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Finding Cures. Saving Children.
Jill M. Lahti, PhD
Associate Member, St. Jude Faculty
Director, Cytogenetics Shared Resource
Departments
Genetics / Tumor Cell Biology
Contact Information
Jill Lahti, PhD
Genetics / Tumor Cell Biology
MS350, Room D5006E
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: jill.lahti@stjude.org
Phone: (901) 595-3501
FAX: (901) 595-2381
Education
PhD - Baylor College of Medicine, Houston, TX
Research Interests
My laboratory is focused on understand how aberrations in apoptosis, transcription and cell division contribute to human tumorigenesis and tumor metastasis. The three main areas of investigation are:
- Determining the role of caspase-8 in neuroblastoma tumorigenesis and metastasis
- Defining the different roles and biological significance of the three different CDK11 protein isoforms in transcription, splicing and mitosis
- Understanding the role of the ChlR1 DNA helicase in chromosome cohesion and chromatin structure.
Selected Publications
Barbero S, Mieglo A, Torres V, Teitz T, Shields DJ, Mikolon D, Bogyo M, Barila D, Lahti JM, Schlaepfer D, Stupack DG. Caspase-8 association with focal adhesion complex promotes tumor cell migration and metastasis. Can Res 2009 (in press).
Inoue A, Hyle J, Lechner MS, Lahti JM. Perturbation of HP1 localization and chromatin binding ability causes defects in sister-chromatid cohesion. Mutat Res 657:48-55, 2008.
Jiang M, Zhu K, Grenet J, Lahti JM. Activation of Caspase-8 by retinoic acid sensitizes neuroblastoma cells to TNFα- and drug- induced apoptosis. BBA-Mol Cell Res 1783:1055-1067, 2008.
Loyer P, Trembley JH, Grenet J, Busson A, Corlu A, Kidd VJ, Lahti JM. Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: Influence of cyclin L isoforms on splice site selection. J Biol Chem 283:7721-7732, 2008.
Hu D, Valentine MB, Kidd VJ, Lahti JM. CDK11p58 is required for the maintenance of sister chromatid cohesion. J Cell Sci 120: 2424-2434, 2007.
Inoue A, Li T, Roby SK, Valentine MB, Inoue M, Boyd, K, Kidd VJ, Lahti JM. Loss of ChlR1 Helicase in Mouse Causes Lethality Due to the Accumulation of Aneuploid Cells Generated by Cohesion Defects and Placental Malformation. Cell Cycle 6: 1646-1654, 2007.
Katona RL, Loyer P, Roby SK, Lahti JM. Two isoforms of the human cyclin C gene are expressed differentially suggesting that they may have distinct functions. Acta Biol Hung 58:133-137, 2007.
Katona R, Lahti JM. Cyclin C Molecule pages for the Alliance for Cellular Signaling. Alliance for Cellular Signaling-Nature Molecule Pages doi:10.1038/mp.a000720.01, 2006.
Katona R, Lahti JM. CDK8 Molecule pages for the Alliance for Cellular Signaling. Alliance for Cellular Signaling-Nature Molecule Pages doi:10.1038/mp.a003009.01, 2006.
Trembley JH, Lahti JM. CDK11 Molecule pages for the Alliance for Cellular Signaling. Alliance for Cellular Signaling-Nature Molecule Pages doi:10.1038/mp.a001828.01, 2006.
Parish JL, Rosa J, Wang X, Lahti JM, Doxsey S, Androphy EJ. The DNA helicase hChlR1 is required for sister chromatid cohesion in mammalian cells. J Cell Sci 119: 4857-4864, 2006.
Tekautz T, Zhu K, Grenet J, Kidd VJ, Lahti JM. Evaluation of IFNγ effects on apoptosis and gene expression- preclinical studies. BBA-Molecular and Cellular Research 1763:1000-1010, 2006.
Zhang J, Lahti JM, Bruce A, He L, Parihar K, Fan C, Grenet J, Liu L, Kidd VJ, Cormier S, Tang D. Identification of an ATM-mediated surveillence system to regulate Bcl-2 over-expression. Oncognene 25: 5601-5611, 2006.
Helfer B, Boswell BC, Finlay D, Cipres A, Vuori K, Bong Kang T, Wallach D, Dorfleutner A, Lahti JM, Flynn DC, Frisch SM. Caspase-8 Promotes Cell Motility and Calpain Activity under Nonapoptotic conditions. Cancer Res 66: 4273-4278, 2006.
Teitz T, Stupack DG, Lahti JM. Halting neuroblastoma metastasis by controlling integrin-mediated cell death. Cell Cycle 5:681-685, 2006.
Stupack D, Teitz T, Potter M, Mikolon D, Houghton PJ, Kidd VJ, Lahti JM, Cheresh D. Potentiation of neuroblastoma by loss of caspase 8. Nature 439: 95-99, 2006.
Li T, Inoue A, Lahti JM, Kidd VJ. Failure to proliferate and mitotic arrest of CDK11p110/p58 protein kinase null mutant mice at the blastocyst stage of development. Mol Cell Biol 24:3188-3197, 2004.
Hsu L-C, Liu S, Abedinpour F, Beech RB, Lahti JM, Kidd VJ, Greenspan JA, Yeung C-Y. The murine G+C rich promoter binding protein mGPBP is required for promoter-specific transcription. Mol Cell Biol 23: 8773-8785, 2003.
Ramos B, Lahti JM, Claro E, Jackowski S. Prevalence of necrosis in C2-ceramide induced cytotoxicity in NB16 neuroblastoma cells. Molec Pharm 64: 502-511, 2003
Schwerk C, Prasad J, Degenhardt K, Erdjument-Bromage H, White E, Tempst P, Kidd VJ, Manley JL, Lahti JM, Reinberg D. ASAP, a Novel Protein Complex Involved in RNA Processing and Apoptosis. Mol Cell Biol 23: 2981-2990, 2003.
Hu D, Mayeda A, Trembley JH, Lahti JM, Kidd VJ. CDK11 complexes promote pre-mRNA splicing. J Biol Chem 278: 8623-8629, 2003.
Trembley JH, Hu D, Slaughter CA, Lahti JM, Kidd VJ. Casein Kinase 2 Interacts with Cyclin-dependent Kinase 11 (CDK11) in vivo and Phosphorylates Both the RNA Polymerase II Carboxyl-terminal Domain and CDK11 in vitro. J Biol Chem 278 2265-2270, 2003.
Teitz T, Lahti JM, Kidd VJ. Reply to “Expression and methylation of CASP8 in neuroblastoma: Identification of a promoter region. Nature Medicine 8:1335, 2002.
Wu D, Ingram A, Lahti JM, Mazza B, Grenet J, Kapoor A, Liu L, Kidd VJ, Tang D. Apoptotic Release of Histones from Nucleosomes. J Biol Chem 277 12001-12008, 2002.
Tang D, Wu D, Hirano A, Lahti JM, Liu L, Mazza B, Kidd VJ, Mak TW, Ingram AJ. ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. J Biol Chem 277: 1710-12712, 2002.
Trembley JH, Hu, D, Tang D, Lahti JM, Kidd VJ. PITSLRE p110 protein kinases associate with transcriptional elongation factors and RNA polymerase II in vivo. J Biol Chem 277: 2589-2596, 2002.
Teitz T, Wei T, Liu D, Valentine V, Valentine M, Grenet J, Lahti JM, Kidd VJ. Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN. Oncogene 21: 1848-1858, 2002.
Last update: March 2009
