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Gajjar: 2000-2004 Publications

Fouladi M, Chintagumpala M, Laningham FH, Ashley D, Kellie SJ, Langston JW, McCluggage CW, Woo S, Kocak M, Krull K, Kun LE, Mulhern RM, Gajjar A. White Matter Lesions Detected by Magnetic Resonance Imaging Following Radiotherapy and High Dose Chemotherapy in Children with Medulloblastoma/PNET. J Clin Oncol 22(22): 4551-4560, 2004.

Stewart CF, Iacono LC, Chintagumpala M, Kellie SJ, Ashley D, Zamboni WC, Kirstein MN, Fouladi M, Seele LG, Wallace D, Houghton PJ, Gajjar A. Results of a Phase II Upfront Window of Pharmacokinetically Guided Topotecan in High-Risk Medulloblastoma and Supratentorial Primitive Neuroectodermal Tumor (PNET). J Clin Oncol 22(16): 3357-3365, 2004.

Nagel B, Palmer S, Reddick W, Glass JO, Helton K, Wu S, Xiong X, Kun LE, Gajjar A, Mulhern R. Abnormal Hippocampal Development Among Pediatric Patients with Medulloblastoma Treated With Risk-Adapted Radiation Therapy. Am J Neuroradiol 25:1575-1582, 2004.

Broniscer A, Ke Weiming , Fuller CE, Wu J, Gajjar A, Kun LE. Second neoplasm in pediatric patients with primary central nervous system tumors: The St Jude Children’s Research Hospital Experience. Cancer 100 (10): 2246-52, 2004.

Gajjar A, Hernan R, Kocak M, Fuller C, Lee Y , McKinnon P, Wallace D, Lau C, Chintagumpala M, Ashley D M, Kellie S J, Kun L, Gilbertson, RJ. Clinical, Histopathological and Molecular Markers of Prognosis: Toward a New Disease Risk Stratification System for Medulloblastoma. J Clin Oncol 22 (6): 984-993, 2004.

Smith ES, Gajjar A, Hijiya N, Razzouk BI, Ribeiro RC, Rivera GK, Rubnitz JE, Sandlund JT, Andreansky M, Hancock ML, Pui CH, Campana D. Clinical Significance of minimal residual disease in childhood acute lymphoblastic leukemia after first relapse. Leukemia 18:499-504, 2004.

Daw ND, Santana VM, Iacono LC, Furman WL, Hawkins DR, Houghton PJ, Panetta J C, Gajjar A, Stewart CF. A Phase I and Pharmacokinetic Study of Topotecan Administered Orally Once Daily for Five Days for Two Consecutive Weeks to Pediatric Patients with Refractory Solid Tumors. J Clin Oncol 22 (5): 829-837, 2004.

Deitcher SR, Gajjar A, Kun LE, Heideman, RL. Clinically Evident Venous Thromboembolic Events in Children with Brain Tumors. J Pediatr 145(6):848-50, 2004.

Nobuko H, Gajjar A, Zhang Zhe, Sandlund JT, Ribeiro RC, Rubnitz JE, Jeha S, Cheng C, Riamondi SC, Behm FG, Rivera GK, Relling MV, Pui CH. Low dose oral etoposide-based induction regimen for children with acute lymphoblastic leukemia in first bone marrow relapse. Leukemia 18(10): 1581-86, 2004.

Panetta JC, Kirstein MN, Gajjar A, Nair G, Fouladi M, Heideman RL, Wilkinson M, Stewart CF. Population Pharmacokinetics of Temozolomide and Metabolites in Infants and Children with Primary Central Nervous System Tumors. Cancer Chemo Pharmacol 52(6):435-441, 2003.

Edick MJ, Gajjar A, Mahmoud HH, van de Poll MEC, Harrison PL, Rivera GK, Ribeiro RC, Sandlund JT, Boyett JM, Pui C-H, Relling MVR. Pharmacokinetics and pharmocodynamics of oral etoposide in children with relapsed or refractory acute lymphoblastic leukemia. J Clin Oncol 21(7):1340-1346, 2003.

Howard SC, Kaplan SD, Razzouk BI, Rivera GK, Sandlund JT, Ribeiro RC, Rubnitz JE, Gajjar AJ, Skoch JP, Roy S, Hudson M, Pui CH. Urolithiasis in pediatric patients with acute lymphoblastic leukemia. Leukemia 17:541-546, 2003.

Palmer SL, Gajjar A, Reddick WE, Glass JO, Kun LE, Heideman RL, Wu S, Xiong X, Mulhern RK. A growth curve analysis to predict intellectual outcome among children treated for medulloblastoma. Neuropsychology 17(4):548-555, 2003.

