PL, Ness KK, Sharma S, Li Z, Srivastava DK, Spunt SL, Nottage K, Krasin MJ, Hudson MM, Kaste SC. Association of bone mineral density with incidental renal stone in long-term survivors of childhood acute lymphoblastic leukemia. J Cancer Surviv Sep 2012.
Krull KR, Sabin ND, Reddick WE, Zhu L, Armstrong GT, Green DM, Arevalo AR, Krasin MJ, Srivastava DK, Robinson LL, Hudson MM. Neurocognitive function and CNS integrity in adult survivors of childhood Hodgkin lymphoma. J Clin Oncol Sep 2012.
Denbo JW, Shannon Orr W, Wu Y, Wu J, Billups CA, Navid F, Rao BN, Davidoff AM, Krasin MJ. Timing of surgery and the role of adjuvant radiotherapy in Ewing sarcoma of the chest wall: a single-institution experience. Ann Surg Oncol Jul 2012.
Shannon Orr W, Denbo JW, Billups CA, Wu J, Navid F, Rao BN, Davidoff AM, Krasin MJ. Analysis of prognostic factors in extraosseous Ewing sarcoma family of tumors: review of St. Jude Children’s Research Hospital experience. Ann Surg Oncol Jun 2012.
Metzger M, Weinstein H, Hudson M, Billet A, Larsen E, Friedmann A, Howard S, Donaldson S, Krasin M, Kun L, Marcus K, Yock T, Tarbell N, Billups C, Wu J, Link M. Association between radiotherapy vs no radiotherapy based on early response to vamp chemotherapy and survival among children with favorable risk Hodgkin lymphoma. JAMA Jun;307(24):2609-16, 2012.
Nottage K, McFarlane J, Krasin M, Li C, Srivastava D, Robison LL, Hudson MM. Secondary colorectal carcinoma after childhood cancer. J Clin Oncol Jul;30(20):2552-8, 2012.
Pai Panandiker AS, Sharma S, Naik MH, Wu S, Hua C, Beltran C, Krasin MJ, Merchant TE. Novel assessment of renal motion in children as measured via four-dimensional computed tomography. Int J Radiat Oncol Biol Phys Apr;82(5):1771-6, 2012.
Cheuk DK, Sabin ND, Hossain M, Wozniak A, Naik M, Rodriguez-Galindo C, Krasin MJ, Shulkin BL. PET/CT for staging and follow-up of pediatric nasopharyngeal carcinoma. Eur J Nucl Med Mol Imaging Jul;39(7):1097-106, 2012.
Motosue MS, Zhu L, Srivastava K, Stokes DC, Hudson MM, McPherson V, Srinivasan S, Krasin MJ, Green DM, Spunt SL, Inaba H. Pulmonary function after whole lung irradiation in pediatric patients with solid malignancies. Cancer Mar;118(5):1450-6, 2012. PMC3233655
Krasin MJ, Wiese KW, Spunt SL, Daw N, Navid F, Davidoff A, McGregor L, Hua C, Merchant TE, Kun LE, McCrarey L, Hoth KA, Yan X, Xiong X. Jaw dysfunction related to pterygoid and masseter muscle dosimetry after radiation therapy in children and young adults with head-and-neck sarcomas. Int J Radiat Oncol Biol Phys Jan 1;82(1):355-60, 2012. PMC 3117097
Fernandez-Pineda I, Spunt SL, Parida L, Krasin MJ, Davidoff AM, Rao BN. Vaginal tumors in childhood: the experience of St. Jude Children’s Research Hospital. J Pediatr Surg Nov;46(11):2071-5, 2011.
Huang TT, Hudson MM, Stokes DC, Krasin MJ, Spunt SL, Ness KK. Pulmonary outcomes in survivors of childhood cancer: a systematic review. Chest Mar 17, 2011.
Beltran C, Krasin MJ, Merchant TE. Inter- And intrafractional positional uncertainties of pediatric brain tumor patients. Int J Radiat Oncol Biol Phys Mar 15;79(4):1266-74, 2011.
Beltran C, Pai-Panandiker AS, Krasin MJ. Daily image guided localization for neuroblastoma. J Appl Clin Med Phys Oct 11;11(4):3388, 2010.
Hua C, Zhang Y, Glenn GR, Xie F, Krasin MJ. Developing an integrated multimodality image analysis platform for target definition and therapy response assessment in radiation therapy patients. Comput Meth Prog Bio 2011.
Sandlund JT, Pui CH, Mahmoud H, Zhou Y, Lowe E, Kaste S, Kun LE, Krasin MJ, Onciu M, Behm FG, Ribeiro RC, Razzouk BI, Howard SC, Metzger ML, Hale GA, Rencher R, Darnell K, Hudson MM. Efficacy of high-dose methotrexate, ifosfamide, etoposide and dexamethasone (MIED) salvage therapy for recurrent or refractory childhood malignant lymphoma. Annals of Oncology Feb;22(2):468-71, 2011.
Cheuk D, Billups C, Martin M, Roland CR, Krasin MJ, Rodriguez-Galindo C. Nasopharyngeal carcinoma in children: 43 years of experience at St. Jude Children's Research Hospital. Cancer Jan 1;117(1):197-206, 2011.
Hines-Thomas MR, Howard SC, Hudson MM, Krasin MJ, Kaste SC, Shulkin B, Metzger ML. Utility of bone marrow biopsy at diagnosis in pediatric Hodgkin lymphoma. Haematologica Oct;95(10):1691-6, 2010.
Metzger ML, Hudson MM, Krasin MJ, Wu J, Kaste SC, Kun LE, Sandlund JT, Howard SC. Initial response to salvage therapy determines prognosis in relapsed pediatric Hodgkin lymphoma patients. Cancer Sep 15;116(18):4376-84, 2010.
Robbins JR, Krasin MJ, Watkins A, Santana VM, Furman WL, Davidoff AM, McGregor LM. Radiation therapy as part of local control for metastatic neuroblastoma: the St. Jude Children’s Research Hospital experience. J Pediatr Surg 45(4):678-86, April 2010.
Inaba H, Yang J, Pan J, Stokes D, Krasin MJ, Srinivasan A, Hartford C, Pui C, Leung W. Pulmonary dysfunction in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem cell transplantation. Cancer 116(8):2020-30, April 2010.
Krasin MJ, Davidoff AM, Xiong X, Wu S, Hua C, Navid F, Rodriguez-Galindo C, Rao B, Hoth KA, Neel MD, Merchant TE, Kun LE, Spunt SL. Preliminary results from a prospective study using limited margin radiotherapy in pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft-tissue sarcoma. Int J Rad Onc Biol Phys 76(3):874-8, March 2010.
Pai Panandiker A, McGregor L, Krasin MJ, Wu S, Xiong X, Merchant TE. Loco-regional tumor progression after radiation therapy influences overall survival in pediatric patients with neuroblastoma. Int J Rad Onc Biol Phys 76(4):1161-5, March 2010.
Hua C, Hoth KA, Kun LE, Metzger ML, Spunt SL, Wu S, Xiong X, Krasin MJ. Incidence and correlates of radiation pneumonitis in pediatric patients with partial lung irradiation. Int J Radiat Oncol Biol Phys Sep 1;78(1):143-9, 2010.
Krasin MJ, Friedman D, Constine L, Marks LB. Radiation-related treatment effects across the age spectrum: differences and similarities or what we can learn from each other. Semin Radiat Oncol 20(1):21-9, January 2010.
Last update: February 2013