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|Technology Name |
(St. Jude Reference #)
|Retroviral Gene Transfer System |
|Description||This invention provides a highly efficient and consistent method for transducing stem cells with exogenous genes using feline endogenous retrovirus (RD114) envelope pseudotyped vectors. The RD114 pseudotyped vectors can be preabsorbed onto a surface, making gene therapy possible without the need for a GMP facility.|
|Keywords||Gene therapy, retroviral gene transfer, stem cells|
|Granted Patents or Published Applications||US Patent No. 6,849,454|
|Related Scientific References||Kelly, P.F. et. al. “Highly efficient gene transfer into cord blood nonobese diabetic/severe combined immunodeficiency oncoretroviral particles pseudotyped with the feline endogenous retrovirus (RD114) envelope protein” Blood 96: 1206-1214 (2000). |
Nathwani, A.C. et. al. “Efficient gene transfer into human cord blood CD34+ cells and the CD34+CD38-subset using highly purified recombinant adeno-associated viral vector preparations that are free of helper virus and wild-type AAV” Gene Ther. 7: 183-195 (2000).
|Licensing Opportunities||We are currently seeking licensing opportunities in all fields for the development of this technology.|
Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.
Last update: June 2006