Reddick WE, White HA, Glass JO, Wheeler GC, Thompson SJ, Gajjar A, Leigh L, Mulhern R. A developmental model relating normal-appearing white matter volumes with neurocognitive deficits in childhood cancer survivors. Cancer 97:2512-2519, 2003.

Santana VM, Zamboni WC, Kirstein MN, Tan M, Liu T, Gajjar A, Houghton PJ, Stewart CF. Pharmacokinetically guided dose adjustment reduces interpatient variability in topotecan systemic exposure in children with solid tumor. Clin Cancer Res 9:633-640, 2003.

Fouladi M, Jones D, Langston JW, Mulhern R, Gajjar A, Sanford RA, Merchant TE, Jenkins JJ, Berger P, Kun LE, Heideman RL. Survival and functional outcome of children with hypothalamic/chiasmatic tumors. Cancer 97:1084-1092, 2003.

Gajjar A, Chintagumpala MM, Bowers DC, Jones-Wallace D, Stewart CFS, Crews KR. Effect of intrapatient dosage escalation of irinotecan on its pharmacokinetics in pediatric patients who have high-grade gliomas and receive enzyme-inducing anticonvulsant therapy. Cancer 97(9):2374-2380, 2003.

Panetta JC, Kirstein M, Gajjar A, Nair G, Fouladi M, Stewart C. A Mechanistic Mathematical Model of Temozolomide Myelosuppression in Children with High-Grade Gliomas. Math Biosci 186:29-41, 2003.

Gilbertson RJ, Hill A, Hernan R, Kocak M, Geyer R, Olson J, Gajjar A, Rush L, Hamilton RL and Ian F. Pollack on behalf of the Pediatric Brain Tumor Consortium. ERBB1 is Amplified and Overexpressed in High-Grade Diffusely Infiltrative Pediatric Brain Stem Glioma. Clin Cancer Res 9:3620-3624, 2003.

Fouladi M, Helton K, Dalton J, Gilger E, Gajjar A, Merchant T, Kun L, Newsham I, Burger P, Fuller C. Clear Cell Ependymoma: A Clinicopathologic and Radiographic Analysis of 10 Cases. Cancer 98(10):2232-2244, 2003.

Howard SC, Gajjar AJ, Cheng C, Kritchevsky SB, Somes GW, Harrison PL, Ribeiro RC, Rivera GK, Rubnitz JE, Sandlund JT, de Armendi AJ, Razzouk BI, Pui CH. Traumatic lumbar puncture in pediatric patients with acute lymphoblastic leukemia. JAMA 288:2001-2007, 2002.

Palmer SL, Reddick WE, Glass JO, Goloubeva O, Gajjar A, Mulhern RK. Decline in Corpus Callosum Volume among pediatric patients with medulloblastoma: Longitudinal MR Imaging study. Am J Neuroradiol 23:1088-1094, 2002.

Sandlund JT, Harrison P, Rivera GK, Behm FG, Head D, Boyett J, Rubnitz JE, Gajjar A, Raimondi S, Ribeiro R, Hudson M, Relling M, Evans W, Pui C-H. Persistence of lymphoblasts in bone marrow on Day 15 and Day 22-25 of remission induction predicts a dismal treatment outcome in children with acute lymphoblastic leukemia. Blood 100:43-47, 2002.

Helton KJ, Gajjar A, Hill AD, Boop FA, Langston JW. Metastatic disease in the suprasellar region: a site often over looked in the stating of medulloblastoma. Pediatric Neurosurgery 37:111-117, 2002.

Crews KR, Stewart CF, Jones-Wallace D, Thompson SJ, Houghton PJ, Heideman RL, Fouladi MF, Bowers DC, Chintagumpala MM, Gajjar AJ. Altered Irinotecan pharmacokinetics in pediatric high-grade glioma patients receiving enzyme-inducing anticonvulsant therapy. Clin Cancer Res 8:2202-2209, 2002.

Uma HA, Stewart C, Kuttesch JF, Moghrabi A, Meyer W, Pratt C, Gajjar A, Heideman RL. Phase I study of combination therapy with topotecan and carboplatin in pediatric solid tumors. J Clin Oncol 20(1):88-95, 2002.

Yeoh AE, Cunningham J, Yee GC, Houston JA, Richardson SL, Stewart CF, Houghton P, Bowman L, Gajjar A. Topotecan-Filgrastim Combination is an Effective Regimen for Mobilizing Peripheral Blood Stem Cells. Bone Marrow Transplant 28:563-571, 2001.

