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Finding Cures. Saving Children.
2007 News Release Archive
A mechanism in cells that kills germs and destroys cancer drugs and antibiotics is enlisted by a second mechanism that ingests germs from the environment, a finding that could improve treatments for cancer and infections.
Discovery shows how a group of molecules pulls certain types of defective proteins out of the cell’s protein factory, a finding that could help development of new cancer drugs.
The N-Myc gene lives a double life, triggering cancer when it works with the growth-promoting protein IL-3 and causing cell suicide in the absence of IL-3 .
The discovery of a new cytokine called IL-35 could allow clinicians to treat diseases by turning up or down the immune response.
St. Jude Children’s Research Hospital® and Chili’s Grill & Bar® celebrated the national grand opening of the Chili’s Care Center during a dedication ceremony and ribbon cutting today.
Finding that dexamethasone increases fatigue in children suggests that altering timing or dosing of this drug could lessen troublesome effect on sleep and increase quality of life for patients and their families.
Researchers found that certain mutations enable specific cells in the retina to multiply and cause eye cancer, a finding that suggests deliberate genetic manipulations might coax an injured brain to repair itself.
Investigators at St. Jude Children's Research Hospital settled a century-old debate on the origin of the mammalian lymphatic vasculature—the network of vessels and capillaries critical to various essential housekeeping functions in the body. The finding holds the promise for the development of new therapies for lymphatic system disorders, the researchers said.
Children under treatment for cancer are generally emotionally well-adjusted and no more depressed or anxious than other children their age, according to researchers at St. Jude. In studies of depression, anxiety, posttraumatic stress and quality of life, children with cancer do as well as, and often better than their healthy peers.
A study by St. Jude investigators provides strong evidence for why the targeted therapy drug, imatinib (Gleevec™), which has revolutionized the treatment of CML, is often unable prevent relapse of a particularly aggressive form of ALL.
Scientists at St. Jude Children's Research Hospital have found key features that distinguish influenza viruses found in birds from those that infect humans.
A 30-year scientific debate over how specialized cells in the inner ear amplify sound in mammals appears to have been settled more in favor of bouncing cell bodies rather than vibrating, hair-like cilia, according to investigators at St. Jude.
A treatment for neuroblastoma that lands a one-two punch works best when the second punch is timed to take maximum advantage of the first one, according to results of studies at St. Jude.
The annoying bulges of an over-wound telephone cord that shorten its reach and limit a caller's motion help to explain why drugs called camptothecins are so effective in killing cancer cells, according to investigators at St. Jude.
Investigators at St. Jude Children's Research Hospital have discovered how a single molecular "on switch" triggers gene activity that might cause effects ranging from learning and memory capabilities to glucose production in the liver.
Investigators at St. Jude have shown that when the cancer drug irinotecan is given in low doses for multiple days, it eliminates the need to delay treatment to perform genetic testing that determines if the patient is at risk for treatment side effects.
Investigators at St. Jude Children's Research Hospital have used the lowly yeast to gain insights into how a dividing human cell ensures that an identical set of chromosomes gets passed on to each new daughter cell.
Investigators at St. Jude have gained some of the first major insights into how certain genes known to prevent cancer also guide the normal development of the nervous system before birth and during infancy by repairing DNA damage.
Investigators at St. Jude Children's Research Hospital have discovered inherited variations in certain genes that make children with acute lymphoblastic leukemia (ALL) susceptible to the toxic side effects caused by chemotherapy medications.
Investigators at St. Jude Children's Research Hospital had a molecule's eye view of the human cell's DNA repair kit as it assembled on a double-strand break to link together the broken ends.
The antiviral drug peramivir might offer humans significant protection during a pandemic of the avian influenza virus H5N1, according to results of mouse studies conducted by investigators at St. Jude Children's Research Hospital.
Investigators at St. Jude say they have found the best way for predicting when patients will need future surgery to repair hip joints that have deteriorated because of pediatric leukemia or lymphoma treatment.
NIAID designates St. Jude as one of six Centers of Excellence that will study potentially pandemic animal influenza viruses and help the federal government develop strategies for responding to outbreaks.
Investigators at St. Jude Children's Research Hospital have mapped out many of the dynamic genetic and biochemical changes that make up a cellâ¿¿s response to a shortage of a molecule called Coenzyme A (CoA), a key player in metabolism.
Parents might one day give their children a weekly treatment with a nasal spray of virus enzymes to prevent them from getting a severe middle ear infection, based on results of a study done in mice by investigators from St. Jude.
The cancer drug asparaginase fails to help cure some children with acute lymphoblastic leukemia (ALL) because molecules released by certain cells in the bone marrow counteract the effect of that drug, according to investigators at St. Jude.
Results from follow-up study of childhood ALL survivors show the importance of long-term monitoring to identify complications they are at risk for developing later in life and to modify current treatments to reduce those risks, according to St. Jude.
Investigators at St. Jude have discovered previously unsuspected mutations that contribute to the formation of pediatric acute lymphoblastic leukemia, the most common cancer in children.
The yearly influenza vaccine that health officials urge people to get each fall might also offer certain individuals some cross protection against the H5N1 virus, commonly known as bird flu, according to investigators at St. Jude.
The secret to the ability of a molecule critical for cell division to throw off the protein yoke that restrains its activity is the yoke itself -- a disorderly molecule that seems to have a mind of its own, say investigators at St. Jude.
The complex task of launching a well-organized, effective immune system attack on specific targets is thrown into high gear when either of two specific enzymes chop a protein called LAG-3 off the immune cells leading that battle, according to St. Jude.
The freeze-frame image of a molecular relay race, in which one enzyme passes off a protein like a baton to another enzyme, has solved a key mystery to how cells control some vital functions, according to investigators at St. Jude.
Demonstration by St. Jude researchers that special niches made of capillaries protect and stimulate cancer stem cells in the brain explains the origin of these cancers and their reappearance following treatment.
