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Jerold E. Rehg, DVM

Jerold E. Rehg, DVM

Member, St. Jude Faculty
Head, Veterinary Pathology



Contact Information

Jerold Rehg, DVM
MS 250, Room C-5031
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678


BS - University of Missouri Agriculture College (1964)
DVM - University of Missouri School of Veterinary Medicine (1966)

Honors & Awards

Research Interests

Pathologic expression of genes in genetically engineered mice

Selected Publications

Rehg JE, Bush D, Ward JM. The utility of immunohistochemistry for the identification of hematopoietic and lymphoid cells in normal tissues and interpretation of proliferative and inflammatory lesions of mice and rats. Toxicologic Pathology 40:345-374, 2012. ISSN 0192-6233

Kawauchi D, Robinson G, Uziel T, Gibson P, Rehg J, Gao C, Finkelstein D, Qu C, Pounds S, Ellison DW, Gilbertson RJ, Roussel MF. A mouse model of the most aggressive subgroup of human medulloblastoma. Cancer Cell 21(2):168-180, 2012. PMID 22340591

Ulrich DL, Lynch J, Wang Y, Fukuda Y, Nachagair D, Du, G, Sun D, Fan Y, Tsurkan L, Potter PM, Rehg JE, Schuetz J. The ATP-dependent mitochondrial porphyrin importer ABCB6 protects against phenylhydrazine toxicity. J Biol Chem 2012. [Epub ahead of print] PMID 22294697

Ward JM, Rehg JE, Morse HC 3rd. Differentiation of rodent immune and hematopoietic system reactive lesions from neoplasias. Toxicol Pathol 2012. (Epub ahead of print] PMID 2215512

Rehg JE, Ward JM. Morphological and immunohistochemical characterization of sarcomatous tumors in wild-type and genetically engineered mice. Vet Pathol 49(1):206-271, 2012. (Epub 2011] PMID 22136848

Hu S, Niu H, Inaba H, Orwick S, Rose C, Panetta JC, Yang S, Pounds S, Fan Y, Calabrese C, Rehg JE, Campana D, Rubnitz JE,Baker SD. Activity of the multikinase inhibitor sorafenib in combination with cytarabine in acute myeloid leukemia. J Natl Cancer Inst 103(11):893-905, 2011. [Epub 2011] PMID 21487100

Teitz T, Stanke JJ, Federico S, Bradley CL, Brennan R, Zhang J, Johnson MD, Sedlacik J, Inoue M, Zhang ZM, Frase S, Rehg JE, Hillenbrand CM, Finkelstein D, Calabrese C, Dyer MA, Lahti JM. Preclinical models for neuroblastoma: establishing a baseline for treatment. PLoS One 6(4):e19133, 2011. PMID 21559450

Govorkova EA, Marathe BM, Prevost A, Rehg JE, Webster RG. Assessment of the efficacy of the neuraminidase inhibitor oseltamivir against 2009 pandemic H1N1 influenza virus in ferrets. Antiviral Red 91(2):81-88, 2011. [Epub 201] PMID 21635924

Marcelin G, Aldridge JR, Duan S, Ghoneim HE, Rehg J, Marjuki H, Boon AC, McCullers JA, Webby RJ. Fatal outcome of pandemic H1N1 2009 influenza virus infection is associated with immunopathology and impaired lung repair, not enhanced viral burden, in pregnant mice. J Virol 85(21):11208-11219, 2011. [Epub 2011] PMID 21865394

Cline TD, Karlesson EA, Freiden P, Seufzer BJ, Rehg JE, Webby RJ, Schultz-Cherry S. Increased pathogenicity of a reassortant 2009 pandemic H1N1 influenza virus containing an H5N1 hemagglutinin. J Virol 85(23):12262-12270, 2011. [Epub 2011] PMID 21917948

Zhou J, Wu R, High AA, Slaughter CA, Finkelstein D, Rehg JE, Redecke V, Hacker H. A20-binding inhibitor of NF-κB (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein β activation and protects from inflammatory disease. Proc Natl AcadSci USA 108(44):E998-1006, 2011. [Epub 2011] PMID 22011580

