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Brain Tumor : Previously treated brain tumors
This is a randomized phase II study for children previously treated for a primary brain tumor with surgery, chemotherapy, and/or radiation therapy but is now off treatment.
Some children who are treated for a brain tumor have difficulty with attention, memory or the speed at which information is processed by the brain. This can be due to the brain tumor or the treatment for the brain tumor. This study will test whether the drug Modafinil can improve changes in attention, memory, or other thought processes (also referred to as neurocognitive changes) in children who were previously treated for brain cancer.
Participants and their parents/caregivers will complete a series of tests and questionnaires to evaluate the child for neurocognitive deficits in attention, working memory or processing speed. If results show that the participant has a neurocognitive deficit, they can be randomly assigned to receive either Modafinal (a stimulant drug) or placebo (identical looking pill which contains no medicine) twice a day for 6 weeks. Participants will be evaluated weekly by phone or in the clinic for side effects, and will complete a daily medicine log. After 6 weeks, participants and parents will repeat the tests to determine if there was improvement in neurocognitive function.
For the current eligibility status of this clinical study, patient’s family, relatives and/or referring physicians may contact St. Jude Children’s Research Hospital at (901) 595-4599 or (901) 595-2544.
Amar Gajjar, MD
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105 USA
Phone: (901) 595-2544 or (901) 595-4599
FAX: (901) 595-5353
Tabatha E. Doyle, RN
Coordinator, Brain Tumor Program
Phone: (901) 595-2544
Referring or consulting physicians only: firstname.lastname@example.org
For all other inquiries about St. Jude Children's Research Hospital studies: email@example.com
The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.