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Tumor Cell Biology

Department of Tumor Cell Biology


Charles J. Sherr, MD, PhD

Departmental Focus

Members of this department attempt to understand how oncogenes, tumor suppressors and checkpoint monitors of cellular stress govern tumor initiation, progression, and responses to cancer therapy. Identifying key regulatory proteins, defining their mechanisms of action, and determining how they function within complex signaling networks continues to provide a better understanding of the fundamental processes controlling cell proliferation, apoptosis, cell migration, and metastasis. Emphasis is placed on mouse models of particular pediatric cancers, including medulloblastoma, neuroblastoma, and acute lymphoblastic leukemia. All faculty members participate in interdepartmental Program Project Grants and basic science programs of the St. Jude Children’s Research Hospital Comprehensive Cancer Center.

Contact Us

Tumor Cell Biology
MS 350, Room D5006
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678

Telephone:  901-595-3505
Fax  901-595-2381

Preferred contact method: email


Richard A. Ashmun, PhD4  Applications of flow cytometry and cell separation

Linda M. Hendershot, PhD2  ER quality control in development and disease

Chunliang Li, PhD  Genome editing in cancer development

Martine F. Roussel, PhD1  Pediatric brain tumors: molecular pathways, mouse models and pre-clinical trials

Brenda Schulman, PhD1, 3  Cellular regulation by ubiquitin-like proteins

Charles J. Sherr, MD, PhD  Tumor suppressor–dependent signaling networks

Other appointments:
1 Co-Leader, Cancer Genetics, Biochemistry and Cell Biology Program 
2 Program Director, Solid Tumor Program Project Grant
3 Primary Appointment: Department of Structural Biology
4 Director, Flow Cytometry and Cell Sorting shared resource