Pillai MR, Collison LW, Wang V, Finkelstein D, Rehg JE, Boyd K, Szymczak-Workman AL,Doggett T, Griffith TS, Gerfuson TA, Vignali DA. The plasticity of regulatory T cell function. J Immunol 187(10):4987-4997, 2011. [Epub 2011] PMID 222013112

Garrison SP, Phillips DC, Jeffers JR, Chipuk JE, Parsons MJ, Rehg JE, Opferman JT, Green DR, Zambetti GP. Geneticaly defining the mechansin of Puma-and Bim-induced apoptosis. Cell Death Differ 19(4):642-649, 2012. [Epub 2011] PMID 22015606

Westmoreland JJ, Kilic G, Sartain C, Sirma S, Blain J, Rehg J, Harvey N, Sosa-Pineda B. Pancreas-specific deletion of Prox1 affects development and disrupts homeostasis of the exocrine pancreas. Gastroenterology Dec 13 [Epub ahead of print] 2011. PMID 22178591

Li Z, Wang H, Xue L, Shin DM, Roopenian D, Xu W, Qi CF, Sangster MY, Orihuela CJ, Tuomanen E, Rehg JE, Cui X, Zhang Q, Morse HC 3rd, Morris SW. Emu-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-kappaB pathways generating marginal zone (MZ) B-cell expansion as a precursor to splenic MZ lymphoma. Blood 114:4158-4168, 2009. PMID 19696203

Volk EL, Fan L, Schuster K, Rehg JE, Harris LC. The MDM2A splice variant of MDM2 alters transformation in vitro and tumor spectrum in both arf and p53 null models of tumorigenesis. Mol Cancer Res 7:863-369, 2009. Epub 2009. PMID 19491200

Saab R, Rodriguez-Galindo C, Matmati K, Rehg JE, Baumer SH, Khoury JD, Billups C, Neale G, Helton KJ, Skapek SX. P18inK4c and p53 Act as tumor suppressors in cyclin D1-driven primitive neuroectodermal tumor. Cancer Res 69:440-8, 2009. PIMD:19147556

Ayrault O, Zindy F, Rehg J, Sherr CJ, Roussel MF. Two tumor suppressors, p27Kip1 and patched-1, collaborate to prevent medulloblastoma. Mol Cancer Res 7:33-40, 2009. PMID 19147535

Yen HL, Aldridge JR, Boon AC, Ilyushina NA, Salomon R, Hulse-Post DJ, Marjuki H, Franks J, Boltz DA, Bush D, Lipatov AS, Webby RJ, Rehg JE, Webster RG. Changes in H5N1 influenza virus hemagglutinin receptor binding domain affects systemic spread. Proc Natl Acad Sci USA 106:286-91, 2009. Epub 2008. PMID 19116267

Rehg JE, Sunberg JP. Utility of anti-Pax5 in the diagnosis of lymphoproliferative disorders and neoplasia in mice. Comp Med 58:246-52, 2008. PMID 18589866

Garrison SP, Jeffers JR, Yang C, Nilsson JA, Hall MA, Rehg JE, Yue W, Yu J, Zhang L, Onciu M, Sample JT, Cleveland JL, Zambetti GP. Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis. Mol Cell Biol 28:5391-402, 2008. PMID 18573879

Carew JS, Nawrocki ST, Reddy VK, Bush D, Rehg JE, Goodwin A, Houghton JA, Casero RA Jr, Marton LJ, Cleveland JL. The novel polyamine analogue CGC-11093 enhances the antimyeloma activity of bortezomib. Cancer Res 68:4783-90, 2008. PMID 18559525

Boltz DA, Rehg JE, McClaren J, Webster RG, Govorkova EA. Oseltamivir prophylactic regimens prevent H5N1 influenza morbidity and mortality in a ferret model. J Infect Dis 197:1315-1353, 2008. PMID 18422444

Last update: February 2013