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Research
| Technology Name (St. Jude Reference #) | Retroviral Gene Transfer System (SJ-00-0004) |
| Description | This invention provides a highly efficient and consistent method for transducing stem cells with exogenous genes using feline endogenous retrovirus (RD114) envelope pseudotyped vectors. The RD114 pseudotyped vectors can be preabsorbed onto a surface, making gene therapy possible without the need for a GMP facility. |
| Keywords | Gene therapy, retroviral gene transfer, stem cells |
| Granted Patents or Published Applications | US Patent No. 6,849,454 |
| Related Scientific References | Kelly, P.F. et. al. “Highly efficient gene transfer into cord blood nonobese diabetic/severe combined immunodeficiency oncoretroviral particles pseudotyped with the feline endogenous retrovirus (RD114) envelope protein” Blood 96: 1206-1214 (2000). Nathwani, A.C. et. al. “Efficient gene transfer into human cord blood CD34+ cells and the CD34+CD38-subset using highly purified recombinant adeno-associated viral vector preparations that are free of helper virus and wild-type AAV” Gene Ther. 7: 183-195 (2000). |
| Licensing Opportunities | We are currently seeking licensing opportunities in all fields for the development of this technology. |
Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.
Last update: June 2006