Strother D, Ashley D, Kellie SJ, Patel A, Jones- Wallace D, Thompson S, Heideman R, Benaim E, Krance R, Bowman L, Gajjar A. Feasibility of Four Consecutive High-Dose Chemotherapy Cycles with Stem-Cell Rescue for Patients with Newly Diagnosed Medulloblastoma or Supratentorial Primitive Neuroectodermal Tumor After Craniospinal Radiotherapy: Results of a Collaborative Study. J Clin Oncol 19(10):2696-2704, 2001.

Fouladi M, Jenkins J, Burger P, Langston J, Merchant T, Heideman R, Thompson S, Sanford A, Kun L, Gajjar A. Pleomorphic Xanthoastrocytoma: Favorable Outcome after Complete Surgical Resection. Neuro-Oncology 3:184-192, 2001.

Palmer SL, Glass JO, Reddick WE, Goloubeva O, Gajjar A, Kun L, Merchant TE, Mulhern RK. Patterns of Intellectual Development among Survivors of Pediatric Medulloblastoma: A Longitudinal Analysis. J Clin Oncol 19(8):2302-2308, 2001.

Thompson SJ, Leigh L, Christensen R, Xiong X, Kun LE, Heideman RL, Reddick E, Gajjar A, Merchant T, Pui C-H, Hudson MM, Mulhern RK. Immediate Neurocognitive Effects of Methylphenidate on Learning-impaired Survivors of Childhood Cancer. J Clin Oncol 19(2):1802-1808, 2001.

Mulhern RK, Palmer SL, Reddick WE, Glass JO, Kun LE, Taylor J, Langston J, Gajjar A. Risks of Young Age for Selected Neurocognitive Deficits in Medulloblastoma are Associated with White Matter Loss. J Clin Oncol 19(2):472-479, 2001.

Pui C-H, Boyett JM, Rivera GK, Hancock ML, Sandlund JT, Ribeiro RC, Rubnitz JE, Behm FG, Raimondi SC, Gajjar A, Razzouk B, Campana D, Kun LE, Relling MV, Evans WE. Long-Term Results of Total Therapy Studies 11, 12, 13A for Childhood Acute Lymphoblastic Leukemia at St. Jude Children’s Research Hospital. Leukemia 14:2286-2294, 2000.

Gajjar A, Mulhern RK, Heideman RL, Sanford RA, Douglass EC, Kovnar EH, Langston JA, Jenkins JJ, Kun LE. Medulloblastoma in very Young Children: Outcome of Definitive Craniospinal Irradiation Following Incomplete Response to Chemotherapy. Classic Papers and Current Comments 5(2):314-319, 2000.

Howard SC, Gajjar A, Ribeiro RC, Rivera GK, Rubnitz JE, Sandlund JT, Harrison PL, Dahl GV, Pui CH. Safety of Lumbar Puncture for Children with Acute Lymphoblastic Leukemia and Thrombocytopenia. JAMA 284:2222-2224, 2000.

Gajjar A, Harrison PL, Sandlund JT, Rivera GK, Ribeiro RC, Rubnitz JE, Razzouk BI, Relling MV, Evans WE, Boyett JM, Pui C-H. Traumatic Lumbar Puncture at Diagnosis Adversely Affects Outcome in Childhood Acute Lymphoblastic Leukemia. Blood 96(10): 3381-3384, 2000.

Reddick WE, Russell JM, Glass JO, Xiong X, Mulhern RK, Langston JW, Merchant TE, Kun LE, Gajjar A. Subtle White Matter Volume Differences in Children Treated for Medulloblastoma with Conventional or Reduced-Dose Craniospinal Irradiation. Magn Reson Imaging 18:787-793, 2000.

Walter AW, Gajjar A, Reardon DA, Thompson SJ, Langston JW, Jones-Wallace D, Kun LE, Heideman RL. Tamoxifen and Carboplatin for Children with Low-Grade Gliomas: A Pilot Study at St. Jude Children’s Research Hospital. J Pediatr Hematol Oncol 22(3):247-251, 2000.

Fouladi M, Langston J, Mulhern R, Xiong X, Jones D, Yang J, Thompson S, Walter A, Heideman R, Kun LE, Gajjar A. Silent Lacunar Lesions Detected by Magnetic Resonance Imaging of Children with Brain Tumors: A Late Sequelae of Therapy. J Clin Oncol 18(4):824-831, 2000.

Wall A, Gajjar A, Link A, Mahmoud H, Pui C-H, Relling MV. Individualized Methotrexate Dosing in Children with Relapsed Acute Lymphoblastic Leukemia. Leukemia 14:221-225, 2000.