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Finding Cures. Saving Children.
Infectious Diseases
The goal of the Department of Infectious Diseases at St. Jude Children¹s Research Hospital is to study devastating diseases of childhood through a comprehensive approach including basic science research, translational trials, and bedside care.
Among the top infectious causes of death worldwide are respiratory diseases and AIDS. The Department of Infectious Diseases seeks to focus on the pathogenesis of these infections with a breadth of commitment that extends from the research bench to the bedside. Investigations take place at four levels: manipulation of genes is expected to lead to phenotypes in cell culture systems that can be modeled in animal studies. Therapeutic candidates in the form of antibiotics, vaccines, or adjunctive therapies are further pursued in clinical trials in children.
Study of respiratory pathogens includes investigations on the molecular pathogenesis of invasion and inflammation induced by the pneumococcus, synergistic interactions between pneumococcus and influenza, and elucidation of the natural history of influenza and parainfluenza viruses, including pandemic influenza. The influenza program leads the US effort against pandemic influenza and collaborates with the World Health Organization in tracking emergence of new influenza strains. The Translational Trials Unit houses the nationally recognized program developing treatment options for adolescent AIDS. Novel vaccine approaches for parainfluenza viruses, respiratory syncytial virus, influenza viruses, and pneumococcus are under development. The GMP facility facilitates these current investigations by complementing the Translational Trials Unit and the Hartwell Center for Biotechnology.
The Department of Infectious Diseases at St. Jude is chaired by Elaine Tuomanen, MD.
