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Research
Elaine I. Tuomanen, MD
The goal of the Department of Infectious Diseases at St. Jude Children’s Research Hospital is to study devastating diseases of childhood through a comprehensive approach including basic science research, translational trials, and bedside care.
Among the top infectious causes of death worldwide are respiratory diseases and HIV/AIDS. The Department of Infectious Diseases seeks to focus on the pathogenesis of these infections with a breadth of commitment that extends from the research bench to the bedside. Investigations take place at four levels: manipulation of genes is expected to lead to phenotypes in cell culture systems that can be modeled in animal studies. Therapeutic candidates in the form of antimicrobials, vaccines, or adjunctive therapies are further pursued in clinical trials in children.
Investigations of infections in immunocompromised children aim at development of a risk prediction tool using inflammatory markers and molecular diagnostic assays to allow risk-stratified management approaches in febrile neutropenic children with cancer. The immune response of this high-risk population to childhood vaccines is also under study.
Study of respiratory pathogens includes investigations on the molecular pathogenesis of invasion and inflammation induced by the pneumococcus, synergistic interactions between pneumococcus and influenza, and elucidation of the natural history of influenza and parainfluenza viruses, including pandemic influenza. The influenza program leads the US effort against pandemic influenza and collaborates with the World Health Organization in tracking emergence of new influenza strains. The Translational Trials Unit houses the nationally recognized comprehensive, clinical care and research program for HIV infected children and adolescents. Novel vaccine approaches for parainfluenza viruses, respiratory syncytial virus, influenza viruses, and pneumococcus are under development.
Department of Infectious Diseases
St Jude Children's Research Hospital
IRC E8057 Mailstop 320
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: elaine.tuomanen@stjude.org
Phone: 901-595-3114
Fax: 901-595-3099
Preferred contact method: email
Elisabeth E. Adderson, MD Pediatric Infectious Diseases Fellowship Director
Miguela A. Caniza, MD Infectious Diseases International Outreach
P. Joan Chesney, MD Bacterial pathogenesis; graduate medical education; continuing medical education
Patricia M. Flynn, MD Pediatric/Adolescent HIV/AIDS clinical trials
Aditya H. Gaur, MD Pediatric/Adolescent HIV/AIDS clinical trials
Hans Haecker, MD, PhD Toll-like receptor signal transduction
Hana Hakim, MD, MS Risk stratification of febrile neutropenic children with cancer
Julia L. Hurwitz, PhD Paramyxovirus and HIV vaccine design
Suzanne Jackowski, PhD Bacterial lipid metabolism
Gabriela Marón, MD Fungal infections in immunocompromised patients
Timothy Minniear, MD Hospital epidemiology and clinical diagnostics
Peter J. Murray, PhD Downmodulation of inflammation
Charles O. Rock, PhD Bacterial lipid metabolism
Jason W. Rosch, PhD Bacterial genomics and metal transport
Charles J. Russell, PhD Viral replication and vaccine design
Stacey L. Schultz-Cherry, PhD Influenza virus and astrovirus pathogenesis
Elaine I. Tuomanen, MD Pathogenesis of Streptococcus pneumoniae
Richard J. Webby, PhD Influenza pathogenesis and vaccine design
Robert G. Webster, PhD Influenza pathogenesis and vaccine design
Walter T. Hughes, MD Emeritus
Katherine Knapp, MD Pediatric/adolescent HIV/AIDS clinical trials
Nehali Patel, MD Pediatric/adolescent HIV clinical care
Megan Wilkins, PhD Clinical & research psychological services for children/adolescents with HIV/AIDS
